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Structure of the mechanically activated ion channel Piezo1.
Saotome K, Murthy SE, Kefauver JM, Whitwam T, Patapoutian A, Ward AB. Saotome K, et al. Nature. 2018 Feb 22;554(7693):481-486. doi: 10.1038/nature25453. Epub 2017 Dec 20. Nature. 2018. PMID: 29261642 Free PMC article.
The flexible propeller blades can adopt distinct conformations, and consist of a series of four-transmembrane helical bundles that we term Piezo repeats. Carboxy-terminal domains line the central ion pore, and the channel is closed by constrictions in the cytosol. ...
The flexible propeller blades can adopt distinct conformations, and consist of a series of four-transmembrane helical bundles that we ter …
Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3.
Hirschi M, Herzik MA Jr, Wie J, Suo Y, Borschel WF, Ren D, Lander GC, Lee SY. Hirschi M, et al. Nature. 2017 Oct 19;550(7676):411-414. doi: 10.1038/nature24055. Epub 2017 Oct 11. Nature. 2017. PMID: 29019979 Free PMC article.
Our structure reveals not only the molecular basis of ion conduction but also the unique architecture of TRPMLs, wherein the voltage sensor-like domain is linked to the pore via a cytosolic domain that we term the mucolipin domain. Combined with functional studies, these d …
Our structure reveals not only the molecular basis of ion conduction but also the unique architecture of TRPMLs, wherein the voltage sensor- …