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EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues.
Thapa P, Stewart R, Sepela RJ, Vivas O, Parajuli LK, Lillya M, Fletcher-Taylor S, Cohen BE, Zito K, Sack JT. Thapa P, et al. Among authors: sack jt. J Gen Physiol. 2021 Nov 1;153(11):e202012858. doi: 10.1085/jgp.202012858. Epub 2021 Sep 28. J Gen Physiol. 2021. PMID: 34581724 Free PMC article.
We synthesized GxTX-594, a variant of the peptidyl tarantula toxin guangxitoxin-1E, conjugated to a fluorophore optimal for two-photon excitation imaging through light-scattering tissue. We term this tool EVAP (Endogenous Voltage-sensor Activity Probe). GxTX-594 targets th …
We synthesized GxTX-594, a variant of the peptidyl tarantula toxin guangxitoxin-1E, conjugated to a fluorophore optimal for two-photon excit …
Patient Experiences and Outcomes of a Telehealth Clinical Care Pathway for Postoperative Inflammatory Bowel Disease Patients.
Zand A, Nguyen A, Stokes Z, van Deen W, Lightner A, Platt A, Jacobs R, Reardon S, Kane E, Sack J, Hommes D. Zand A, et al. Among authors: sack j. Telemed J E Health. 2020 Jul;26(7):889-897. doi: 10.1089/tmj.2019.0102. Epub 2019 Oct 31. Telemed J E Health. 2020. PMID: 31670610
Background:Despite advancements in treatment for inflammatory bowel disease (IBD), surgery remains inevitable for patients and IBD management is costly.Introduction:Frequent postoperative monitoring is needed for early detection of both short-term complications and long- …
Background:Despite advancements in treatment for inflammatory bowel disease (IBD), surgery remains inevitable for patients and IBD managemen …
Tentorial sling for microvascular decompression in patients with trigeminal neuralgia: a description of operative technique and clinical outcomes.
Steinberg JA, Sack J, Wilson B, Weingarten D, Carter B, Khalessi A, Ben-Haim S, Alksne J. Steinberg JA, et al. Among authors: sack j. J Neurosurg. 2018 Apr 20;130(4):1315-1320. doi: 10.3171/2017.10.JNS17971. J Neurosurg. 2018. PMID: 29676696
Although the authors' preliminary results parallel the historical cure rate, further outcome data are required to assess long-term durability of this method....
Although the authors' preliminary results parallel the historical cure rate, further outcome data are required to assess long-term du …
Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.
Gong H, Weinstein DS, Lu Z, Duan JJ, Stachura S, Haque L, Karmakar A, Hemagiri H, Raut DK, Gupta AK, Khan J, Camac D, Sack JS, Pudzianowski A, Wu DR, Yarde M, Shen DR, Borowski V, Xie JH, Sun H, D'Arienzo C, Dabros M, Galella MA, Wang F, Weigelt CA, Zhao Q, Foster W, Somerville JE, Salter-Cid LM, Barrish JC, Carter PH, Dhar TGM. Gong H, et al. Among authors: sack js. Bioorg Med Chem Lett. 2018 Jan 15;28(2):85-93. doi: 10.1016/j.bmcl.2017.12.006. Epub 2017 Dec 5. Bioorg Med Chem Lett. 2018. PMID: 29233651
Pharmacodynamic (PD) data for compound 35 in an IL-23 induced IL-17 mouse model is discussed along with the implications of a high Y(max) in the PXR assay for long term preclinical pharmacokinetic (PK) studies....
Pharmacodynamic (PD) data for compound 35 in an IL-23 induced IL-17 mouse model is discussed along with the implications of a high Y(max) in …
Fungal endotipsitis: A case report and literature review.
McCarty TR, Sack J, Syed B, Kim R, Njei B. McCarty TR, et al. Among authors: sack j. J Dig Dis. 2017 Apr;18(4):237-240. doi: 10.1111/1751-2980.12451. J Dig Dis. 2017. PMID: 28127943 Free PMC article. Review.
Endotipsitis is a broad term used to describe sustained and clinically significant bacteremia or fungemia from a suspected vegetation or thrombus within the transjugular intrahepatic portosytemic shunt (TIPS) device. ...
