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GHK peptide prevents sleep-deprived learning impairment in aging mice.
Rosenfeld M, Nickel K, Ladiges W. Rosenfeld M, et al. Aging Pathobiol Ther. 2023;5(1):33-35. doi: 10.31491/apt.2023.03.109. Epub 2023 Mar 29. Aging Pathobiol Ther. 2023. PMID: 37035833 Free PMC article.
GHK prevented an increase in MCP-1 and nitrotyrosine levels in the hippocampus of sleep-deprived mice suggesting that inflammatory and reactive nitrogen/oxygen species activity could be therapeutic targets for learning impairment associated with short-term sleep deprivatio …
GHK prevented an increase in MCP-1 and nitrotyrosine levels in the hippocampus of sleep-deprived mice suggesting that inflammatory and react …
Systemic Corticosteroids in the Management of Pediatric Cystic Fibrosis Pulmonary Exacerbations.
Davis CS, Faino AV, Onchiri F, Gibson RL, Merjaneh L, Ramsey BW, Rosenfeld M, Cogen JD. Davis CS, et al. Among authors: rosenfeld m. Ann Am Thorac Soc. 2023 Jan;20(1):75-82. doi: 10.1513/AnnalsATS.202203-201OC. Ann Am Thorac Soc. 2023. PMID: 36044723
CF Foundation PEx guidelines note that a short course of systemic corticosteroids may offer benefit without contributing to long-term adverse effects. However, insufficient evidence exists to recommend systemic corticosteroids for PEx treatment. ...
CF Foundation PEx guidelines note that a short course of systemic corticosteroids may offer benefit without contributing to long-term …
Younger Age at Onset Is Associated With Worse Long-term Behavioral Outcomes in Anti-NMDA Receptor Encephalitis.
Yeshokumar A, Gordon-Lipkin E, Arenivas A, Rosenfeld M, Patterson K, Blum R, Banwell B, Venkatesan A, Lancaster E, Panzer J, Probasco J. Yeshokumar A, et al. Among authors: rosenfeld m. Neurol Neuroimmunol Neuroinflamm. 2022 Jul 6;9(5):e200013. doi: 10.1212/NXI.0000000000200013. Print 2022 Sep. Neurol Neuroimmunol Neuroinflamm. 2022. PMID: 35794025 Free PMC article.
It typically presents in adolescence and young adulthood, but little is known about its potential long-term consequences across the lifespan. Adaptive behavior describes an individual's ability to respond and adapt to environmental demands and unanticipated changes in dail …
It typically presents in adolescence and young adulthood, but little is known about its potential long-term consequences across the l …
PROMISE: Working with the CF community to understand emerging clinical and research needs for those treated with highly effective CFTR modulator therapy.
Nichols DP, Donaldson SH, Frederick CA, Freedman SD, Gelfond D, Hoffman LR, Kelly A, Narkewicz MR, Pittman JE, Ratjen F, Sagel SD, Rosenfeld M, Schwarzenberg SJ, Singh PK, Solomon GM, Stalvey MS, Kirby S, VanDalfsen JM, Clancy JP, Rowe SM. Nichols DP, et al. Among authors: rosenfeld m. J Cyst Fibros. 2021 Mar;20(2):205-212. doi: 10.1016/j.jcf.2021.02.003. Epub 2021 Feb 19. J Cyst Fibros. 2021. PMID: 33619012 Free PMC article. Review.
Multiple observational research studies are now being conducted to better understand the impacts of this important therapeutic milestone on long-term outcomes, patient care needs, and future research priorities. ...
Multiple observational research studies are now being conducted to better understand the impacts of this important therapeutic milestone on …
Prophylactic anti-staphylococcal antibiotics for cystic fibrosis.
Rosenfeld M, Rayner O, Smyth AR. Rosenfeld M, et al. Cochrane Database Syst Rev. 2020 Sep 30;9(9):CD001912. doi: 10.1002/14651858.CD001912.pub5. Cochrane Database Syst Rev. 2020. PMID: 32997797 Free PMC article.
Prophylactic antibiotics are prescribed hoping to prevent such infection and lung damage. Antibiotics have adverse effects and long-term use might lead to infection with Pseudomonas aeruginosa. This is an update of a previously published review. ...As the studies reviewed …
Prophylactic antibiotics are prescribed hoping to prevent such infection and lung damage. Antibiotics have adverse effects and long-term …
Clinical features, prognostic factors, and antibody effects in anti-mGluR1 encephalitis.
