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Position statement on the diagnosis and management of congenital pituitary deficiency in adults: the French National Diagnosis and Treatment Protocol (NDTP).
Castets S, Albarel F, Bachelot A, Brun G, Bouligand J, Briet C, Bui Quoc E, Cazabat C, Chabbert-Buffet C, Christin-Maitre S, Courtillot C, Cuny T, De Filippo G, Donadille B, Illouz F, Pellegrini I, Reznik Y, Saveanu A, Teissier N, Touraine P, Vantyghem MC, Vergier J, Léger J, Brue T, Reynaud R. Castets S, et al. Among authors: saveanu a. Ann Endocrinol (Paris). 2024 Mar 5:S0003-4266(24)00035-0. doi: 10.1016/j.ando.2024.03.001. Online ahead of print. Ann Endocrinol (Paris). 2024. PMID: 38452869 Free article.
Comorbidities, risk of complications and acute decompensation, and the impact on fertility and quality of life all require adaptative multidisciplinary care and long-term monitoring....
Comorbidities, risk of complications and acute decompensation, and the impact on fertility and quality of life all require adaptative multid …
Congenital Central Hypothyroidism Caused by a Novel IGSF1 Variant Identified in a French Family.
Fourneaux R, Castets S, Godefroy A, Grelet M, Abeillon-du Payrat J, Saveanu A, Castinetti F, Reynaud R. Fourneaux R, et al. Among authors: saveanu a. Horm Res Paediatr. 2022;95(3):296-303. doi: 10.1159/000524233. Epub 2022 Mar 29. Horm Res Paediatr. 2022. PMID: 35350016
Here, we describe four familial cases with a variable presentation due to a novel IGSF1 pathogenic variant. CASE PRESENTATION: In the index case, an investigation at birth of a suspected brain-lung-thyroid syndrome surprisingly revealed a central hypothyroidism. ...We sugg …
Here, we describe four familial cases with a variable presentation due to a novel IGSF1 pathogenic variant. CASE PRESENTATION: In the index …
Clinical lessons learned in constitutional hypopituitarism from two decades of experience in a large international cohort.
Jullien N, Saveanu A, Vergier J, Marquant E, Quentien MH, Castinetti F, Galon-Faure N, Brauner R, Marrakchi Turki Z, Tauber M, El Kholy M, Linglart A, Rodien P, Fedala NS, Bergada I, Cortet-Rudelli C, Polak M, Nicolino M, Stuckens C, Barlier A, Brue T, Reynaud R; Genhypopit Network. Jullien N, et al. Among authors: saveanu a. Clin Endocrinol (Oxf). 2021 Feb;94(2):277-289. doi: 10.1111/cen.14355. Epub 2020 Dec 21. Clin Endocrinol (Oxf). 2021. PMID: 33098107
CONCLUSION: This large international cohort highlights atypical phenotypic presentation of constitutional hypopituitarism, such as post pubertal presentation or adult progression of hormonal deficiencies. These results justify long-term follow-up, and the need for systemat …
CONCLUSION: This large international cohort highlights atypical phenotypic presentation of constitutional hypopituitarism, such as post pube …
Balance between somatostatin and D2 receptor expression drives TSH-secreting adenoma response to somatostatin analogues and dopastatins.
Gatto F, Barbieri F, Gatti M, Wurth R, Schulz S, Ravetti JL, Zona G, Culler MD, Saveanu A, Giusti M, Minuto F, Hofland LJ, Ferone D, Florio T. Gatto F, et al. Among authors: saveanu a. Clin Endocrinol (Oxf). 2012 Mar;76(3):407-14. doi: 10.1111/j.1365-2265.2011.04200.x. Clin Endocrinol (Oxf). 2012. PMID: 21848909
RESULTS: All patients showed significant TSH lowering to acute octreotide test, but a hormonal response to long-term treatment was observed in only two patients, showing a high sst(5) /sst(2) ratio. ...CONCLUSIONS: A high sst(5) /sst(2) ratio might be predictive of a posit …
RESULTS: All patients showed significant TSH lowering to acute octreotide test, but a hormonal response to long-term treatment was ob …
BIM-23A760, a chimeric molecule directed towards somatostatin and dopamine receptors, vs universal somatostatin receptors ligands in GH-secreting pituitary adenomas partial responders to octreotide.
Jaquet P, Gunz G, Saveanu A, Barlier A, Dufour H, Taylor J, Dong J, Kim S, Moreau JP, Culler MD. Jaquet P, et al. Among authors: saveanu a. J Endocrinol Invest. 2005;28(11 Suppl International):21-7. J Endocrinol Invest. 2005. PMID: 16625841
We report the comparative efficacy of a somatostatin receptor 1 and 5 subtypes (SSTR2 and SSTR5), and dopamine D2 (DAD2) compound, BIM-23A760, in suppressing GH secretion, in cell culture from human GH-secreting tumors, from patients partially responsive to long-term treat …
We report the comparative efficacy of a somatostatin receptor 1 and 5 subtypes (SSTR2 and SSTR5), and dopamine D2 (DAD2) compound, BIM-23A76 …
New SRIF analogs in the control of human pituitary adenomas: perspectives.
Jaquet P, Saveanu A, Barlier A. Jaquet P, et al. Among authors: saveanu a. J Endocrinol Invest. 2005;28(5 Suppl):14-8. J Endocrinol Invest. 2005. PMID: 16114269 Review.
Although the drugs of reference, octreotide and lanreotide, are widely used in the treatment of acromegaly, their long-term administration allows an effective control of both GH hypersecretion and IGF-I levels in about 60% of the patients. ...
Although the drugs of reference, octreotide and lanreotide, are widely used in the treatment of acromegaly, their long-term administr …
[Congenital hypopituitarism: when should transcription factor gene screenings be performed?].
Reynaud R, Barlier A, Chadli-Chaieb M, Saveanu A, Simonin G, Enjalbert A, Brue T. Reynaud R, et al. Among authors: saveanu a. Presse Med. 2004 Mar 27;33(6):400-5. doi: 10.1016/s0755-4982(04)98607-1. Presse Med. 2004. PMID: 15105786 Review. French.
They are due to mutations of transcription factors involved in the early steps of pituitary development (RIEG, HesX1, LHX4, LHX3, Prop1, POU1F1/Pit-1), and are associated with various phenotypes. FOR BETTER MANAGEMENT: Long-term follow-up of these patients and functional s …
They are due to mutations of transcription factors involved in the early steps of pituitary development (RIEG, HesX1, LHX4, LHX3, Prop1, POU …
A luteinizing hormone-, alpha-subunit- and prolactin-secreting pituitary adenoma responsive to somatostatin analogs: in vivo and in vitro studies.
Saveanu A, Morange-Ramos I, Gunz G, Dufour H, Enjalbert A, Jaquet P. Saveanu A, et al. Eur J Endocrinol. 2001 Jul;145(1):35-41. doi: 10.1530/eje.0.1450035. Eur J Endocrinol. 2001. PMID: 11415850
The endocrine evaluation showed high plasma levels of PRL, LH, and alpha-subunit inhibited by 65%, 65% and 33% respectively under octreotide test (200 microg, s.c.). Long-term treatment with slow release (SR) lanreotide (30 mg/10 days, i.m.) restored menstrual cycles and n …
The endocrine evaluation showed high plasma levels of PRL, LH, and alpha-subunit inhibited by 65%, 65% and 33% respectively under octreotide …