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Epilepsy and sleep disorders improve in adolescents and adults with Angelman syndrome: A multicenter study on 46 patients.
Sueri C, Ferlazzo E, Elia M, Bonanni P, Randazzo G, Gasparini S, D'Agostino T, Sapone AR, Ascoli M, Bellavia MA, Cianci V, Gambardella A, Labate A, Aguglia U. Sueri C, et al. Among authors: sapone ar. Epilepsy Behav. 2017 Oct;75:225-229. doi: 10.1016/j.yebeh.2017.07.041. Epub 2017 Aug 19. Epilepsy Behav. 2017. PMID: 28827041
These reports provide conflicting results. The aim of this study was to assess the long-term outcome of epilepsy, sleep disorders, and EEG in a vast series of AS subjects. ...
These reports provide conflicting results. The aim of this study was to assess the long-term outcome of epilepsy, sleep disorders, an …
Celiac Disease and Nonceliac Gluten Sensitivity: A Review.
Leonard MM, Sapone A, Catassi C, Fasano A. Leonard MM, et al. Among authors: sapone a. JAMA. 2017 Aug 15;318(7):647-656. doi: 10.1001/jama.2017.9730. JAMA. 2017. PMID: 28810029 Review.
Although both conditions are treated with a gluten-free diet, distinguishing between celiac disease and nonceliac gluten sensitivity is important for long-term therapy. Patients with celiac disease should be followed up closely for dietary adherence, nutritional deficienci …
Although both conditions are treated with a gluten-free diet, distinguishing between celiac disease and nonceliac gluten sensitivity is impo …
Pathophysiology of non-celiac gluten sensitivity: where are we now?
Caio G, Riegler G, Patturelli M, Facchiano A, DE Magistris L, Sapone A. Caio G, et al. Among authors: sapone a. Minerva Gastroenterol Dietol. 2017 Mar;63(1):16-21. doi: 10.23736/S1121-421X.16.02346-1. Epub 2016 Nov 3. Minerva Gastroenterol Dietol. 2017. PMID: 27808487 Review.
Non-celiac gluten sensitivity (NCGS) is the term used to describe individuals complaining of intestinal and extra-intestinal symptoms related to gluten ingestion and rapidly improving after its withdrawal, and in which both celiac disease (CD) and wheat allergy (WA) were p …
Non-celiac gluten sensitivity (NCGS) is the term used to describe individuals complaining of intestinal and extra-intestinal symptoms …
Disruption of redox homeostasis and carcinogen metabolizing enzymes changes by administration of vitamin E to rats.
Vivarelli F, Canistro D, Franchi P, Sapone A, Vornoli A, Della Croce C, Longo V, Lucarini M, Paolini M. Vivarelli F, et al. Among authors: sapone a. Life Sci. 2016 Jan 15;145:166-73. doi: 10.1016/j.lfs.2015.12.033. Epub 2015 Dec 17. Life Sci. 2016. PMID: 26702769
AIMS: A large meta-analysis of randomized clinical trials has seriously questioned chemoprevention based on vitamins including vitamin E (VE), and an increased risk for cancer among long-term users was actually seen. However, the mechanism underlying these findings still r …
AIMS: A large meta-analysis of randomized clinical trials has seriously questioned chemoprevention based on vitamins including vitamin E (VE …
On enzyme-based anticancer molecular dietary manipulations.
Sapone A, Canistro D, Melega S, Moles R, Vivarelli F, Paolini M. Sapone A, et al. J Biomed Biotechnol. 2012;2012:790987. doi: 10.1155/2012/790987. Epub 2012 Sep 20. J Biomed Biotechnol. 2012. PMID: 23049243 Free PMC article. Review.
Here, we show that the idea that the physiological roles of specific catalysts may be easily manipulated by regular long-term administration of isolated nutrients and other chemicals derived from food plants is not viable. ...
Here, we show that the idea that the physiological roles of specific catalysts may be easily manipulated by regular long-term adminis …
Glucoraphanin, the bioprecursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, induces phase-I xenobiotic metabolizing enzymes and increases free radical generation in rat liver.
Perocco P, Bronzetti G, Canistro D, Valgimigli L, Sapone A, Affatato A, Pedulli GF, Pozzetti L, Broccoli M, Iori R, Barillari J, Sblendorio V, Legator MS, Paolini M, Abdel-Rahman SZ. Perocco P, et al. Among authors: sapone a. Mutat Res. 2006 Mar 20;595(1-2):125-36. doi: 10.1016/j.mrfmmm.2005.11.007. Mutat Res. 2006. PMID: 16442570
Epidemiological and animal studies linking high fruit and vegetable consumption to lower cancer risk have strengthened the belief that long-term administration of isolated naturally occurring dietary constituents could reduce the risk of cancer. ...Concomitant with this Ph …
Epidemiological and animal studies linking high fruit and vegetable consumption to lower cancer risk have strengthened the belief that long- …
Induction and suppression of cytochrome P450 isoenzymes and generation of oxygen radicals by procymidone in liver, kidney and lung of CD1 mice.
Sapone A, Affatato A, Canistro D, Broccoli M, Trespidi S, Pozzetti L, Biagi GL, Cantelli-Forti G, Paolini M. Sapone A, et al. Mutat Res. 2003 Jun 19;527(1-2):67-80. doi: 10.1016/s0027-5107(03)00055-1. Mutat Res. 2003. PMID: 12787915
Although chronic administration of procymidone (a widely used dicarboximide fungicide) leads to an increased incidence of liver tumors in mice, short-term genotoxicity studies proved negative. As cytochrome P450 (CYP) induction has been linked to non-genotoxic carcinogenes …
Although chronic administration of procymidone (a widely used dicarboximide fungicide) leads to an increased incidence of liver tumors in mi …
Beta-carotene: a cancer chemopreventive agent or a co-carcinogen?
Paolini M, Abdel-Rahman SZ, Sapone A, Pedulli GF, Perocco P, Cantelli-Forti G, Legator MS. Paolini M, et al. Among authors: sapone a. Mutat Res. 2003 Jun;543(3):195-200. doi: 10.1016/s1383-5742(03)00002-4. Mutat Res. 2003. PMID: 12787812
The data presented provide convincing evidence of the harmful properties of this compound if given alone to smokers, or to individuals exposed to environmental carcinogens, as a micronutrient supplement. This has now been directly verified in a medium-term cancer transform …
The data presented provide convincing evidence of the harmful properties of this compound if given alone to smokers, or to individuals expos …
In vitro induction of benzo(a)pyrene cell-transforming activity by the glucosinolate gluconasturtiin found in cruciferous vegetables.
Perocco P, Iori R, Barillari J, Broccoli M, Sapone A, Affatato A, Paolini M. Perocco P, et al. Among authors: sapone a. Cancer Lett. 2002 Oct 8;184(1):65-71. doi: 10.1016/s0304-3835(02)00194-5. Cancer Lett. 2002. PMID: 12104049
Cytotoxic and cell-transforming activity of gluconasturtiin (GNST), a promising chemopreventive agent commonly found in human diet, was studied in a medium-term bioassay utilizing BALB/c 3T3 cells. We also assessed whether GNST coupled with myrosinase, thus yielding produc …
Cytotoxic and cell-transforming activity of gluconasturtiin (GNST), a promising chemopreventive agent commonly found in human diet, was stud …