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Sunitinib represses regulatory T cells to overcome immunotolerance in a murine model of hepatocellular cancer.
Liu D, Li G, Avella DM, Kimchi ET, Kaifi JT, Rubinstein MP, Camp ER, Rockey DC, Schell TD, Staveley-O'Carroll KF. Liu D, et al. Among authors: schell td. Oncoimmunology. 2017 Sep 21;7(1):e1372079. doi: 10.1080/2162402X.2017.1372079. eCollection 2017. Oncoimmunology. 2017. PMID: 29296523 Free PMC article.
Importantly, the additional integration of exogenous naive TAS CD8(+) T cells by adoptive cell transfer (ACT) leads to the elimination of the established tumors without recurrence and promotes long-term survival of the treated mice. Mechanistically, sunitinib treatment pri …
Importantly, the additional integration of exogenous naive TAS CD8(+) T cells by adoptive cell transfer (ACT) leads to the elimination of th …
Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors.
Cozza EM, Cooper TK, Budgeon LR, Christensen ND, Schell TD. Cozza EM, et al. Among authors: schell td. Cancer Immunol Immunother. 2015 Mar;64(3):325-36. doi: 10.1007/s00262-014-1635-7. Epub 2014 Nov 19. Cancer Immunol Immunother. 2015. PMID: 25408469 Free PMC article.
Our group previously demonstrated that ACT following whole-body irradiation (WBI) promotes high-level T cell accumulation, regression of established brain tumors, and long-term protection from tumor recurrence in a mouse model of SV40 T antigen-induced choroid plexus tumor …
Our group previously demonstrated that ACT following whole-body irradiation (WBI) promotes high-level T cell accumulation, regression of est …
Whole-body irradiation increases the magnitude and persistence of adoptively transferred T cells associated with tumor regression in a mouse model of prostate cancer.
Ward-Kavanagh LK, Zhu J, Cooper TK, Schell TD. Ward-Kavanagh LK, et al. Among authors: schell td. Cancer Immunol Res. 2014 Aug;2(8):777-88. doi: 10.1158/2326-6066.CIR-13-0164. Epub 2014 May 6. Cancer Immunol Res. 2014. PMID: 24801834 Free PMC article.
Addition of a second round of immunotherapy promoted regression of established disease in half of the treated mice, with no progression observed. Regression was associated with long-term persistence of effector/memory phenotype CD8(+) donor cells. ...
Addition of a second round of immunotherapy promoted regression of established disease in half of the treated mice, with no progression obse …
Randomized controlled trial of oral glutathione supplementation on body stores of glutathione.
Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE. Richie JP Jr, et al. Among authors: schell td. Eur J Nutr. 2015 Mar;54(2):251-63. doi: 10.1007/s00394-014-0706-z. Epub 2014 May 5. Eur J Nutr. 2015. PMID: 24791752 Clinical Trial.
While oral GSH has been shown to be bioavailable in laboratory animal models, its efficacy in humans has not been established. Our objective was to determine the long-term effectiveness of oral GSH supplementation on body stores of GSH in healthy adults. ...
While oral GSH has been shown to be bioavailable in laboratory animal models, its efficacy in humans has not been established. Our objective …
Combined anti-CD40 conditioning and well-timed immunization prolongs CD8+ T cell accumulation and control of established brain tumors.
Ryan CM, Staveley-O'Carroll K, Schell TD. Ryan CM, et al. Among authors: schell td. J Immunother. 2008 Nov-Dec;31(9):906-20. doi: 10.1097/CJI.0b013e318189f155. J Immunother. 2008. PMID: 18832997 Free PMC article.
Both approaches led to an increase in the lifespan of SV11 mice due to decreased tumor progression. However, tumor-specific T-CD8 did not persist long term at the tumor site after administration of either regimen. Importantly, the combination of anti-CD40 conditioning foll …
Both approaches led to an increase in the lifespan of SV11 mice due to decreased tumor progression. However, tumor-specific T-CD8 did not pe …
CD8+ T cells targeting a single immunodominant epitope are sufficient for elimination of established SV40 T antigen-induced brain tumors.
Tatum AM, Mylin LM, Bender SJ, Fischer MA, Vigliotti BA, Tevethia MJ, Tevethia SS, Schell TD. Tatum AM, et al. Among authors: schell td. J Immunol. 2008 Sep 15;181(6):4406-17. doi: 10.4049/jimmunol.181.6.4406. J Immunol. 2008. PMID: 18768900 Free PMC article.
Additionally, persistence of functional TCR-IV cells in both the brain and peripheral lymphoid organs was associated with long-term tumor-free survival. Finally, we show that production of IFN-gamma, but not perforin or TNF-alpha, by the donor lymphocytes is critical for c …
Additionally, persistence of functional TCR-IV cells in both the brain and peripheral lymphoid organs was associated with long-term t …
Early immunization induces persistent tumor-infiltrating CD8+ T cells against an immunodominant epitope and promotes lifelong control of pancreatic tumor progression in SV40 tumor antigen transgenic mice.
Otahal P, Schell TD, Hutchinson SC, Knowles BB, Tevethia SS. Otahal P, et al. Among authors: schell td. J Immunol. 2006 Sep 1;177(5):3089-99. doi: 10.4049/jimmunol.177.5.3089. J Immunol. 2006. PMID: 16920946
Using rat insulin promoter (RIP) 1-Tag4 transgenic mice that express T Ag from the RIP and develop pancreatic insulinomas, we demonstrate that epitope IV- but not epitope I-specific T(CD8) are maintained long term in tumor-bearing RIP1-Tag4 mice. Even large numbers of TCR- …
Using rat insulin promoter (RIP) 1-Tag4 transgenic mice that express T Ag from the RIP and develop pancreatic insulinomas, we demonstrate th …
Propanil exposure induces delayed but sustained abrogation of cell-mediated immunity through direct interference with cytotoxic T-lymphocyte effectors.
Sheil JM, Frankenberry MA, Schell TD, Brundage KM, Barnett JB. Sheil JM, et al. Among authors: schell td. Environ Health Perspect. 2006 Jul;114(7):1059-64. doi: 10.1289/ehp.8774. Environ Health Perspect. 2006. PMID: 16835059 Free PMC article.
Surprisingly, secondary stimulation of these alloreactive CTL effectors, however, even in the absence of further PRN exposure, resulted in complete abrogation of CTL lytic function and a delayed but significant long-term effect on CTL responsiveness. These findings may hav …
Surprisingly, secondary stimulation of these alloreactive CTL effectors, however, even in the absence of further PRN exposure, resulted in c …