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FoxP3 expression by retinal pigment epithelial cells: transcription factor with potential relevance for the pathology of age-related macular degeneration.
Alfaar AS, Stürzbecher L, Diedrichs-Möhring M, Lam M, Roubeix C, Ritter J, Schumann K, Annamalai B, Pompös IM, Rohrer B, Sennlaub F, Reichhart N, Wildner G, Strauß O. Alfaar AS, et al. Among authors: rohrer b. J Neuroinflammation. 2022 Oct 22;19(1):260. doi: 10.1186/s12974-022-02620-w. J Neuroinflammation. 2022. PMID: 36273134 Free PMC article.
RESULTS: RPE in vivo displayed increased nuclear FoxP3-expression with increases in age and inflammation, long-term exposure of mice to cigarette smoke, or after laser burn injury. ...
RESULTS: RPE in vivo displayed increased nuclear FoxP3-expression with increases in age and inflammation, long-term exposure of mice …
Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye.
Belhaj M, Annamalai B, Parsons N, Shuler A, Potts J, Rohrer B. Belhaj M, et al. Among authors: rohrer b. J Vis Exp. 2020 Mar 30;(157). doi: 10.3791/60162. J Vis Exp. 2020. PMID: 32281978
Encapsulated cells expressing the biologic of choice are becoming a tool for local protein production and release (e.g., via long-term drug delivery). In addition, encapsulation systems utilize permeable materials that allow diffusion of nutrients, waste, and therapeutic f …
Encapsulated cells expressing the biologic of choice are becoming a tool for local protein production and release (e.g., via long-term …
Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion.
Bowers JS, Nelson MH, Majchrzak K, Bailey SR, Rohrer B, Kaiser AD, Atkinson C, Gattinoni L, Paulos CM. Bowers JS, et al. Among authors: rohrer b. JCI Insight. 2017 Mar 9;2(5):e90772. doi: 10.1172/jci.insight.90772. JCI Insight. 2017. PMID: 28289713 Free PMC article.
Adoptive immunotherapy for solid tumors relies on infusing large numbers of T cells to mediate successful antitumor responses in patients. While long-term rapid-expansion protocols (REPs) produce sufficient numbers of CD8(+) T cells for treatment, they also cause decline i …
Adoptive immunotherapy for solid tumors relies on infusing large numbers of T cells to mediate successful antitumor responses in patients. W …
Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation.
Kunchithapautham K, Atkinson C, Rohrer B. Kunchithapautham K, et al. Among authors: rohrer b. J Biol Chem. 2014 May 23;289(21):14534-46. doi: 10.1074/jbc.M114.564674. Epub 2014 Apr 7. J Biol Chem. 2014. PMID: 24711457 Free PMC article.
To examine this relationship further, RPE monolayers were exposed to CSE. Short term smoke exposure resulted in production and release of complement C3, the generation of C3a, oxidative stress, complement activation on the cell membrane, and ER stress. Long term exp …
To examine this relationship further, RPE monolayers were exposed to CSE. Short term smoke exposure resulted in production and releas …
Prolonged SRC kinase activation, a mechanism to turn transient, sublytic complement activation into a sustained pathological condition in retinal pigment epithelium cells.
Rohrer B, Kunchithapautham K, Genewsky A, Strauß O. Rohrer B, et al. Adv Exp Med Biol. 2014;801:221-7. doi: 10.1007/978-1-4614-3209-8_29. Adv Exp Med Biol. 2014. PMID: 24664702
Here, we asked how this transient, sublytic complement activation could trigger long-term pathological changes in RPE cells. The initial activation of the L-type voltage-gated calcium channels was followed by calcium influx and activation of several kinases. ...
Here, we asked how this transient, sublytic complement activation could trigger long-term pathological changes in RPE cells. The init …
Differential effects of rapamycin on rods and cones during light-induced stress in albino mice.
Kunchithapautham K, Coughlin B, Lemasters JJ, Rohrer B. Kunchithapautham K, et al. Among authors: rohrer b. Invest Ophthalmol Vis Sci. 2011 May 5;52(6):2967-75. doi: 10.1167/iovs.10-6278. Invest Ophthalmol Vis Sci. 2011. PMID: 21273550 Free PMC article.
PURPOSE: Autophagy is a lysosomal machinery-dependent process that catabolizes cellular components/organelles and proteins in an autophagic vacuole (AV)-dependent and -independent manner, respectively. Short-term exposure of the retina to bright light results in shortening …
PURPOSE: Autophagy is a lysosomal machinery-dependent process that catabolizes cellular components/organelles and proteins in an autophagic …
Candidate genes for chromosomes 6 and 10 quantitative trait loci for age-related retinal degeneration in mice.
Ogando DG, Dahlquist KD, Alizadeh M, Kunchithapautham K, Li J, Yu N, LaVail MM, Rohrer B, Vollrath D, Danciger M. Ogando DG, et al. Among authors: rohrer b. Mol Vis. 2010 Jun 5;16:1004-18. Mol Vis. 2010. PMID: 20577653 Free PMC article.
While Tnfaip3 was excluded as the QTG for the Chr 10 QTL, Dok1 and Htra2 remain good candidates for the Chr 6 QTL. Finally, the GO term analysis further supports the general hypothesis that oxidative stress is involved in ageRD....
While Tnfaip3 was excluded as the QTG for the Chr 10 QTL, Dok1 and Htra2 remain good candidates for the Chr 6 QTL. Finally, the GO term …
Robot-aided neurorehabilitation: from evidence-based to science-based rehabilitation.
Krebs HI, Volpe BT, Ferraro M, Fasoli S, Palazzolo J, Rohrer B, Edelstein L, Hogan N. Krebs HI, et al. Among authors: rohrer b. Top Stroke Rehabil. 2002 Winter;8(4):54-70. doi: 10.1310/6177-QDJJ-56DU-0NW0. Top Stroke Rehabil. 2002. PMID: 14523730
We will provide evidence that robot-aided training enhances recovery, that this enhanced recovery is sustained in the long term, and that this recovery is not due to a general physiological improvement--in fact, it appears to be limb and muscle group specific. ...
We will provide evidence that robot-aided training enhances recovery, that this enhanced recovery is sustained in the long term, and …
Long-term platinum excretion in patients treated with cisplatin.
Schierl R, Rohrer B, Hohnloser J. Schierl R, et al. Among authors: rohrer b. Cancer Chemother Pharmacol. 1995;36(1):75-8. doi: 10.1007/BF00685736. Cancer Chemother Pharmacol. 1995. PMID: 7720180
The purpose of this study was to determine long-term renal platinum excretion after chemotherapy with cisplatin. ...Urinary platinum concentrations in our patients ranged between 0.74 and 77.24 micrograms/g creatinine, depending on the total delivered dose and follow-up pe …
The purpose of this study was to determine long-term renal platinum excretion after chemotherapy with cisplatin. ...Urinary platinum …