Targeting mitochondrial hexokinases increases efficacy of histone deacetylase inhibitors in solid tumor models.
McDonald AJ, Curt KM, Patel RP, Kozlowski H, Sackett DL, Robey RW, Gottesman MM, Bates SE.
McDonald AJ, et al. Among authors: sackett dl.
Exp Cell Res. 2019 Feb 15;375(2):106-112. doi: 10.1016/j.yexcr.2018.12.012. Epub 2018 Dec 21.
Exp Cell Res. 2019.
PMID: 30579954
Free PMC article.
Cancer cell lines derived from breast, kidney, lung, colon or ovarian cancers were treated with a short-term exposure to 25 ng/ml romidepsin combined with either clotrimazole or bifonazole. ...Mitochondrial hexokinase 1 levels increased 2-fold or less. Our work suggests th …
Cancer cell lines derived from breast, kidney, lung, colon or ovarian cancers were treated with a short-term exposure to 25 ng/ml rom …