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Targeting mitochondrial hexokinases increases efficacy of histone deacetylase inhibitors in solid tumor models.
McDonald AJ, Curt KM, Patel RP, Kozlowski H, Sackett DL, Robey RW, Gottesman MM, Bates SE. McDonald AJ, et al. Among authors: sackett dl. Exp Cell Res. 2019 Feb 15;375(2):106-112. doi: 10.1016/j.yexcr.2018.12.012. Epub 2018 Dec 21. Exp Cell Res. 2019. PMID: 30579954 Free PMC article.
Cancer cell lines derived from breast, kidney, lung, colon or ovarian cancers were treated with a short-term exposure to 25 ng/ml romidepsin combined with either clotrimazole or bifonazole. ...Mitochondrial hexokinase 1 levels increased 2-fold or less. Our work suggests th …
Cancer cell lines derived from breast, kidney, lung, colon or ovarian cancers were treated with a short-term exposure to 25 ng/ml rom …
Analysis and reporting of factorial trials: a systematic review.
McAlister FA, Straus SE, Sackett DL, Altman DG. McAlister FA, et al. Among authors: sackett dl. JAMA. 2003 May 21;289(19):2545-53. doi: 10.1001/jama.289.19.2545. JAMA. 2003. PMID: 12759326 Review.
To identify trials missed by the electronic search, we performed a hand search of English-language trials in a defined topic area (using the term myocardial ischemia [exp]) listed in MEDLINE (1966-2002), EMBASE (1980-2002), and the Cochrane Controlled Trials Register, as w …
To identify trials missed by the electronic search, we performed a hand search of English-language trials in a defined topic area (using the …
Does a mailed continuing education program improve physician performance? Results of a randomized trial in antihypertensive care.
Evans CE, Haynes RB, Birkett NJ, Gilbert JR, Taylor DW, Sackett DL, Johnston ME, Hewson SA. Evans CE, et al. Among authors: sackett dl. JAMA. 1986 Jan 24-31;255(4):501-4. JAMA. 1986. PMID: 3941533 Clinical Trial.
Although formal pretesting documented that the program led to significant improvements in physician knowledge over the short term, the current study showed no lasting effect on physician knowledge (mean scores on an end-of-study questionnaire were 50% and 52% for study and …
Although formal pretesting documented that the program led to significant improvements in physician knowledge over the short term, th …
A cost-effectiveness analysis of alternative approaches for long-term treatment of proximal venous thrombosis.
Hull RD, Raskob GE, Hirsh J, Sackett DL. Hull RD, et al. Among authors: sackett dl. JAMA. 1984 Jul 13;252(2):235-9. JAMA. 1984. PMID: 6427492 Clinical Trial.
Recent data from randomized trials have provided a clear understanding of the effectiveness and safety of differing long-term anticoagulant therapies for proximal vein thrombosis. An issue that has not been addressed is their cost-effectiveness. We have performed a cost-ef …
Recent data from randomized trials have provided a clear understanding of the effectiveness and safety of differing long-term anticoa …
The family physician and the periodic health examination.
Sackett DL. Sackett DL. Can Fam Physician. 1972 Aug;18(8):61-5. Can Fam Physician. 1972. PMID: 20468802 Free PMC article.
Such elements as early detection, risk factors, health behavior, disease outcome, evaluation methods and effects of long term therapy are considered, the conclusion being that while screening has some value, existing programs have little hope of reducing risk or even maint …
Such elements as early detection, risk factors, health behavior, disease outcome, evaluation methods and effects of long term therapy …