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Long-term risk of neoplastic events after childhood growth hormone treatment: a population-based cohort study in Sweden.
Tidblad A, Bottai M, Smedby KE, Albertsson-Wikland K, Sävendahl L. Tidblad A, et al. Among authors: savendahl l. Front Endocrinol (Lausanne). 2024 Mar 5;15:1360139. doi: 10.3389/fendo.2024.1360139. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38505755 Free PMC article.
BACKGROUND: Increased risk of neoplastic events after recombinant human growth hormone (rhGH) treatment in childhood has been an ongoing concern but long-term safety data are limited. METHODS: A nationwide population-based cohort study in Sweden of patients treated with rh …
BACKGROUND: Increased risk of neoplastic events after recombinant human growth hormone (rhGH) treatment in childhood has been an ongoing con …
Safety and Efficacy of Bilateral Epiphysiodesis Surgery to Reduce Final Height in Extremely Tall Adolescents - A Follow-up Study.
Aeppli TR, Benyi E, Wehtje H, Chrysis D, Sävendahl L. Aeppli TR, et al. Among authors: savendahl l. Horm Res Paediatr. 2024 Feb 23. doi: 10.1159/000538016. Online ahead of print. Horm Res Paediatr. 2024. PMID: 38402874
Bilateral epiphysiodesis has emerged as a possible treatment method aiming to reduce final height. However, there is still insufficient data on long-term safety and final height outcome. Therefore, the aim of this study was to assess the efficacy and safety of bilateral ep …
Bilateral epiphysiodesis has emerged as a possible treatment method aiming to reduce final height. However, there is still insufficient data …
Humanin Treatment Protects Against Venetoclax-Induced Bone Growth Retardation in Ex Vivo Cultured Rat Bones.
Velentza L, Wickström M, Kogner P, Ohlsson C, Zaman F, Sävendahl L. Velentza L, et al. Among authors: savendahl l. J Endocr Soc. 2024 Jan 25;8(3):bvae009. doi: 10.1210/jendso/bvae009. eCollection 2024 Jan 16. J Endocr Soc. 2024. PMID: 38328478 Free PMC article.
The study in a neuroblastoma mouse model confirmed a growth-suppressive effect of venetoclax treatment. In this short-term in vivo study, no significant bone growth-rescuing effect could be verified when testing HNG at a single dose. ...
The study in a neuroblastoma mouse model confirmed a growth-suppressive effect of venetoclax treatment. In this short-term in vivo st …
Development of A Minimum Dataset for the Monitoring of Recombinant Human Growth Hormone (rhGH) Therapy Use in Children with Growth Hormone Deficiency (GHD) - A GloBE-Reg Initiative.
Chen SC, Bryce J, Chen M, Charmandari E, Choi JH, Dou X, Gong C, Hamza R, Harvey J, Hoffman AR, Horikawa R, Johannson G, Jorge AAL, Miller BS, Roehrich S, Sävendahl L, Tseretopoulou X, Vitali D, Wajnrajch M, Ahmed SF. Chen SC, et al. Among authors: savendahl l. Horm Res Paediatr. 2023 Sep 13. doi: 10.1159/000533763. Online ahead of print. Horm Res Paediatr. 2023. PMID: 37703843 Free article.
Methods This study was undertaken by the GH Scientific Study Group (SSG) in GloBE-Reg, a new project that has developed a common registry platform that can support long-term safety and effectiveness studies of drugs. Twelve clinical experts from 7 international endocrine o …
Methods This study was undertaken by the GH Scientific Study Group (SSG) in GloBE-Reg, a new project that has developed a common registry pl …
Weekly Somapacitan in GH Deficiency: 4-Year Efficacy, Safety, and Treatment/Disease Burden Results From REAL 3.
Sävendahl L, Battelino T, Højby Rasmussen M, Brod M, Röhrich S, Saenger P, Horikawa R. Sävendahl L, et al. J Clin Endocrinol Metab. 2023 Sep 18;108(10):2569-2578. doi: 10.1210/clinem/dgad183. J Clin Endocrinol Metab. 2023. PMID: 36995872 Free PMC article. Clinical Trial.
OBJECTIVE: This work aimed to assess the efficacy and safety of somapacitan, and associated disease/treatment burden, after 4 years of treatment and 1 year after switching to somapacitan from daily GH. METHODS: This long-term safety extension of a multicenter, controlled p …
OBJECTIVE: This work aimed to assess the efficacy and safety of somapacitan, and associated disease/treatment burden, after 4 years of treat …
Bone health in glucocorticoid-treated childhood acute lymphoblastic leukemia.
