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Page 1
Emerging pharmacotherapy of tinnitus.
Langguth B, Salvi R, Elgoyhen AB. Langguth B, et al. Among authors: salvi r. Expert Opin Emerg Drugs. 2009 Dec;14(4):687-702. doi: 10.1517/14728210903206975. Expert Opin Emerg Drugs. 2009. PMID: 19712015 Free PMC article. Review.
None of the investigated drugs have demonstrated providing replicable long-term reduction of tinnitus impact in the majority of patients in excess of placebo effects. ...
None of the investigated drugs have demonstrated providing replicable long-term reduction of tinnitus impact in the majority of patie …
Unexpected Consequences of Noise-Induced Hearing Loss: Impaired Hippocampal Neurogenesis, Memory, and Stress.
Manohar S, Chen GD, Ding D, Liu L, Wang J, Chen YC, Chen L, Salvi R. Manohar S, et al. Among authors: salvi r. Front Integr Neurosci. 2022 May 10;16:871223. doi: 10.3389/fnint.2022.871223. eCollection 2022. Front Integr Neurosci. 2022. PMID: 35619926 Free PMC article. Review.
More traumatic sound exposures that result in permanent NIHL chronically suppresses cell proliferation and neurogenesis in the hippocampus; these structural changes are associated with long-term spatial memory deficits. Hippocampal neurons, which contain numerous glucocort …
More traumatic sound exposures that result in permanent NIHL chronically suppresses cell proliferation and neurogenesis in the hippocampus; …
Underlying mechanisms of tinnitus: review and clinical implications.
Henry JA, Roberts LE, Caspary DM, Theodoroff SM, Salvi RJ. Henry JA, et al. Among authors: salvi rj. J Am Acad Audiol. 2014 Jan;25(1):5-22; quiz 126. doi: 10.3766/jaaa.25.1.2. J Am Acad Audiol. 2014. PMID: 24622858 Free PMC article. Review.
Neural changes can occur at the level of synapses between inner hair cells and the auditory nerve and within multiple levels of the central auditory pathway. Long-term maintenance of tinnitus is likely a function of a complex network of structures involving central auditor …
Neural changes can occur at the level of synapses between inner hair cells and the auditory nerve and within multiple levels of the central …
Cochlear spiral ganglion neuron degeneration following cyclodextrin-induced hearing loss.
Ding D, Jiang H, Salvi R. Ding D, et al. Among authors: salvi r. Hear Res. 2021 Feb;400:108125. doi: 10.1016/j.heares.2020.108125. Epub 2020 Nov 27. Hear Res. 2021. PMID: 33302057
To test this hypothesis, we treated rats subcutaneously with 1, 2, 3 or 4 g/kg of HPbetaCD and waited for 8-weeks to assess the long-term histological consequences. Our new results indicate that the two highest doses of HPbetaCD caused extensive damage not only to OHC, but …
To test this hypothesis, we treated rats subcutaneously with 1, 2, 3 or 4 g/kg of HPbetaCD and waited for 8-weeks to assess the long-term …
Noise-induced hearing loss alters hippocampal glucocorticoid receptor expression in rats.
Hayes SH, Manohar S, Majumdar A, Allman BL, Salvi R. Hayes SH, et al. Among authors: salvi r. Hear Res. 2019 Aug;379:43-51. doi: 10.1016/j.heares.2019.04.013. Epub 2019 Apr 26. Hear Res. 2019. PMID: 31071644 Free PMC article.
Previously, we demonstrated that noise-induced hearing loss causes a significant long-term reduction in hippocampal neurogenesis and cell proliferation. Given the known suppressive effects of stress hormones on neurogenesis, the goal of the present study was to determine i …
Previously, we demonstrated that noise-induced hearing loss causes a significant long-term reduction in hippocampal neurogenesis and …
Intermittent Low-level Noise Causes Negative Neural Gain in the Inferior Colliculus.
