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Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS.
Sahadevan S, Hembach KM, Tantardini E, Pérez-Berlanga M, Hruska-Plochan M, Megat S, Weber J, Schwarz P, Dupuis L, Robinson MD, De Rossi P, Polymenidou M. Sahadevan S, et al. Nat Commun. 2021 May 21;12(1):3027. doi: 10.1038/s41467-021-23188-8. Nat Commun. 2021. PMID: 34021139 Free PMC article.
Significant increase of synaptic FUS during early disease in a mouse model of ALS was accompanied by alterations in density and size of GABAergic synapses. mRNAs abnormally accumulated at the synapses of 6-month-old ALS-FUS mice were enriched for FUS targets and correlated with t …
Significant increase of synaptic FUS during early disease in a mouse model of ALS was accompanied by alterations in density and size of GABA …