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Prefrontal mechanisms in extinction of conditioned fear.
Quirk GJ, Garcia R, González-Lima F. Quirk GJ, et al. Biol Psychiatry. 2006 Aug 15;60(4):337-43. doi: 10.1016/j.biopsych.2006.03.010. Epub 2006 May 19. Biol Psychiatry. 2006. PMID: 16712801 Review.
Lesions of the basal amygdala block expression of conditioned fear but not extinction.
Anglada-Figueroa D, Quirk GJ. Anglada-Figueroa D, et al. J Neurosci. 2005 Oct 19;25(42):9680-5. doi: 10.1523/JNEUROSCI.2600-05.2005. J Neurosci. 2005. PMID: 16237172 Free PMC article.
Replicating previous studies, we found that rats given electrolytic BA lesions before training acquired conditioned fear normally. They also showed normal long-term retention and extinction of conditioned fear. Unexpectedly, BA lesions made after training completely blocke …
Replicating previous studies, we found that rats given electrolytic BA lesions before training acquired conditioned fear normally. They also …
Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex.
Santini E, Ge H, Ren K, Peña de Ortiz S, Quirk GJ. Santini E, et al. J Neurosci. 2004 Jun 23;24(25):5704-10. doi: 10.1523/JNEUROSCI.0786-04.2004. J Neurosci. 2004. PMID: 15215292 Free PMC article.
Extinction of conditioned fear is thought to form a long-term memory of safety, but the neural mechanisms are poorly understood. ...
Extinction of conditioned fear is thought to form a long-term memory of safety, but the neural mechanisms are poorly understood. ...
Memory for extinction of conditioned fear is long-lasting and persists following spontaneous recovery.
Quirk GJ. Quirk GJ. Learn Mem. 2002 Nov-Dec;9(6):402-7. doi: 10.1101/lm.49602. Learn Mem. 2002. PMID: 12464700 Free PMC article.
These data support the idea that conditioning and extinction of fear are learned by independent systems, each able to retain a long-term memory....
These data support the idea that conditioning and extinction of fear are learned by independent systems, each able to retain a long-term …
Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory.
Santini E, Muller RU, Quirk GJ. Santini E, et al. J Neurosci. 2001 Nov 15;21(22):9009-17. doi: 10.1523/JNEUROSCI.21-22-09009.2001. J Neurosci. 2001. PMID: 11698611 Free PMC article.
This suggests that an NMDA-independent form of plasticity supports short-term extinction memory, but NMDA receptors are required for consolidation processes leading to long-term extinction memory. ...
This suggests that an NMDA-independent form of plasticity supports short-term extinction memory, but NMDA receptors are required for …