Sheppard A, Liu X, Alkharabsheh A, Chen GD, Salvi R. Sheppard A, et al. Among authors: salvi r. Neuroscience. 2019 May 21;407:135-145. doi: 10.1016/j.neuroscience.2018.11.013. Epub 2018 Nov 17. Neuroscience. 2019. PMID: 30458217
The central auditory system shows a remarkable ability to rescale its neural representation of loudness following long-term, low-level acoustic exposures; even when the noise is presented intermittently. ...
The central auditory system shows a remarkable ability to rescale its neural representation of loudness following long-term, low-leve …
Dissociation between Cerebellar and Cerebral Neural Activities in Humans with Long-Term Bilateral Sensorineural Hearing Loss.
Xu XM, Jiao Y, Tang TY, Zhang J, Lu CQ, Luan Y, Salvi R, Teng GJ. Xu XM, et al. Among authors: salvi r. Neural Plast. 2019 Mar 27;2019:8354849. doi: 10.1155/2019/8354849. eCollection 2019. Neural Plast. 2019. PMID: 31049056 Free PMC article.
Abnormal neural activity in the cerebellum has been implicated in hearing impairments, but the effects of long-term hearing loss on cerebellar function are poorly understood. To further explore the role of long-term bilateral sensorineural hearing loss on cerebellar …
Abnormal neural activity in the cerebellum has been implicated in hearing impairments, but the effects of long-term hearing loss on c …
Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice.
Han C, Ding D, Lopez MC, Manohar S, Zhang Y, Kim MJ, Park HJ, White K, Kim YH, Linser P, Tanokura M, Leeuwenburgh C, Baker HV, Salvi RJ, Someya S. Han C, et al. Among authors: salvi rj. J Neurosci. 2016 Nov 2;36(44):11308-11319. doi: 10.1523/JNEUROSCI.2493-16.2016. J Neurosci. 2016. PMID: 27807171 Free PMC article.
., 2013; Chen et al., 2015). Here, we investigated the effects of long-term voluntary wheel running (WR) on age-related hearing loss (AHL) in CBA/CaJ mice, a well established model of AHL (Zheng et al., 1999). ...Given that SV holds numerous capillaries that are essential …
., 2013; Chen et al., 2015). Here, we investigated the effects of long-term voluntary wheel running (WR) on age-related hearing loss …
Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence.
Werner CT, Mitra S, Auerbach BD, Wang ZJ, Martin JA, Stewart AF, Gobira PH, Iida M, An C, Cobb MM, Caccamise A, Salvi RJ, Neve RL, Gancarz AM, Dietz DM. Werner CT, et al. Among authors: salvi rj. Proc Natl Acad Sci U S A. 2020 Oct 20;117(42):26460-26469. doi: 10.1073/pnas.2006133117. Epub 2020 Oct 5. Proc Natl Acad Sci U S A. 2020. PMID: 33020308 Free PMC article.
Therefore, we examined synaptic strength in the DH during prolonged abstinence and observed an increase in moderate long-term potentiation (LTP) in cocaine-treated rats compared to saline controls. ...
Therefore, we examined synaptic strength in the DH during prolonged abstinence and observed an increase in moderate long-term potenti …
Sensorineural hearing loss and cognitive impairments: Contributions of thalamus using multiparametric MRI.
Xu XM, Jiao Y, Tang TY, Zhang J, Lu CQ, Salvi R, Teng GJ. Xu XM, et al. Among authors: salvi r. J Magn Reson Imaging. 2019 Sep;50(3):787-797. doi: 10.1002/jmri.26665. Epub 2019 Jan 29. J Magn Reson Imaging. 2019. PMID: 30694013
STUDY TYPE: Cross-sectional study. SUBJECTS: Thirty-seven bilateral long-term SNHL patients and 38 well-matched controls. FIELD STRENGTH: 3 T/BOLD, T(1) -weighted imaging, arterial spin labeling (ASL). ...
STUDY TYPE: Cross-sectional study. SUBJECTS: Thirty-seven bilateral long-term SNHL patients and 38 well-matched controls. FIELD STREN …
43 results