Endotipsitis is a broad term used to describe sustained and clinically significant bacteremia or fungemia from a suspected vegetation …
A nationwide 2010-2012 analysis of U.S. health care utilization in inflammatory bowel diseases.
van Deen WK, van Oijen MG, Myers KD, Centeno A, Howard W, Choi JM, Roth BE, McLaughlin EM, Hollander D, Wong-Swanson B, Sack J, Ong MK, Ha CY, Esrailian E, Hommes DW. van Deen WK, et al. Among authors: sack j. Inflamm Bowel Dis. 2014 Oct;20(10):1747-53. doi: 10.1097/MIB.0000000000000139. Inflamm Bowel Dis. 2014. PMID: 25137415
RESULTS: A disproportionate usage of aminosalicylates in Crohn's disease (42%), frequent corticosteroid use (46%, with 9% long-term users), and low rates of corticosteroid-sparing drugs (thiopurines 15%; methotrexate 2.7%) were observed. ...
RESULTS: A disproportionate usage of aminosalicylates in Crohn's disease (42%), frequent corticosteroid use (46%, with 9% long-term u …
Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.
Speca DJ, Ogata G, Mandikian D, Bishop HI, Wiler SW, Eum K, Wenzel HJ, Doisy ET, Matt L, Campi KL, Golub MS, Nerbonne JM, Hell JW, Trainor BC, Sack JT, Schwartzkroin PA, Trimmer JS. Speca DJ, et al. Among authors: sack jt. Genes Brain Behav. 2014 Apr;13(4):394-408. doi: 10.1111/gbb.12120. Epub 2014 Mar 7. Genes Brain Behav. 2014. PMID: 24494598 Free PMC article.
Field recordings from hippocampal slices of Kv2.1(-/-) mice reveal hyperexcitability in response to the convulsant bicuculline, and epileptiform activity in response to stimulation. In Kv2.1(-/-) mice, long-term potentiation at the Schaffer collateral - CA1 synapse is decr …
Field recordings from hippocampal slices of Kv2.1(-/-) mice reveal hyperexcitability in response to the convulsant bicuculline, and epilepti …
Clinical and genetic characteristics of congenital hypothyroidism due to mutations in the thyroid peroxidase (TPO) gene in Israelis.
Tenenbaum-Rakover Y, Mamanasiri S, Ris-Stalpers C, German A, Sack J, Allon-Shalev S, Pohlenz J, Refetoff S. Tenenbaum-Rakover Y, et al. Among authors: sack j. Clin Endocrinol (Oxf). 2007 May;66(5):695-702. doi: 10.1111/j.1365-2265.2007.02804.x. Epub 2007 Mar 23. Clin Endocrinol (Oxf). 2007. PMID: 17381485
The high rate of development of multinodular glands (MNGs) in our cohort of patients indicates the need for long-term follow-up of patients with TPO gene mutations....
The high rate of development of multinodular glands (MNGs) in our cohort of patients indicates the need for long-term follow-up of pa …
Postpartum maternal hyperthyrotropinemia in an area in which iodine supplementation is required.
Sack J, Goldstein A, Charpak N, Rozin A, Ruiz-Pelaez JG, Figueroa de Calume Z, Charpak Y, Weller A. Sack J, et al. Thyroid. 2003 Oct;13(10):959-64. doi: 10.1089/105072503322511364. Thyroid. 2003. PMID: 14611705 Clinical Trial.
We studied thyrotropin (TSH) levels in mothers of premature and low-birth-weight infants in Colombia, where iodized salt supplements the diet to correct iodine deficiency. ...Initially, mothers had high TSH levels (i.e., TSH > 10 mU/L in half the mothers at the first as …
We studied thyrotropin (TSH) levels in mothers of premature and low-birth-weight infants in Colombia, where iodized salt supplements …
Longitudinal assessment of pituitary-thyroid axis and adrenal function in preterm infants raised by 'kangaroo mother care'.
Weller A, Rozin A, Goldstein A, Charpak N, Ruiz-Pelaez JG, Figueroa de Calume Z, Charpak Y, Sack J. Weller A, et al. Among authors: sack j. Horm Res. 2002;57(1-2):22-6. doi: 10.1159/000057942. Horm Res. 2002. PMID: 12006715 Clinical Trial.
The levels of 17alpha-hydroxy-progesterone (17-OHP), thyroxine-stimulating hormone (TSH) and thyroxine (T(4)) were assessed by radioimmunoassay. Birth weight (<1,800 or > or =1,800 g) and prenatal maternal corticosteroid treatment were taken into account in the analy …
The levels of 17alpha-hydroxy-progesterone (17-OHP), thyroxine-stimulating hormone (TSH) and thyroxine (T(4)) were assessed by radioimmunoas …
30 results