Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

27 results

Filters applied: . Clear all
Page 1
Adult Prg4+ progenitors repair long-term articular cartilage wounds in vivo.
Massengale M, Massengale JL, Benson CR, Baryawno N, Oki T, Steinhauser ML, Wang A, Balani D, Oh LS, Randolph MA, Gill TJ 3rd, Kronenberg HM, Scadden DT. Massengale M, et al. Among authors: scadden dt. JCI Insight. 2023 Sep 8;8(17):e167858. doi: 10.1172/jci.insight.167858. JCI Insight. 2023. PMID: 37681409 Free PMC article.
., full-thickness microfracture joint surgery, we combined the mouse full-thickness injury model with lineage tracing and identified a distinct skeletal progenitor cell type enabling long-term (beyond 7 days after injury) articular cartilage repair in vivo. Deriving from a …
., full-thickness microfracture joint surgery, we combined the mouse full-thickness injury model with lineage tracing and identified a disti …
Identification of Functionally Distinct Mx1+αSMA+ Periosteal Skeletal Stem Cells.
Ortinau LC, Wang H, Lei K, Deveza L, Jeong Y, Hara Y, Grafe I, Rosenfeld SB, Lee D, Lee B, Scadden DT, Park D. Ortinau LC, et al. Among authors: scadden dt. Cell Stem Cell. 2019 Dec 5;25(6):784-796.e5. doi: 10.1016/j.stem.2019.11.003. Cell Stem Cell. 2019. PMID: 31809737 Free PMC article.
Here, we report animal models that selectively and durably label postnatal Mx1+alphaSMA+ periosteal stem cells (P-SSCs) and establish that P-SSCs are a long-term repopulating, functionally distinct SSC subset responsible for lifelong generation of periosteal osteoblasts. . …
Here, we report animal models that selectively and durably label postnatal Mx1+alphaSMA+ periosteal stem cells (P-SSCs) and establish that P …
Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping.
Severe N, Karabacak NM, Gustafsson K, Baryawno N, Courties G, Kfoury Y, Kokkaliaris KD, Rhee C, Lee D, Scadden EW, Garcia-Robledo JE, Brouse T, Nahrendorf M, Toner M, Scadden DT. Severe N, et al. Among authors: scadden dt. Cell Stem Cell. 2019 Oct 3;25(4):570-583.e7. doi: 10.1016/j.stem.2019.06.003. Epub 2019 Jul 3. Cell Stem Cell. 2019. PMID: 31279774 Free PMC article.
Genetic ablation of CD73 compromised HSPC transplantation in an acute setting without long-term changes in bone marrow HSPCs. Thus, this protein-based expression mapping reveals distinct sets of stromal cells in the bone marrow and how they change in clinically relevant st …
Genetic ablation of CD73 compromised HSPC transplantation in an acute setting without long-term changes in bone marrow HSPCs. Thus, t …
The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.
Christian S, Merz C, Evans L, Gradl S, Seidel H, Friberg A, Eheim A, Lejeune P, Brzezinka K, Zimmermann K, Ferrara S, Meyer H, Lesche R, Stoeckigt D, Bauser M, Haegebarth A, Sykes DB, Scadden DT, Losman JA, Janzer A. Christian S, et al. Among authors: scadden dt. Leukemia. 2019 Oct;33(10):2403-2415. doi: 10.1038/s41375-019-0461-5. Epub 2019 Apr 2. Leukemia. 2019. PMID: 30940908
Overcoming this differentiation arrest has the potential to improve the long-term survival of patients, as is the case in acute promyelocytic leukemia (APL), which is characterized by a chromosomal translocation involving the retinoic acid receptor alpha gene. ...
Overcoming this differentiation arrest has the potential to improve the long-term survival of patients, as is the case in acute promy …
Cell Cycle Analysis of Hematopoietic Stem and Progenitor Cells by Multicolor Flow Cytometry.
Galvin A, Weglarz M, Folz-Donahue K, Handley M, Baum M, Mazzola M, Litwa H, Scadden DT, Silberstein L. Galvin A, et al. Among authors: scadden dt. Curr Protoc Cytom. 2019 Jan;87(1):e50. doi: 10.1002/cpcy.50. Epub 2018 Oct 18. Curr Protoc Cytom. 2019. PMID: 30335223
Here, we describe a method where data acquisition parameters and fluorochrome combination for long-term HSC staining have been specifically designed for concurrent use with DAPI and Ki-67 antibodies. 2018 by John Wiley & Sons, Inc....
