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Mortality and morbidity in pre-sensitized pediatric heart transplant recipients with a positive donor crossmatch utilizing peri-operative plasmapheresis and cytolytic therapy.
Holt DB, Lublin DM, Phelan DL, Boslaugh SE, Gandhi SK, Huddleston CB, Saffitz JE, Canter CE. Holt DB, et al. Among authors: saffitz je. J Heart Lung Transplant. 2007 Sep;26(9):876-82. doi: 10.1016/j.healun.2007.07.011. J Heart Lung Transplant. 2007. PMID: 17845925
CONCLUSIONS: Heart transplantation in pre-sensitized pediatric recipients with a CDC-positive donor/recipient crossmatch may result in reasonable short-term survival, but with a high frequency of early rejection, often with hemodynamic compromise....
CONCLUSIONS: Heart transplantation in pre-sensitized pediatric recipients with a CDC-positive donor/recipient crossmatch may result in reaso …
Local maximal stress hypothesis and computational plaque vulnerability index for atherosclerotic plaque assessment.
Tang D, Yang C, Zheng J, Woodard PK, Saffitz JE, Petruccelli JD, Sicard GA, Yuan C. Tang D, et al. Among authors: saffitz je. Ann Biomed Eng. 2005 Dec;33(12):1789-801. doi: 10.1007/s10439-005-8267-1. Ann Biomed Eng. 2005. PMID: 16389527 Free PMC article.
Our initial results based on 34 2D MRI slices from 14 human coronary plaque samples indicate that CPVI plaque assessment has an 85% agreement rate (91% if the square root of stress values is used) with assessment given by histopathological analysis. Large-scale and long-term …
Our initial results based on 34 2D MRI slices from 14 human coronary plaque samples indicate that CPVI plaque assessment has an 85% agreemen …
PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.
Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP. Leone TC, et al. Among authors: saffitz je. PLoS Biol. 2005 Apr;3(4):e101. doi: 10.1371/journal.pbio.0030101. Epub 2005 Mar 15. PLoS Biol. 2005. PMID: 15760270 Free PMC article.
The PGC-1alpha(-/-) mice were unable to maintain core body temperature following exposure to cold, consistent with an altered thermogenic response. Following short-term starvation, PGC-1alpha(-/-) mice develop hepatic steatosis due to a combination of reduced mitochondrial …
The PGC-1alpha(-/-) mice were unable to maintain core body temperature following exposure to cold, consistent with an altered thermogenic re …
Non-ischemic left ventricular dysfunction after pediatric cardiac transplantation: treatment with plasmapheresis and OKT3.
McOmber D, Ibrahim J, Lublin DM, Saffitz JE, Ong-Simon C, Mendeloff EN, Huddleston CB, Canter CE. McOmber D, et al. Among authors: saffitz je. J Heart Lung Transplant. 2004 May;23(5):552-7. doi: 10.1016/S1053-2498(03)00308-5. J Heart Lung Transplant. 2004. PMID: 15135370
Survival to hospital discharge occurred in 11 of 13 (85%) patients. Long-term patient survival, however, was only 50% at 24 months after presentation with a first episode of acquired left ventricular dysfunction. CONCLUSIONS: Use of plasmapheresis, OKT3, cyclophosphamide a …
Survival to hospital discharge occurred in 11 of 13 (85%) patients. Long-term patient survival, however, was only 50% at 24 months af …
Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis.
Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros DM, Kelly DP. Lehman JJ, et al. Among authors: saffitz je. J Clin Invest. 2000 Oct;106(7):847-56. doi: 10.1172/JCI10268. J Clin Invest. 2000. PMID: 11018072 Free PMC article.
We found that PGC-1 gene expression is induced in the mouse heart after birth and in response to short-term fasting, conditions known to increase cardiac mitochondrial energy production. ...
We found that PGC-1 gene expression is induced in the mouse heart after birth and in response to short-term fasting, condition …
Use of single internal mammary artery grafts in older patients.
Wareing TH, Saffitz JE, Kouchoukos NT. Wareing TH, et al. Among authors: saffitz je. Circulation. 1990 Nov;82(5 Suppl):IV224-8. Circulation. 1990. PMID: 2225408
We conclude that the use of the internal mammary artery for bypass grafting in older patients is safe and may provide long-term benefit....
We conclude that the use of the internal mammary artery for bypass grafting in older patients is safe and may provide long-term benef …