Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

9 results

Filters applied: . Clear all
Page 1
SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans.
Mudd PA, Minervina AA, Pogorelyy MV, Turner JS, Kim W, Kalaidina E, Petersen J, Schmitz AJ, Lei T, Haile A, Kirk AM, Mettelman RC, Crawford JC, Nguyen THO, Rowntree LC, Rosati E, Richards KA, Sant AJ, Klebert MK, Suessen T, Middleton WD; SJTRC Study Team; Wolf J, Teefey SA, O'Halloran JA, Presti RM, Kedzierska K, Rossjohn J, Thomas PG, Ellebedy AH. Mudd PA, et al. Among authors: rossjohn j. Cell. 2022 Feb 17;185(4):603-613.e15. doi: 10.1016/j.cell.2021.12.026. Epub 2021 Dec 23. Cell. 2022. PMID: 35026152 Free PMC article.
Collectively, our results underscore the key role that robust T(FH) cell responses play in establishing long-term immunity by this efficacious human vaccine....
Collectively, our results underscore the key role that robust T(FH) cell responses play in establishing long-term immunity by this ef …
The Diverse Family of MR1-Restricted T Cells.
Gherardin NA, McCluskey J, Rossjohn J, Godfrey DI. Gherardin NA, et al. Among authors: rossjohn j. J Immunol. 2018 Nov 15;201(10):2862-2871. doi: 10.4049/jimmunol.1801091. J Immunol. 2018. PMID: 30397170 Review.
A growing body of literature indicates that MR1-restricted T cells are more diverse than the MAIT term implies. Namely, it is increasingly clear that TCR alpha- and TCR beta-chain diversity within the MR1-restricted repertoire provides a potential mechanism of Ag discrimin …
A growing body of literature indicates that MR1-restricted T cells are more diverse than the MAIT term implies. Namely, it is increas …
Structural and regulatory diversity shape HLA-C protein expression levels.
Kaur G, Gras S, Mobbs JI, Vivian JP, Cortes A, Barber T, Kuttikkatte SB, Jensen LT, Attfield KE, Dendrou CA, Carrington M, McVean G, Purcell AW, Rossjohn J, Fugger L. Kaur G, et al. Among authors: rossjohn j. Nat Commun. 2017 Jun 26;8:15924. doi: 10.1038/ncomms15924. Nat Commun. 2017. PMID: 28649982 Free PMC article.
Together with a phylogenetic analysis, these results highlight the diversity and long-term balancing selection of regulatory factors that modulate HLA-C expression....
Together with a phylogenetic analysis, these results highlight the diversity and long-term balancing selection of regulatory factors …
Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals.
Chen Z, Wang H, D'Souza C, Sun S, Kostenko L, Eckle SB, Meehan BS, Jackson DC, Strugnell RA, Cao H, Wang N, Fairlie DP, Liu L, Godfrey DI, Rossjohn J, McCluskey J, Corbett AJ. Chen Z, et al. Among authors: rossjohn j. Mucosal Immunol. 2017 Jan;10(1):58-68. doi: 10.1038/mi.2016.39. Epub 2016 May 4. Mucosal Immunol. 2017. PMID: 27143301 Free article.
Typhimurium. The MAIT cell response was associated with their long-term accumulation in the lungs, draining lymph nodes and spleen. ...
Typhimurium. The MAIT cell response was associated with their long-term accumulation in the lungs, draining lymph nodes and spleen. . …
Public T cell receptors confer high-avidity CD4 responses to HIV controllers.
Benati D, Galperin M, Lambotte O, Gras S, Lim A, Mukhopadhyay M, Nouël A, Campbell KA, Lemercier B, Claireaux M, Hendou S, Lechat P, de Truchis P, Boufassa F, Rossjohn J, Delfraissy JF, Arenzana-Seisdedos F, Chakrabarti LA. Benati D, et al. Among authors: rossjohn j. J Clin Invest. 2016 Jun 1;126(6):2093-108. doi: 10.1172/JCI83792. Epub 2016 Apr 25. J Clin Invest. 2016. PMID: 27111229 Free PMC article.
Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects.
Gartlan KH, Markey KA, Varelias A, Bunting MD, Koyama M, Kuns RD, Raffelt NC, Olver SD, Lineburg KE, Cheong M, Teal BE, Lor M, Comerford I, Teng MW, Smyth MJ, McCluskey J, Rossjohn J, Stockinger B, Boyle GM, Lane SW, Clouston AD, McColl SR, MacDonald KP, Hill GR. Gartlan KH, et al. Among authors: rossjohn j. Blood. 2015 Sep 24;126(13):1609-20. doi: 10.1182/blood-2015-01-622662. Epub 2015 Jul 23. Blood. 2015. PMID: 26206951 Free article.
Thus, the Tc17 differentiation program during GVHD culminates in a highly plastic, hyperinflammatory, poorly cytolytic effector population, which we term "inflammatory iTc17" (iTc17). Because iTc17 cells mediate GVHD without contributing to GVL, therapeutic inhibition of i …
Thus, the Tc17 differentiation program during GVHD culminates in a highly plastic, hyperinflammatory, poorly cytolytic effector population, …
The molecular bases of δ/αβ T cell-mediated antigen recognition.
Pellicci DG, Uldrich AP, Le Nours J, Ross F, Chabrol E, Eckle SB, de Boer R, Lim RT, McPherson K, Besra G, Howell AR, Moretta L, McCluskey J, Heemskerk MH, Gras S, Rossjohn J, Godfrey DI. Pellicci DG, et al. Among authors: rossjohn j. J Exp Med. 2014 Dec 15;211(13):2599-615. doi: 10.1084/jem.20141764. Epub 2014 Dec 1. J Exp Med. 2014. PMID: 25452463 Free PMC article.
Here we characterize a population of human T cells, which we term delta/alphabeta T cells, expressing TCRs comprised of a TCR-delta variable gene (Vdelta1) fused to joining alpha and constant alpha domains, paired with an array of TCR-beta chains. ...
Here we characterize a population of human T cells, which we term delta/alphabeta T cells, expressing TCRs comprised of a TCR-delta v …
Identification of self-antigen-specific T cells reflecting loss of tolerance in autoimmune disease underpins preventative immunotherapeutic strategies in rheumatoid arthritis.
Law SC, Benham H, Reid HH, Rossjohn J, Thomas R. Law SC, et al. Among authors: rossjohn j. Rheum Dis Clin North Am. 2014 Nov;40(4):735-52. doi: 10.1016/j.rdc.2014.07.015. Epub 2014 Sep 2. Rheum Dis Clin North Am. 2014. PMID: 25437289 Review.
Effective immunotherapies to restore immune tolerance promise greater specificity, lower toxicity, and a longer-term solution to controlling and preventing RA. Design of effective therapies requires a fundamental understanding of the critical immunopathogenetic pathways in …
Effective immunotherapies to restore immune tolerance promise greater specificity, lower toxicity, and a longer-term solution to cont …
EcxAB is a founding member of a new family of metalloprotease AB5 toxins with a hybrid cholera-like B subunit.
Ng NM, Littler DR, Paton AW, Le Nours J, Rossjohn J, Paton JC, Beddoe T. Ng NM, et al. Among authors: rossjohn j. Structure. 2013 Nov 5;21(11):2003-13. doi: 10.1016/j.str.2013.08.024. Epub 2013 Oct 3. Structure. 2013. PMID: 24095060 Free article.
Furthermore, EcxA is distinct from previously characterized proteases and thus founds an AB5-associated metzincin family that we term the toxilysins. EcxAB provides the first observation of conserved B subunit usage across different AB5 toxin families and provides evidence …
Furthermore, EcxA is distinct from previously characterized proteases and thus founds an AB5-associated metzincin family that we term …