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Identification of an Optimized Clinical Development Candidate from Cilagicin, an Antibiotic That Evades Resistance by Dual Polyprenyl Phosphate Binding.
Rosenzweig A, Spotton K, Bhattacharjee A, Morales-Amador A, Brady SF. Rosenzweig A, et al. ACS Infect Dis. 2024 Apr 16. doi: 10.1021/acsinfecdis.4c00018. Online ahead of print. ACS Infect Dis. 2024. PMID: 38626307
Dodecacilagicin exhibits low MICs against clinically relevant pathogens in the presence of serum, retains polyprenyl phosphate binding, and evades resistance development even after long-term antibiotic exposure, making dodecacilagicin an appealing candidate for further the …
Dodecacilagicin exhibits low MICs against clinically relevant pathogens in the presence of serum, retains polyprenyl phosphate binding, and …
Management of Patients With Pancreatic Cancer Using the "Right Track" Model.
Rosenzweig A, Berlin J, Chari S, Kindler H, Matrisian L, Mayoral A, Mills J, Nissen N, Picozzi V, Zelada-Arenas F, Fleming J. Rosenzweig A, et al. Oncologist. 2023 Jul 5;28(7):584-595. doi: 10.1093/oncolo/oyad080. Oncologist. 2023. PMID: 37043728 Free PMC article. Review.
Under the framework of the "Right Track" model-right team, right tests, right treatments, data sharing-PanCAN's position statements can provide supplementary guidance to healthcare professionals for the short- and long-term management of patients with the disease....
Under the framework of the "Right Track" model-right team, right tests, right treatments, data sharing-PanCAN's position statements can prov …
Using Telemedicine to Assess and Manage Psychosis in Neurodegenerative Diseases in Long-Term Care.
Shaughnessy L, Brunton S, Chepke C, Farmer JG, Rosenzweig AS, Grossberg G. Shaughnessy L, et al. Among authors: rosenzweig as. J Am Med Dir Assoc. 2022 Jul;23(7):1145-1152. doi: 10.1016/j.jamda.2021.12.033. Epub 2022 Jan 12. J Am Med Dir Assoc. 2022. PMID: 35032454 Free PMC article.
The coronavirus disease 2019 (COVID-19) epidemic has forced a sudden global implementation of telemedicine strategies, including in long-term care (LTC) facilities where many people with dementia and Parkinson disease (PD) reside. ...
The coronavirus disease 2019 (COVID-19) epidemic has forced a sudden global implementation of telemedicine strategies, including in long- …
Associations of Circulating Extracellular RNAs With Myocardial Remodeling and Heart Failure.
Shah RV, Rong J, Larson MG, Yeri A, Ziegler O, Tanriverdi K, Murthy V, Liu X, Xiao C, Pico AR, Huan T, Levy D, Lewis GD, Rosenzweig A, Vasan RS, Das S, Freedman JE. Shah RV, et al. Among authors: rosenzweig a. JAMA Cardiol. 2018 Sep 1;3(9):871-876. doi: 10.1001/jamacardio.2018.2371. JAMA Cardiol. 2018. PMID: 30090932 Free PMC article.
Of these 12 ex-RNAs, 3 micro RNAs (miR-17, miR-20a, and miR-106b) were associated with a 15% reduction in long-term incident HF per 2-fold increase in circulating level during the follow-up period, after adjustments for age, sex, established HF risk factors, and prevalent …
Of these 12 ex-RNAs, 3 micro RNAs (miR-17, miR-20a, and miR-106b) were associated with a 15% reduction in long-term incident HF per 2 …
Plasma Circulating Extracellular RNAs in Left Ventricular Remodeling Post-Myocardial Infarction.
Danielson KM, Shah R, Yeri A, Liu X, Camacho Garcia F, Silverman M, Tanriverdi K, Das A, Xiao C, Jerosch-Herold M, Heydari B, Abbasi S, Van Keuren-Jensen K, Freedman JE, Wang YE, Rosenzweig A, Kwong RY, Das S. Danielson KM, et al. Among authors: rosenzweig a. EBioMedicine. 2018 Jun;32:172-181. doi: 10.1016/j.ebiom.2018.05.013. Epub 2018 May 18. EBioMedicine. 2018. PMID: 29779700 Free PMC article. Clinical Trial.
Despite substantial declines in mortality following myocardial infarction (MI), subsequent left ventricular remodeling (LVRm) remains a significant long-term complication. Extracellular small non-coding RNAs (exRNAs) have been associated with cardiac inflammation and fibro …
Despite substantial declines in mortality following myocardial infarction (MI), subsequent left ventricular remodeling (LVRm) remains a sign …
The use of antipsychotic medication in long-term care.
Epstein-Lubow G, Rosenzweig A. Epstein-Lubow G, et al. Among authors: rosenzweig a. Med Health R I. 2010 Dec;93(12):372, 377-8. Med Health R I. 2010. PMID: 21214075 Review. No abstract available.
Vascular effects of a low-carbohydrate high-protein diet.
Foo SY, Heller ER, Wykrzykowska J, Sullivan CJ, Manning-Tobin JJ, Moore KJ, Gerszten RE, Rosenzweig A. Foo SY, et al. Among authors: rosenzweig a. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15418-23. doi: 10.1073/pnas.0907995106. Epub 2009 Aug 24. Proc Natl Acad Sci U S A. 2009. PMID: 19706393 Free PMC article.
The cardiovascular complications of obesity have prompted interest in dietary interventions to reduce weight, including low-carbohydrate diets that are generally high in protein and fat. However, little is known about the long-term effects of these diets on vascular health …
The cardiovascular complications of obesity have prompted interest in dietary interventions to reduce weight, including low-carbohydrate die …