p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cells.
Bazarov AV, Van Sluis M, Hines WC, Bassett E, Beliveau A, Campeau E, Mukhopadhyay R, Lee WJ, Melodyev S, Zaslavsky Y, Lee L, Rodier F, Chicas A, Lowe SW, Benhattar J, Ren B, Campisi J, Yaswen P.
Bazarov AV, et al. Among authors: rodier f.
Aging Cell. 2010 Oct;9(5):736-46. doi: 10.1111/j.1474-9726.2010.00599.x. Epub 2010 Jul 14.
Aging Cell. 2010.
PMID: 20569236
Free PMC article.
We show that transient expression of p16 stably represses the hTERT gene, encoding the catalytic subunit of telomerase, in both normal and malignant breast epithelial cells. Short-term p16 expression increases the amount of histone H3 trimethylated on lysine 27 (H3K27) bou …
We show that transient expression of p16 stably represses the hTERT gene, encoding the catalytic subunit of telomerase, in both normal and m …