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Assessing the effects of oxytocin in changes of core body temperature during LPS-induced endotoxemia: A novel approach using Extended Poincaré Plot Analysis.
López-Troncoso ÓJ, Reyes-Lagos JJ, Hadamitzky M, Peña-Castillo MÁ, Echeverría JC, Lückemann L, Schedlowski M, Pacheco-López G. López-Troncoso ÓJ, et al. Among authors: schedlowski m. J Therm Biol. 2024 Jan;119:103756. doi: 10.1016/j.jtherbio.2023.103756. Epub 2023 Nov 30. J Therm Biol. 2024. PMID: 38056359
Likewise, the co-administration of oxytocin during endotoxemia (LPS + O) significantly reduced the autocorrelation and increased the short-term variability (SD1) of temperature fluctuations compared to those recorded with a single dose of LPS. ...
Likewise, the co-administration of oxytocin during endotoxemia (LPS + O) significantly reduced the autocorrelation and increased the short- …
Targeting the Meningeal Compartment to Resolve Chemobrain and Neuropathy via Nasal Delivery of Functionalized Mitochondria.
Alexander JF, Mahalingam R, Seua AV, Wu S, Arroyo LD, Hörbelt T, Schedlowski M, Blanco E, Kavelaars A, Heijnen CJ. Alexander JF, et al. Among authors: schedlowski m. Adv Healthc Mater. 2022 Apr;11(8):e2102153. doi: 10.1002/adhm.202102153. Epub 2022 Jan 27. Adv Healthc Mater. 2022. PMID: 35007407 Free PMC article.
Cognitive deficits (chemobrain) and peripheral neuropathy occur in 75% of patients treated for cancer with chemotherapy and persist long-term in >30% of survivors. Without preventive or curative interventions and with increasing survivorship rates, the population debili …
Cognitive deficits (chemobrain) and peripheral neuropathy occur in 75% of patients treated for cancer with chemotherapy and persist long- …
IL-8 and CRP moderate the effects of preoperative psychological interventions on postoperative long-term outcomes 6 months after CABG surgery - The randomized controlled PSY-HEART trial.
Salzmann S, Euteneuer F, Laferton JAC, Shedden-Mora MC, Schedlowski M, Moosdorf R, Rief W. Salzmann S, et al. Among authors: schedlowski m. Brain Behav Immun. 2021 Jan;91:202-211. doi: 10.1016/j.bbi.2020.09.028. Epub 2020 Sep 28. Brain Behav Immun. 2021. PMID: 33002633 Clinical Trial.
CONCLUSION: Especially for patients with a lower inflammatory baseline status preoperative psychological interventions might be helpful to optimize long-term CABG surgery outcomes....
CONCLUSION: Especially for patients with a lower inflammatory baseline status preoperative psychological interventions might be helpful to o …
Psychosocial emergency care in times of COVID-19: the Essen University Hospital concept for corona-infected patients, their relatives, and medical staff.
Rentrop V, Schneider JS, Bäuerle A, Junne F, Dörrie N, Skoda EM, Schedlowski M, Mallmann B, Benecke AV, Kohler H, Gerigk M, Teigelack P, Emler T, Scherbaum N, Gradl-Dietsch G, Scheer K, Teufel M. Rentrop V, et al. Among authors: schedlowski m. Int Arch Occup Environ Health. 2021 Feb;94(2):347-350. doi: 10.1007/s00420-020-01580-z. Epub 2020 Sep 22. Int Arch Occup Environ Health. 2021. PMID: 32964313 Free PMC article.
The University hospital of Essen has taken up this challenge by creating the PEC concept to reduce psychosocial long-term consequences for infected patients, relatives, and medical staff at the university hospital. ...
The University hospital of Essen has taken up this challenge by creating the PEC concept to reduce psychosocial long-term consequence …
Sick for science: experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression.
Lasselin J, Lekander M, Benson S, Schedlowski M, Engler H. Lasselin J, et al. Among authors: schedlowski m. Mol Psychiatry. 2021 Aug;26(8):3672-3683. doi: 10.1038/s41380-020-00869-2. Epub 2020 Sep 1. Mol Psychiatry. 2021. PMID: 32873895 Free PMC article. Review.