Here, we describe a method where data acquisition parameters and fluorochrome combination for long-term HSC staining have been specif …
Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1.
Schiroli G, Ferrari S, Conway A, Jacob A, Capo V, Albano L, Plati T, Castiello MC, Sanvito F, Gennery AR, Bovolenta C, Palchaudhuri R, Scadden DT, Holmes MC, Villa A, Sitia G, Lombardo A, Genovese P, Naldini L. Schiroli G, et al. Among authors: scadden dt. Sci Transl Med. 2017 Oct 11;9(411):eaan0820. doi: 10.1126/scitranslmed.aan0820. Sci Transl Med. 2017. PMID: 29021165
Finally, we optimized editing reagents and protocol for human HSPCs and attained the threshold of IL2RG editing in long-term repopulating cells predicted to safely rescue the disease, using clinically relevant HSPC sources and highly specific zinc finger nucleases or CRISP …
Finally, we optimized editing reagents and protocol for human HSPCs and attained the threshold of IL2RG editing in long-term repopula …
Distinct bone marrow blood vessels differentially regulate haematopoiesis.
Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung Y, Milo I, Poulos MG, Kalinkovich A, Ludin A, Kollet O, Shakhar G, Butler JM, Rafii S, Adams RH, Scadden DT, Lin CP, Lapidot T. Itkin T, et al. Among authors: scadden dt. Nature. 2016 Apr 21;532(7599):323-8. doi: 10.1038/nature17624. Epub 2016 Apr 13. Nature. 2016. PMID: 27074509 Free PMC article.
A functional consequence of high permeability of blood vessels is that exposure to blood plasma increases bone marrow HSPC ROS levels, augmenting their migration and differentiation, while compromising their long-term repopulation and survival. These findings may have rele …
A functional consequence of high permeability of blood vessels is that exposure to blood plasma increases bone marrow HSPC ROS levels, augme …
Tic-TACs: refreshing hair growth.
Kalaitzidis D, Scadden DT. Kalaitzidis D, et al. Among authors: scadden dt. Cell. 2014 May 8;157(4):769-70. doi: 10.1016/j.cell.2014.04.014. Cell. 2014. PMID: 24813602 Free PMC article.
Using the hair follicle as a model, Hsu at al. demonstrate that the transient-amplifying cells, downstream of stem cells and well-known cell producers, signal back to stem cells to maintain long-term regenerative capacity....
Using the hair follicle as a model, Hsu at al. demonstrate that the transient-amplifying cells, downstream of stem cells and well-known cell …
Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.
Cutler C, Multani P, Robbins D, Kim HT, Le T, Hoggatt J, Pelus LM, Desponts C, Chen YB, Rezner B, Armand P, Koreth J, Glotzbecker B, Ho VT, Alyea E, Isom M, Kao G, Armant M, Silberstein L, Hu P, Soiffer RJ, Scadden DT, Ritz J, Goessling W, North TE, Mendlein J, Ballen K, Zon LI, Antin JH, Shoemaker DD. Cutler C, et al. Among authors: scadden dt. Blood. 2013 Oct 24;122(17):3074-81. doi: 10.1182/blood-2013-05-503177. Epub 2013 Aug 30. Blood. 2013. PMID: 23996087 Free PMC article. Clinical Trial.
We observed encouraging trends in efficacy, with accelerated neutrophil recovery (17.5 vs 21 days, P = .045), coupled with preferential, long-term engraftment of the dmPGE2-treated UCB unit in 10 of 12 treated participants....
We observed encouraging trends in efficacy, with accelerated neutrophil recovery (17.5 vs 21 days, P = .045), coupled with preferential, lon …
Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells.
Samuel R, Daheron L, Liao S, Vardam T, Kamoun WS, Batista A, Buecker C, Schäfer R, Han X, Au P, Scadden DT, Duda DG, Fukumura D, Jain RK. Samuel R, et al. Among authors: scadden dt. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12774-9. doi: 10.1073/pnas.1310675110. Epub 2013 Jul 16. Proc Natl Acad Sci U S A. 2013. PMID: 23861493 Free PMC article.
Additionally, the durability of hiPS-derived blood vessels in vivo demonstrates a potential translation of this approach in long-term vascularization for tissue engineering and treatment of vascular diseases. ...
Additionally, the durability of hiPS-derived blood vessels in vivo demonstrates a potential translation of this approach in long-term …
27 results