Spatola M, Petit Pedrol M, Maudes E, Simabukuro M, Muñiz-Castrillo S, Pinto AL, Wandinger KP, Spiegler J, Schramm P, Dutra LA, Iorio R, Kornblum C, Bien CG, Höftberger R, Leypoldt F, Titulaer MJ, Sillevis Smitt P, Honnorat J, Rosenfeld MR, Graus F, Dalmau J. Spatola M, et al. Among authors: rosenfeld mr. Neurology. 2020 Dec 1;95(22):e3012-e3025. doi: 10.1212/WNL.0000000000010854. Epub 2020 Sep 14. Neurology. 2020. PMID: 32928978 Free PMC article.
CONCLUSIONS: Anti-mGluR1 encephalitis manifests as a severe cerebellar syndrome, often resulting in long-term disability and cerebellar atrophy. The antibodies are pathogenic and cause significant decrease of mGluR1 clusters in cultured neurons....
CONCLUSIONS: Anti-mGluR1 encephalitis manifests as a severe cerebellar syndrome, often resulting in long-term disability and cerebell …
The DNA methyltransferase DNMT3A contributes to autophagy long-term memory.
González-Rodríguez P, Cheray M, Füllgrabe J, Salli M, Engskog-Vlachos P, Keane L, Cunha V, Lupa A, Li W, Ma Q, Dreij K, Rosenfeld MG, Joseph B. González-Rodríguez P, et al. Among authors: rosenfeld mg. Autophagy. 2021 May;17(5):1259-1277. doi: 10.1080/15548627.2020.1816664. Epub 2020 Sep 14. Autophagy. 2021. PMID: 32876528 Free PMC article.
In fact, DNA-methylation mediated by de novo DNA methyltransferase DNMT3A of MAP1LC3 loci upon autophagy stimulation leads to the observed long-term decrease of MAP1LC3 isoforms at transcriptional level. Finally, we report that the downregulation of MAP1LC3 expression can …
In fact, DNA-methylation mediated by de novo DNA methyltransferase DNMT3A of MAP1LC3 loci upon autophagy stimulation leads to the observed l …
Palivizumab and Long-term Outcomes in Cystic Fibrosis.
Fink AK, Graff G, Byington CL, Loeffler DR, Rosenfeld M, Saiman L. Fink AK, et al. Among authors: rosenfeld m. Pediatrics. 2019 Jul;144(1):e20183495. doi: 10.1542/peds.2018-3495. Pediatrics. 2019. PMID: 31239289
BACKGROUND: The American Academy of Pediatrics does not recommend routine use of palivizumab prophylaxis for infants with cystic fibrosis (CF) but recommends consideration in infants with clinical evidence of chronic lung disease or nutritional compromise. However, the beneficial …
BACKGROUND: The American Academy of Pediatrics does not recommend routine use of palivizumab prophylaxis for infants with cystic fibrosis (C …
Prophylactic anti-staphylococcal antibiotics for cystic fibrosis.
Smyth AR, Rosenfeld M. Smyth AR, et al. Among authors: rosenfeld m. Cochrane Database Syst Rev. 2017 Apr 18;4(4):CD001912. doi: 10.1002/14651858.CD001912.pub4. Cochrane Database Syst Rev. 2017. PMID: 28417451 Free PMC article. Updated. Review.
Prophylactic antibiotics are prescribed hoping to prevent such infection and lung damage. Antibiotics have adverse effects and long-term use might lead to infection with Pseudomonas aeruginosa. This is an update of a previously published review. ...As the studies reviewed …
Prophylactic antibiotics are prescribed hoping to prevent such infection and lung damage. Antibiotics have adverse effects and long-term …
Antibody-Mediated Inhibition of Tspan12 Ameliorates Vasoproliferative Retinopathy Through Suppression of β-Catenin Signaling.
Bucher F, Zhang D, Aguilar E, Sakimoto S, Diaz-Aguilar S, Rosenfeld M, Zha Z, Zhang H, Friedlander M, Yea K. Bucher F, et al. Among authors: rosenfeld m. Circulation. 2017 Jul 11;136(2):180-195. doi: 10.1161/CIRCULATIONAHA.116.025604. Epub 2017 Mar 29. Circulation. 2017. PMID: 28356444
However, the need for continued treatment, the presence of nonresponders, and the risk of long-term side effects limit the success of existing therapeutic agents. ...Combination therapy with the Tspan12 blocking antibody can be used to reduce anti-vascular endothelial grow …
However, the need for continued treatment, the presence of nonresponders, and the risk of long-term side effects limit the success of …
55 results