Velentza L, Zaman F, Sävendahl L. Velentza L, et al. Among authors: savendahl l. Crit Rev Oncol Hematol. 2021 Dec;168:103492. doi: 10.1016/j.critrevonc.2021.103492. Epub 2021 Oct 13. Crit Rev Oncol Hematol. 2021. PMID: 34655742 Free article. Review.
Glucocorticoids (GCs) are widely used in the treatment of childhood acute lymphoblastic leukemia (ALL), but their long-term use is also associated with bone-related morbidities. Among others, growth deficit, decreased bone mineral density (BMD) and increased fracture rate …
Glucocorticoids (GCs) are widely used in the treatment of childhood acute lymphoblastic leukemia (ALL), but their long-term use is al …
Radial shockwave treatment promotes chondrogenesis in human growth plate and longitudinal bone growth in rabbits.
Ramesh S, Zaman F, Sävendahl L, Madhuri V. Ramesh S, et al. Among authors: savendahl l. Bone. 2022 Jan;154:116186. doi: 10.1016/j.bone.2021.116186. Epub 2021 Sep 11. Bone. 2022. PMID: 34520899 Free article.
Therefore, we investigated if rSWT has similar growth promoting effects on cultured human growth plate fragments and addressed the same in a preclinical in vivo rabbit model by subjecting their growth plates to rSWT. METHODS: Short-term effects of high-energy rSWT were eva …
Therefore, we investigated if rSWT has similar growth promoting effects on cultured human growth plate fragments and addressed the same in a …
Long-Term Safety of Growth Hormone Treatment in Childhood: Two Large Observational Studies: NordiNet IOS and ANSWER.
Sävendahl L, Polak M, Backeljauw P, Blair JC, Miller BS, Rohrer TR, Hokken-Koelega A, Pietropoli A, Kelepouris N, Ross J. Sävendahl L, et al. J Clin Endocrinol Metab. 2021 May 13;106(6):1728-1741. doi: 10.1210/clinem/dgab080. J Clin Endocrinol Metab. 2021. PMID: 33571362 Free PMC article.
CONTEXT: Growth hormone (GH) treatment has a generally good safety profile; however, concerns about increased mortality risk in adulthood have been raised. OBJECTIVE: This work aims to assess the long-term safety of GH treatment in clinical practice. METHODS: Data were col …
CONTEXT: Growth hormone (GH) treatment has a generally good safety profile; however, concerns about increased mortality risk in adulthood ha …
Long-Term Effectiveness and Safety of Childhood Growth Hormone Treatment in Noonan Syndrome.
Rohrer TR, Abuzzahab J, Backeljauw P, Birkegård AC, Blair J, Dahlgren J, Júlíusson PB, Ostrow V, Pietropoli A, Polak M, Romano A, Ross J, Sävendahl L, Miller BS. Rohrer TR, et al. Among authors: savendahl l. Horm Res Paediatr. 2020;93(6):380-395. doi: 10.1159/000512429. Epub 2021 Jan 13. Horm Res Paediatr. 2020. PMID: 33440388 Free article.
INTRODUCTION: Few data exist on long-term growth hormone (GH) treatment in patients with Noonan syndrome (NS). ...
INTRODUCTION: Few data exist on long-term growth hormone (GH) treatment in patients with Noonan syndrome (NS). ...
Association of Childhood Growth Hormone Treatment With Long-term Cardiovascular Morbidity.
Tidblad A, Bottai M, Kieler H, Albertsson-Wikland K, Sävendahl L. Tidblad A, et al. Among authors: savendahl l. JAMA Pediatr. 2021 Feb 1;175(2):e205199. doi: 10.1001/jamapediatrics.2020.5199. Epub 2021 Feb 1. JAMA Pediatr. 2021. PMID: 33346824 Free PMC article.
IMPORTANCE: Concerns about the cardiovascular safety of recombinant human growth hormone (rhGH) treatment in childhood have recently been raised; however, long-term studies are limited. OBJECTIVE: To investigate the long-term risk of overall and severe cardiovascula …
IMPORTANCE: Concerns about the cardiovascular safety of recombinant human growth hormone (rhGH) treatment in childhood have recently been ra …
27 results