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NCOR1 Sustains Colorectal Cancer Cell Growth and Protects against Cellular Senescence.
St-Jean S, De Castro AC, Lecours M, Jones C, Rivard N, Rodier F, Perreault N, Boudreau F. St-Jean S, et al. Among authors: rodier f. Cancers (Basel). 2021 Sep 1;13(17):4414. doi: 10.3390/cancers13174414. Cancers (Basel). 2021. PMID: 34503224 Free PMC article.
The acquisition of a pro-metastasis signature in the absence of NCOR1 could indicate long-term potential adverse consequences of colon-cancer-induced senescence....
The acquisition of a pro-metastasis signature in the absence of NCOR1 could indicate long-term potential adverse consequences of colo …
Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia.
Morel S, Léveillé P, Samoilenko M, Franco A, England J, Malaquin N, Tu V, Cardin GB, Drouin S, Rodier F, Lippé S, Krajinovic M, Laverdière C, Sinnett D, Lefebvre G, Levy E, Marcil V. Morel S, et al. Among authors: rodier f. Sci Rep. 2020 Dec 9;10(1):21507. doi: 10.1038/s41598-020-78493-x. Sci Rep. 2020. PMID: 33299020 Free PMC article.
Identification of biomarkers and biological mechanisms could open new avenues for prevention strategies to minimize the long-term sequelae, improve follow-up and optimize the quality of life of this high-risk population....
Identification of biomarkers and biological mechanisms could open new avenues for prevention strategies to minimize the long-term seq …
Autophagy drives fibroblast senescence through MTORC2 regulation.
Bernard M, Yang B, Migneault F, Turgeon J, Dieudé M, Olivier MA, Cardin GB, El-Diwany M, Underwood K, Rodier F, Hébert MJ. Bernard M, et al. Among authors: rodier f. Autophagy. 2020 Nov;16(11):2004-2016. doi: 10.1080/15548627.2020.1713640. Epub 2020 Jan 13. Autophagy. 2020. PMID: 31931659 Free PMC article.
Sustained macroautophagy/autophagy favors the differentiation of fibroblasts into myofibroblasts. Cellular senescence, another means of responding to long-term cellular stress, has also been linked to myofibroblast differentiation and fibrosis. ...
Sustained macroautophagy/autophagy favors the differentiation of fibroblasts into myofibroblasts. Cellular senescence, another means of resp …
ATM suppresses SATB1-induced malignant progression in breast epithelial cells.
Ordinario E, Han HJ, Furuta S, Heiser LM, Jakkula LR, Rodier F, Spellman PT, Campisi J, Gray JW, Bissell MJ, Kohwi Y, Kohwi-Shigematsu T. Ordinario E, et al. Among authors: rodier f. PLoS One. 2012;7(12):e51786. doi: 10.1371/journal.pone.0051786. Epub 2012 Dec 10. PLoS One. 2012. PMID: 23251624 Free PMC article.
We found the reason for reduction to be phenotypic drift due to long-term cultivation of MCF10A. ATM knockdown in MCF10A-2 and two other non-malignant breast epithelial cell lines, 184A1 and 184B4, enabled SATB1 to induce malignant phenotypes similar to that observed for M …
We found the reason for reduction to be phenotypic drift due to long-term cultivation of MCF10A. ATM knockdown in MCF10A-2 and two ot …
DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion.
Rodier F, Muñoz DP, Teachenor R, Chu V, Le O, Bhaumik D, Coppé JP, Campeau E, Beauséjour CM, Kim SH, Davalos AR, Campisi J. Rodier F, et al. J Cell Sci. 2011 Jan 1;124(Pt 1):68-81. doi: 10.1242/jcs.071340. Epub 2010 Nov 30. J Cell Sci. 2011. PMID: 21118958 Free PMC article.
To understand how persistent damage foci differ from transient foci that mark repairable DNA lesions, we identify sequential events that differentiate transient foci from persistent foci, which we term 'DNA segments with chromatin alterations reinforcing senescence' (DNA-S …
To understand how persistent damage foci differ from transient foci that mark repairable DNA lesions, we identify sequential events that dif …
p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cells.
Bazarov AV, Van Sluis M, Hines WC, Bassett E, Beliveau A, Campeau E, Mukhopadhyay R, Lee WJ, Melodyev S, Zaslavsky Y, Lee L, Rodier F, Chicas A, Lowe SW, Benhattar J, Ren B, Campisi J, Yaswen P. Bazarov AV, et al. Among authors: rodier f. Aging Cell. 2010 Oct;9(5):736-46. doi: 10.1111/j.1474-9726.2010.00599.x. Epub 2010 Jul 14. Aging Cell. 2010. PMID: 20569236 Free PMC article.
We show that transient expression of p16 stably represses the hTERT gene, encoding the catalytic subunit of telomerase, in both normal and malignant breast epithelial cells. Short-term p16 expression increases the amount of histone H3 trimethylated on lysine 27 (H3K27) bou …
We show that transient expression of p16 stably represses the hTERT gene, encoding the catalytic subunit of telomerase, in both normal and m …
Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status.
Le ON, Rodier F, Fontaine F, Coppe JP, Campisi J, DeGregori J, Laverdière C, Kokta V, Haddad E, Beauséjour CM. Le ON, et al. Among authors: rodier f. Aging Cell. 2010 Jun;9(3):398-409. doi: 10.1111/j.1474-9726.2010.00567.x. Epub 2010 Mar 13. Aging Cell. 2010. PMID: 20331441 Free PMC article.
We hypothesized that IR-induced senescence markers could persist long-term in vivo, possibly contributing to the permanent reduction in tissue functionality. ...Together, our results provide compelling evidence that exposure to IR induces long-term expression of sen …
We hypothesized that IR-induced senescence markers could persist long-term in vivo, possibly contributing to the permanent reduction …