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Pre- and Post-Sexual Maturity Liver-specific ERα Knockout Does Not Impact Hepatic Mitochondrial Function.
Fuller KNZ, Allen J, Kumari R, Akakpo JY, Ruebel M, Shankar K, Thyfault JP. Fuller KNZ, et al. Among authors: ruebel m. J Endocr Soc. 2023 Apr 27;7(6):bvad053. doi: 10.1210/jendso/bvad053. eCollection 2023 May 5. J Endocr Soc. 2023. PMID: 37197409 Free PMC article.
We phenotyped the liver health and mitochondrial function of LERKO mice (n = 10-12 per group) on a short-term high-fat diet (HFD), and then tested whether timing of LERKO induction at 2 timepoints (sexually immature: 4 weeks old [n = 11 per group] vs sexually mature: 8-10 …
We phenotyped the liver health and mitochondrial function of LERKO mice (n = 10-12 per group) on a short-term high-fat diet (HFD), an …
Maternal nutritional status modifies heat-associated growth restriction in women with chronic malnutrition.
Shankar K, Ali SA, Ruebel ML, Jessani S, Borengasser SJ, Gilley SP, Jambal P, Yazza DN, Weaver N, Kemp JF, Westcott JL, Hendricks AE, Saleem S, Goldenberg RL, Hambidge KM, Krebs NF. Shankar K, et al. Among authors: ruebel ml. PNAS Nexus. 2023 Jan 27;2(1):pgac309. doi: 10.1093/pnasnexus/pgac309. eCollection 2023 Jan. PNAS Nexus. 2023. PMID: 36744021 Free PMC article.
Multiple linear regression of ambient temperature and neonatal anthropometry at birth (n = 459) showed a negative association between daily maximal temperatures in the first trimester and Z-scores of birth length and head circumference. ...Notably, negative impacts …
Multiple linear regression of ambient temperature and neonatal anthropometry at birth (n = 459) showed a negative association between …
Listening to mother: Long-term maternal effects in mammalian development.
Ruebel ML, Latham KE. Ruebel ML, et al. Mol Reprod Dev. 2020 Apr;87(4):399-408. doi: 10.1002/mrd.23336. Epub 2020 Mar 22. Mol Reprod Dev. 2020. PMID: 32202026 Free PMC article. Review.
This review focuses on the effects of oocyte components on developmental processes that occur after the initial stages of embryogenesis. These include long-term effects on genome function, metabolism, lineage allocation, postnatal progeny health, and even subsequent genera …
This review focuses on the effects of oocyte components on developmental processes that occur after the initial stages of embryogenesis. The …
A New Role for SMCHD1 in Life's Master Switch and Beyond.
Schall PZ, Ruebel ML, Latham KE. Schall PZ, et al. Among authors: ruebel ml. Trends Genet. 2019 Dec;35(12):948-955. doi: 10.1016/j.tig.2019.10.001. Epub 2019 Oct 25. Trends Genet. 2019. PMID: 31668908 Free PMC article. Review.
Recent studies have revealed that SMCHD1 plays an important role as a maternal effect gene that regulates the master switch of life, namely embryonic genome activation, as well as subsequent preimplantation development and term viability. These discoveries mark SMCHD1 as a …
Recent studies have revealed that SMCHD1 plays an important role as a maternal effect gene that regulates the master switch of life, namely …
SMCHD1 terminates the first embryonic genome activation event in mouse two-cell embryos and contributes to a transcriptionally repressive state.
Ruebel ML, Vincent KA, Schall PZ, Wang K, Latham KE. Ruebel ML, et al. Am J Physiol Cell Physiol. 2019 Oct 1;317(4):C655-C664. doi: 10.1152/ajpcell.00116.2019. Epub 2019 Jul 31. Am J Physiol Cell Physiol. 2019. PMID: 31365290 Free PMC article.
We previously reported that structural maintenance of chromosomes flexible hinge domain-containing protein 1 (Smchd1) is expressed at the mRNA and protein levels in mouse oocytes and early embryos and that elimination of Smchd1 expression inhibits inner cell mass formation, blast …
We previously reported that structural maintenance of chromosomes flexible hinge domain-containing protein 1 (Smchd1) is expressed at the mR …
Hepatic steatosis development with four weeks of physical inactivity in previously active, hyperphagic OLETF rats.
Linden MA, Meers GM, Ruebel ML, Jenkins NT, Booth FW, Laughlin MH, Ibdah JA, Thyfault JP, Rector RS. Linden MA, et al. Among authors: ruebel ml. Am J Physiol Regul Integr Comp Physiol. 2013 May 1;304(9):R763-71. doi: 10.1152/ajpregu.00537.2012. Epub 2013 Mar 6. Am J Physiol Regul Integr Comp Physiol. 2013. PMID: 23467323 Free PMC article.
Physical activity-induced prevention of hepatic steatosis is maintained during short-term (7-day) transitions to an inactive state; however, whether these protective effects are present under a longer duration of physical inactivity is largely unknown. ...
Physical activity-induced prevention of hepatic steatosis is maintained during short-term (7-day) transitions to an inactive state; h …
Serum markers of bone turnover are increased by modest weight loss with or without weight-bearing exercise in overweight premenopausal women.
Rector RS, Loethen J, Ruebel M, Thomas TR, Hinton PS. Rector RS, et al. Among authors: ruebel m. Appl Physiol Nutr Metab. 2009 Oct;34(5):933-41. doi: 10.1139/H09-098. Appl Physiol Nutr Metab. 2009. PMID: 19935856
We investigated the impact of weight-bearing and nonweight-bearing exercise on serum markers of bone formation and breakdown during short-term, modest weight loss in overweight premenopausal women. Subjects (n = 36) were assigned to 1 of 3 weight-loss interventions designe …
We investigated the impact of weight-bearing and nonweight-bearing exercise on serum markers of bone formation and breakdown during short- …
Lean body mass and weight-bearing activity in the prediction of bone mineral density in physically active men.
Rector RS, Rogers R, Ruebel M, Widzer MO, Hinton PS. Rector RS, et al. Among authors: ruebel m. J Strength Cond Res. 2009 Mar;23(2):427-35. doi: 10.1519/JSC.0b013e31819420e1. J Strength Cond Res. 2009. PMID: 19197207
The purpose of this study was to determine the effects of long-term running, cycling, and resistance training on whole-body and regional bone mineral density (BMD), adjusting for body weight and composition. ...In conclusion, the results of the present study demonstrate th …
The purpose of this study was to determine the effects of long-term running, cycling, and resistance training on whole-body and regio …