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Page 1
The EXTrauterine Environment for Neonatal Development Supports Normal Intestinal Maturation and Development.
Baumgarten HD, Wright CM, Rossidis AC, Lawrence KM, Kim AG, Mejaddam AY, McGovern PE, Orr MN, Coons BE, Butt Z, Li H, Hwang G, Radu A, Brown LJ, Rubenstein RC, Peranteau WH, Davey M, Heuckeroth RO, Flake AW. Baumgarten HD, et al. Among authors: rubenstein rc. Cell Mol Gastroenterol Hepatol. 2020;10(3):623-637. doi: 10.1016/j.jcmgh.2020.05.006. Epub 2020 May 28. Cell Mol Gastroenterol Hepatol. 2020. PMID: 32474164 Free PMC article.
Our goal was to determine if bowel development occurs normally in EXTEND-supported lambs, with specific emphasis on markers of immaturity associated with NEC. METHODS: We compared terminal ileum from 17 pre-term lambs supported on EXTEND for 2- 4 weeks to bowel from age-ma …
Our goal was to determine if bowel development occurs normally in EXTEND-supported lambs, with specific emphasis on markers of immaturity as …
Elevation of one hour plasma glucose during oral glucose tolerance testing.
Sheikh S, Putt ME, Forde KA, Rubenstein RC, Kelly A. Sheikh S, et al. Among authors: rubenstein rc. Pediatr Pulmonol. 2015 Oct;50(10):963-9. doi: 10.1002/ppul.23237. Epub 2015 Jun 18. Pediatr Pulmonol. 2015. PMID: 26087115 Free PMC article.
OBJECTIVES: In cystic fibrosis (CF) patients, elevations in 1 hr plasma glucose (PG1) during a 75 g oral glucose tolerance test are common, but of unclear long-term clinical relevance. Thus, we examined associations of PG1 with percent-predicted forced expiratory volume in …
OBJECTIVES: In cystic fibrosis (CF) patients, elevations in 1 hr plasma glucose (PG1) during a 75 g oral glucose tolerance test are common, …
Long-term treatment with oral N-acetylcysteine: affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled trial.
Conrad C, Lymp J, Thompson V, Dunn C, Davies Z, Chatfield B, Nichols D, Clancy J, Vender R, Egan ME, Quittell L, Michelson P, Antony V, Spahr J, Rubenstein RC, Moss RB, Herzenberg LA, Goss CH, Tirouvanziam R. Conrad C, et al. Among authors: rubenstein rc. J Cyst Fibros. 2015 Mar;14(2):219-27. doi: 10.1016/j.jcf.2014.08.008. Epub 2014 Sep 13. J Cyst Fibros. 2015. PMID: 25228446 Free article. Clinical Trial.
Evidence of CFTR function in cystic fibrosis after systemic administration of 4-phenylbutyrate.
Zeitlin PL, Diener-West M, Rubenstein RC, Boyle MP, Lee CK, Brass-Ernst L. Zeitlin PL, et al. Among authors: rubenstein rc. Mol Ther. 2002 Jul;6(1):119-26. doi: 10.1006/mthe.2002.0639. Mol Ther. 2002. PMID: 12095312 Free article. Clinical Trial.
A maximum tolerated dose of 20 g was defined based on minimal adverse reactions, the safety profile, and a statistically significant induction of chloride transport that was maximal by day 3. This short-term phase I/II study demonstrates proof of principle that modulation …
A maximum tolerated dose of 20 g was defined based on minimal adverse reactions, the safety profile, and a statistically significant inducti …
Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation.
Clancy JP, Rowe SM, Accurso FJ, Aitken ML, Amin RS, Ashlock MA, Ballmann M, Boyle MP, Bronsveld I, Campbell PW, De Boeck K, Donaldson SH, Dorkin HL, Dunitz JM, Durie PR, Jain M, Leonard A, McCoy KS, Moss RB, Pilewski JM, Rosenbluth DB, Rubenstein RC, Schechter MS, Botfield M, Ordoñez CL, Spencer-Green GT, Vernillet L, Wisseh S, Yen K, Konstan MW. Clancy JP, et al. Among authors: rubenstein rc. Thorax. 2012 Jan;67(1):12-8. doi: 10.1136/thoraxjnl-2011-200393. Epub 2011 Aug 8. Thorax. 2012. PMID: 21825083 Free PMC article. Clinical Trial.
Additional data are needed to determine how improvements detected in CFTR function secondary to VX-809 in the sweat gland relate to those measurable in the respiratory tract and to long-term measures of clinical benefit. CLINICAL TRIAL NUMBER: NCT00865904....
Additional data are needed to determine how improvements detected in CFTR function secondary to VX-809 in the sweat gland relate to those me …