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Long-term improvement in mdx cardiomyopathy after therapy with peptide-conjugated morpholino oligomers.
Jearawiriyapaisarn N, Moulton HM, Sazani P, Kole R, Willis MS. Jearawiriyapaisarn N, et al. Among authors: sazani p. Cardiovasc Res. 2010 Feb 1;85(3):444-53. doi: 10.1093/cvr/cvp335. Epub 2009 Oct 8. Cardiovasc Res. 2010. PMID: 19815563 Free PMC article.
By echocardiography and Doppler analysis of the mitral valve, we identified that PPMO treatment of mdx mice prevented the cardiac hypertrophy and diastolic dysfunction identified in sham-treated, age-matched mdx mice, characteristic of DMD patients early in the disease process, i …
By echocardiography and Doppler analysis of the mitral valve, we identified that PPMO treatment of mdx mice prevented the cardiac hypertroph …
Short-term and long-term modulation of gene expression by antisense therapeutics.
Sazani P, Vacek MM, Kole R. Sazani P, et al. Curr Opin Biotechnol. 2002 Oct;13(5):468-72. doi: 10.1016/s0958-1669(02)00366-x. Curr Opin Biotechnol. 2002. PMID: 12459339 Review.
To achieve effective modulation of gene expression by antisense oligonucleotides, novel oligonucleotide chemistries that do not promote RNase H degradation of target RNA are needed. In addition to short-term oligonucleotide effects, long-term gene regulation can be …
To achieve effective modulation of gene expression by antisense oligonucleotides, novel oligonucleotide chemistries that do not promote RNas …