Experimental administration of endotoxin in healthy volunteers is safe, well-tolerated, and without known long-term health risks. It offers a highly standardized translational approach to characterize potential targets of therapies against inflammation-associated depressio …
Experimental administration of endotoxin in healthy volunteers is safe, well-tolerated, and without known long-term health risks. It …
Acute Versus Chronic Administration of Calcineurin-Inhibitors Differentially Affect T-Cell Function.
Kirchhof J, Wilde B, Schmidt J, Mülling N, Petrakova L, Brinkhoff A, Schedlowski M, Witzke O. Kirchhof J, et al. Among authors: schedlowski m. Endocr Metab Immune Disord Drug Targets. 2021;21(6):1083-1089. doi: 10.2174/1871530320999200831161710. Endocr Metab Immune Disord Drug Targets. 2021. PMID: 32867664
IFNgamma was not suppressed in patients with long-term CNI treatment. IL-2 production, CD25 expression, and T-cell proliferation were enhanced in long-term CNI patients. CONCLUSION: Suppression of IFNgamma/IL-2 and T-cell proliferation is weaker during long-term …
IFNgamma was not suppressed in patients with long-term CNI treatment. IL-2 production, CD25 expression, and T-cell proliferation were …
Postpartal Affective and Endocrine Differences Between Parents of Preterm and Full-Term Infants.
Weigl T, Schneider N, Stein A, Felderhoff-Müser U, Schedlowski M, Engler H. Weigl T, et al. Among authors: schedlowski m. Front Psychiatry. 2020 Apr 1;11:251. doi: 10.3389/fpsyt.2020.00251. eCollection 2020. Front Psychiatry. 2020. PMID: 32296356 Free PMC article.
In this exploratory, cross-sectional study, we compared psychological well-being and endocrine parameters in parents of very preterm and term born infants. METHODS: Mothers (N = 28) and fathers (N = 30) of full-term infants as well as mothers (N = 18) and fathers (N …
In this exploratory, cross-sectional study, we compared psychological well-being and endocrine parameters in parents of very preterm and …
Symbolic analysis of heart rate fluctuations identifies cardiac autonomic modifications during LPS-induced endotoxemia.
Reyes-Lagos JJ, Ledesma-Ramírez CI, Hadamitzky M, Peña-Castillo MÁ, Echeverría JC, Lückemann L, Schedlowski M, Berg K, Wessel N, Pacheco-López G. Reyes-Lagos JJ, et al. Among authors: schedlowski m. Auton Neurosci. 2019 Nov;221:102577. doi: 10.1016/j.autneu.2019.102577. Epub 2019 Jul 16. Auton Neurosci. 2019. PMID: 31445407
This modification is probably related to a reduced activity of the cholinergic anti-inflammatory pathway at the long term....
This modification is probably related to a reduced activity of the cholinergic anti-inflammatory pathway at the long term....
Effects of Preoperative Psychological Interventions on Catecholamine and Cortisol Levels After Surgery in Coronary Artery Bypass Graft Patients: The Randomized Controlled PSY-HEART Trial.
Salzmann S, Euteneuer F, Laferton JAC, Auer CJ, Shedden-Mora MC, Schedlowski M, Moosdorf R, Rief W. Salzmann S, et al. Among authors: schedlowski m. Psychosom Med. 2017 Sep;79(7):806-814. doi: 10.1097/PSY.0000000000000483. Psychosom Med. 2017. PMID: 28846584 Clinical Trial.
Patients' postoperative stress responses could be an important factor for explaining trajectories of long-term outcomes. CLINICAL TRIAL REGISTRATION: www.clinicaltrials.gov(NCT01407055)....
Patients' postoperative stress responses could be an important factor for explaining trajectories of long-term outcomes. CLINICAL TRI …
Acute administration of cyclosporine A does not impair attention or memory performance in healthy men.
Kahl AL, Kirchhof J, Füting A, Hütter BO, Wilde B, Witzke O, Benson S, Hadamitzky M, Schedlowski M. Kahl AL, et al. Among authors: schedlowski m. Behav Pharmacol. 2017 Jun;28(4):255-261. doi: 10.1097/FBP.0000000000000281. Behav Pharmacol. 2017. PMID: 28079600 Clinical Trial.
The data indicate that short-term CsA-administration and subsequent suppression in interleukin-2 production are accompanied neither by a decrease in attention or memory performance nor by increased anxiety levels in healthy male volunteers, suggesting that the short-ter …
The data indicate that short-term CsA-administration and subsequent suppression in interleukin-2 production are accompanied neither b …
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