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The varying faces of IL-6: From cardiac protection to cardiac failure.
Fontes JA, Rose NR, Čiháková D. Fontes JA, et al. Among authors: rose nr. Cytokine. 2015 Jul;74(1):62-8. doi: 10.1016/j.cyto.2014.12.024. Epub 2015 Jan 31. Cytokine. 2015. PMID: 25649043 Free PMC article. Review.
IL6 becomes elevated in the acute response to host injury and can activate immune cells, direct immune cell trafficking, signal protective responses in local tissue, initial the acute phase response or initiate wound healing. In the short term this proinflammatory response …
IL6 becomes elevated in the acute response to host injury and can activate immune cells, direct immune cell trafficking, signal protective r …
Hashimoto thyroiditis: clinical and diagnostic criteria.
Caturegli P, De Remigis A, Rose NR. Caturegli P, et al. Among authors: rose nr. Autoimmun Rev. 2014 Apr-May;13(4-5):391-7. doi: 10.1016/j.autrev.2014.01.007. Epub 2014 Jan 13. Autoimmun Rev. 2014. PMID: 24434360 Review.
In addition to this classic form, several other clinico-pathologic entities are now included under the term HT: fibrous variant, IgG4-related variant, juvenile form, Hashitoxicosis, and painless thyroiditis (sporadic or post-partum). ...
In addition to this classic form, several other clinico-pathologic entities are now included under the term HT: fibrous variant, IgG4 …
Infection and thyroid autoimmunity: A seroepidemiologic study of TPOaAb.
Wasserman EE, Nelson K, Rose NR, Rhode C, Pillion JP, Seaberg E, Talor MV, Burek L, Eaton W, Duggan A, Yolken RH. Wasserman EE, et al. Among authors: rose nr. Autoimmunity. 2009 Aug;42(5):439-46. doi: 10.1080/08916930902787716. Autoimmunity. 2009. PMID: 19811261
As a result, a solid body of evidence regarding this theoretically intriguing connection remains to be accrued. We studied term sera from 1807 pregnancies in 1591 women for whom IgG status for cytomegalovirus, Epstein-Barr virus, herpes simplex virus type 1, herpes simplex …
As a result, a solid body of evidence regarding this theoretically intriguing connection remains to be accrued. We studied term sera …
Identification of cardiac troponin I sequence motifs leading to heart failure by induction of myocardial inflammation and fibrosis.
Kaya Z, Göser S, Buss SJ, Leuschner F, Ottl R, Li J, Völkers M, Zittrich S, Pfitzer G, Rose NR, Katus HA. Kaya Z, et al. Among authors: rose nr. Circulation. 2008 Nov 11;118(20):2063-72. doi: 10.1161/CIRCULATIONAHA.108.788711. Epub 2008 Oct 27. Circulation. 2008. PMID: 18955666 Free PMC article.
BACKGROUND: Despite the widespread use of cardiac troponins for diagnosis of myocyte injury and risk stratification in acute cardiac disorders, little is known about the long-term effects of the released troponins on cardiac function. Recently, we showed that an autoimmune …
BACKGROUND: Despite the widespread use of cardiac troponins for diagnosis of myocyte injury and risk stratification in acute cardiac disorde …
Cell damage and autoimmunity: a critical appraisal.
Mackay IR, Leskovsek NV, Rose NR. Mackay IR, et al. Among authors: rose nr. J Autoimmun. 2008 Feb-Mar;30(1-2):5-11. doi: 10.1016/j.jaut.2007.11.009. J Autoimmun. 2008. PMID: 18194728 Free PMC article. Review.
Although infection may be associated with increased levels of autoantibodies, most infections and virtually all vaccinations in humans lack well-established links to autoimmune diseases. Further application of well-designed, long-term epidemiologic and population-based stu …
Although infection may be associated with increased levels of autoantibodies, most infections and virtually all vaccinations in humans lack …
Cardiac troponin I but not cardiac troponin T induces severe autoimmune inflammation in the myocardium.
Göser S, Andrassy M, Buss SJ, Leuschner F, Volz CH, Ottl R, Zittrich S, Blaudeck N, Hardt SE, Pfitzer G, Rose NR, Katus HA, Kaya Z. Göser S, et al. Among authors: rose nr. Circulation. 2006 Oct 17;114(16):1693-702. doi: 10.1161/CIRCULATIONAHA.106.635664. Epub 2006 Oct 2. Circulation. 2006. PMID: 17015788
Thus, the cardiac troponins are paramount for disease classification and risk stratification. However, little is known about the long-term effects of the released troponins on cardiac function. METHODS AND RESULTS: In this study we prepared recombinant murine cardiac tropo …
Thus, the cardiac troponins are paramount for disease classification and risk stratification. However, little is known about the long-ter …
Increased thyroidal fat and goitrous hypothyroidism induced by interferon-gamma.
Kimura H, Kimura M, Westra WH, Rose NR, Caturegli P. Kimura H, et al. Among authors: rose nr. Int J Exp Pathol. 2005 Apr;86(2):97-106. doi: 10.1111/j.0959-9673.2005.00418.x. Int J Exp Pathol. 2005. PMID: 15810981 Free PMC article.
We previously reported that transgenic mice expressing IFN-gamma under the control of the thyroglobulin promoter develop primary hypothyroidism. In order to determine the long-term changes induced by IFN-gamma in the thyroid gland, we analysed cross-sectionally 202 mice (9 …
We previously reported that transgenic mice expressing IFN-gamma under the control of the thyroglobulin promoter develop primary hypothyroid …
On the mystique of the immunological self.
Silverstein AM, Rose NR. Silverstein AM, et al. Among authors: rose nr. Immunol Rev. 1997 Oct;159:197-206; discussion 207-18. doi: 10.1111/j.1600-065x.1997.tb01016.x. Immunol Rev. 1997. PMID: 9416512 Review.
With the discovery of tolerance, the concept of immunological surveillance, and especially with the discovery of HLA restriction of T-cell recognition, the term "the immunological self" and the phrase "self-nonself discrimination" have gained wide currency. ...
With the discovery of tolerance, the concept of immunological surveillance, and especially with the discovery of HLA restriction of T-cell r …
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Mason JW, O'Connell JB, Herskowitz A, Rose NR, McManus BM, Billingham ME, Moon TE. Mason JW, et al. Among authors: rose nr. N Engl J Med. 1995 Aug 3;333(5):269-75. doi: 10.1056/NEJM199508033330501. N Engl J Med. 1995. PMID: 7596370 Free article. Clinical Trial.
Ventricular function improved regardless of whether patients received immunosuppressive therapy, but long-term mortality was high. Patients with a vigorous inflammatory response had less severe disease....
Ventricular function improved regardless of whether patients received immunosuppressive therapy, but long-term mortality was high. Pa …
Natural killer cell activity of prostatic cancer patients.
Choe BK, Frost P, Morrison MK, Rose NR. Choe BK, et al. Among authors: rose nr. Cancer Invest. 1987;5(4):285-91. Cancer Invest. 1987. PMID: 2444316
Because of these interassay variations, it is necessary to use standard control subjects during long-term monitoring of the NK activity of the patients....
Because of these interassay variations, it is necessary to use standard control subjects during long-term monitoring of the NK activi …
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