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Ceftriaxone, a GLT-1 transporter activator, disrupts hippocampal learning in rats.
Matos-Ocasio F, Hernández-López A, Thompson KJ. Matos-Ocasio F, et al. Pharmacol Biochem Behav. 2014 Jul;122:118-21. doi: 10.1016/j.pbb.2014.03.011. Epub 2014 Mar 18. Pharmacol Biochem Behav. 2014. PMID: 24650590 Free PMC article.
This GLT-1 up-regulation blocks the metabotropic glutamate receptor (mGluR) dependent long-term depression (LTD) at the mossy fiber (MF)-CA3 hippocampal synapse. It also has negative effects on long-term potentiation (LTP). However, the effects of GLT-1 up-regulatio …
This GLT-1 up-regulation blocks the metabotropic glutamate receptor (mGluR) dependent long-term depression (LTD) at the mossy fiber ( …
Factors associated with breast cancer in Puerto Rican women.
Morales L, Alvarez-Garriga C, Matta J, Ortiz C, Vergne Y, Vargas W, Acosta H, Ramírez J, Perez-Mayoral J, Bayona M. Morales L, et al. J Epidemiol Glob Health. 2013 Dec;3(4):205-15. doi: 10.1016/j.jegh.2013.08.003. Epub 2013 Oct 12. J Epidemiol Glob Health. 2013. PMID: 24206792 Free PMC article.
RESULTS: A low DRC level, aging (>61years), family history of BC, and low education level had statistically significant associations with increased BC risk. Endometriosis, full-term pregnancy at an earlier age, higher parity, hysterectomy before age 50, multivitamin and …
RESULTS: A low DRC level, aging (>61years), family history of BC, and low education level had statistically significant associations with …
Apolipoprotein E Allelic Frequency Altered in Women with Early-onset Breast Cancer.
Porrata-Doria T, Matta JL, Acevedo SF. Porrata-Doria T, et al. Breast Cancer (Auckl). 2010 May 24;4:43-8. Breast Cancer (Auckl). 2010. PMID: 20697532 Free PMC article.
We found an increased frequency of apoE4 (odds ratio 2.15) only in early-onset breast cancer survivors, which is similar to the findings of those studies that combined or adjusted for age as well as for an association between apoE4 and decreased tumor size. ApoE is also a potenti …
We found an increased frequency of apoE4 (odds ratio 2.15) only in early-onset breast cancer survivors, which is similar to the findings of …
Systemic propranolol acts centrally to reduce conditioned fear in rats without impairing extinction.
Rodriguez-Romaguera J, Sotres-Bayon F, Mueller D, Quirk GJ. Rodriguez-Romaguera J, et al. Biol Psychiatry. 2009 May 15;65(10):887-92. doi: 10.1016/j.biopsych.2009.01.009. Epub 2009 Feb 26. Biol Psychiatry. 2009. PMID: 19246030 Free PMC article.
Reduced fear with intact extinction suggests a possible use for propranolol in reducing anxiety during extinction-based exposure therapies, without interfering with long-term clinical response....
Reduced fear with intact extinction suggests a possible use for propranolol in reducing anxiety during extinction-based exposure therapies, …
Lesions of the basal amygdala block expression of conditioned fear but not extinction.
Anglada-Figueroa D, Quirk GJ. Anglada-Figueroa D, et al. J Neurosci. 2005 Oct 19;25(42):9680-5. doi: 10.1523/JNEUROSCI.2600-05.2005. J Neurosci. 2005. PMID: 16237172 Free PMC article.
Replicating previous studies, we found that rats given electrolytic BA lesions before training acquired conditioned fear normally. They also showed normal long-term retention and extinction of conditioned fear. Unexpectedly, BA lesions made after training completely blocke …
Replicating previous studies, we found that rats given electrolytic BA lesions before training acquired conditioned fear normally. They also …
Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex.
Santini E, Ge H, Ren K, Peña de Ortiz S, Quirk GJ. Santini E, et al. J Neurosci. 2004 Jun 23;24(25):5704-10. doi: 10.1523/JNEUROSCI.0786-04.2004. J Neurosci. 2004. PMID: 15215292 Free PMC article.
Extinction of conditioned fear is thought to form a long-term memory of safety, but the neural mechanisms are poorly understood. ...
Extinction of conditioned fear is thought to form a long-term memory of safety, but the neural mechanisms are poorly understood. ...
Memory for extinction of conditioned fear is long-lasting and persists following spontaneous recovery.
Quirk GJ. Quirk GJ. Learn Mem. 2002 Nov-Dec;9(6):402-7. doi: 10.1101/lm.49602. Learn Mem. 2002. PMID: 12464700 Free PMC article.
These data support the idea that conditioning and extinction of fear are learned by independent systems, each able to retain a long-term memory....
These data support the idea that conditioning and extinction of fear are learned by independent systems, each able to retain a long-term
Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory.
Santini E, Muller RU, Quirk GJ. Santini E, et al. J Neurosci. 2001 Nov 15;21(22):9009-17. doi: 10.1523/JNEUROSCI.21-22-09009.2001. J Neurosci. 2001. PMID: 11698611 Free PMC article.
This suggests that an NMDA-independent form of plasticity supports short-term extinction memory, but NMDA receptors are required for consolidation processes leading to long-term extinction memory. ...
This suggests that an NMDA-independent form of plasticity supports short-term extinction memory, but NMDA receptors are required for …