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Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy.
Estrada JC, Torres Y, Benguría A, Dopazo A, Roche E, Carrera-Quintanar L, Pérez RA, Enríquez JA, Torres R, Ramírez JC, Samper E, Bernad A. Estrada JC, et al. Among authors: samper e. Cell Death Dis. 2013 Jun 27;4(6):e691. doi: 10.1038/cddis.2013.211. Cell Death Dis. 2013. PMID: 23807220 Free PMC article.
Overexpression of the telomerase catalytic subunit (human telomerase reverse transcriptase, hTERT) inhibited senescence, markedly reducing the levels of aneuploidy and preventing the dysregulation of ploidy-controlling genes. hMSC-replicative senescence was accompanied by an incr …
Overexpression of the telomerase catalytic subunit (human telomerase reverse transcriptase, hTERT) inhibited senescence, markedly reducing t …
Increased learning and brain long-term potentiation in aged mice lacking DNA polymerase mu.
Lucas D, Delgado-García JM, Escudero B, Albo C, Aza A, Acín-Pérez R, Torres Y, Moreno P, Enríquez JA, Samper E, Blanco L, Fairén A, Bernad A, Gruart A. Lucas D, et al. Among authors: samper e. PLoS One. 2013;8(1):e53243. doi: 10.1371/journal.pone.0053243. Epub 2013 Jan 3. PLoS One. 2013. PMID: 23301049 Free PMC article.
DNA polymerase is a novel accessory partner for the non-homologous end-joining DNA repair pathway for double-strand breaks, and its deficiency causes reduced DNA repair. Using associative learning and long-term potentiation experiments, we demonstrate that Pol(-/-) mice, h …
DNA polymerase is a novel accessory partner for the non-homologous end-joining DNA repair pathway for double-strand breaks, and its deficien …
Assessment of the protective effects of oral tocotrienols in arginine chronic-like pancreatitis.
González AM, Garcia T, Samper E, Rickmann M, Vaquero EC, Molero X. González AM, et al. Among authors: samper e. Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G846-55. doi: 10.1152/ajpgi.00485.2010. Epub 2011 Aug 18. Am J Physiol Gastrointest Liver Physiol. 2011. PMID: 21852363 Free article.
TRF reduced protease and Smad3 activation, collagen, and fibronectin. alpha-SMA increased and GFAP diminished in arginine pancreatitis, consistent with long-term stellate cell activation, and TRF reverted these changes to basal. ...
TRF reduced protease and Smad3 activation, collagen, and fibronectin. alpha-SMA increased and GFAP diminished in arginine pancreatitis, cons …
Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells.
Samper E, Fernández P, Eguía R, Martín-Rivera L, Bernad A, Blasco MA, Aracil M. Samper E, et al. Blood. 2002 Apr 15;99(8):2767-75. doi: 10.1182/blood.v99.8.2767. Blood. 2002. PMID: 11929765 Free article.
In serial and competitive transplantations, mTerc(-/-) BM stem cells show reduced long-term repopulating capacity, concomitant with an increase in genetic instability compared with wildtype cells. ...In summary, our results demonstrate that late-generation mTerc(-/-) BM ce …
In serial and competitive transplantations, mTerc(-/-) BM stem cells show reduced long-term repopulating capacity, concomitant with a …