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Newborn screening alone insufficient to improve pulmonary outcomes for cystic fibrosis.
Barreda CB, Farrell PM, Laxova A, Eickhoff JC, Braun AT, Coller RJ, Rock MJ. Barreda CB, et al. Among authors: rock mj. J Cyst Fibros. 2021 May;20(3):492-498. doi: 10.1016/j.jcf.2020.06.002. Epub 2020 Jun 13. J Cyst Fibros. 2021. PMID: 32546430 Free PMC article.
Because the evaluations of these subjects by protocol ended in 2012, our objective was to assess long-term pulmonary and mortality outcomes. METHODS: Retrospective analysis of the RCT cohort utilized longitudinal outcome measures obtained from the Cystic Fibrosis Foundatio …
Because the evaluations of these subjects by protocol ended in 2012, our objective was to assess long-term pulmonary and mortality ou …
Changes in visitor profiles and activity patterns following dog supportive modifications to parks: A natural experiment on the health impact of an urban policy.
McCormack GR, Graham TM, Swanson K, Massolo A, Rock MJ. McCormack GR, et al. Among authors: rock mj. SSM Popul Health. 2016 Apr 22;2:237-243. doi: 10.1016/j.ssmph.2016.03.002. eCollection 2016 Dec. SSM Popul Health. 2016. PMID: 29349143 Free PMC article.
Accommodating off-leash dogs in parks has the potential to modify activities undertaken inside parks as well as the profile of visitors, but may not increase park visits among dog-walkers in the short term. Recreation, park, and urban planners and policy-makers need to con …
Accommodating off-leash dogs in parks has the potential to modify activities undertaken inside parks as well as the profile of visitors, but …
Long-term follow-up of cystic fibrosis newborn screening: psychosocial functioning of adolescents and young adults.
Tluczek A, Laxova A, Grieve A, Heun A, Brown RL, Rock MJ, Gershan WM, Farrell PM. Tluczek A, et al. Among authors: rock mj. J Cyst Fibros. 2014 Mar;13(2):227-34. doi: 10.1016/j.jcf.2013.10.001. Epub 2013 Oct 21. J Cyst Fibros. 2014. PMID: 24157354 Free PMC article.
BACKGROUND: Long-term psychosocial outcomes of cystic fibrosis (CF) patients diagnosed through newborn screening remain unknown. ...
BACKGROUND: Long-term psychosocial outcomes of cystic fibrosis (CF) patients diagnosed through newborn screening remain unknown. ...
Cystic Fibrosis Foundation practice guidelines for the management of infants with cystic fibrosis transmembrane conductance regulator-related metabolic syndrome during the first two years of life and beyond.
Cystic Fibrosis Foundation; Borowitz D, Parad RB, Sharp JK, Sabadosa KA, Robinson KA, Rock MJ, Farrell PM, Sontag MK, Rosenfeld M, Davis SD, Marshall BC, Accurso FJ. Cystic Fibrosis Foundation, et al. Among authors: rock mj. J Pediatr. 2009 Dec;155(6 Suppl):S106-16. doi: 10.1016/j.jpeds.2009.09.003. J Pediatr. 2009. PMID: 19914443 Free PMC article.
Mutations in the CFTR gene can cause CF, but not all CFTR mutations are disease-causing. The term CFTR-related metabolic syndrome (CRMS) is proposed to describe infants identified by hypertrypsinogenemia on NBS who have sweat chloride values <60 mmol/L and up to 2 CFTR …
Mutations in the CFTR gene can cause CF, but not all CFTR mutations are disease-causing. The term CFTR-related metabolic syndrome (CR …
Evidence on improved outcomes with early diagnosis of cystic fibrosis through neonatal screening: enough is enough!
Farrell PM, Lai HJ, Li Z, Kosorok MR, Laxova A, Green CG, Collins J, Hoffman G, Laessig R, Rock MJ, Splaingard ML. Farrell PM, et al. Among authors: rock mj. J Pediatr. 2005 Sep;147(3 Suppl):S30-6. doi: 10.1016/j.jpeds.2005.08.012. J Pediatr. 2005. PMID: 16202779 Clinical Trial.
Follow-up evaluation for 16 years showed that height and weight differences persisted long term. Although screened patients had better chest x-ray scores at diagnosis, our trial suggests that the effects of confounders such as Pseudomonas aeruginosa infections led to deter …
Follow-up evaluation for 16 years showed that height and weight differences persisted long term. Although screened patients had bette …
Respiratory infections with Pseudomonas aeruginosa in children with cystic fibrosis: early detection by serology and assessment of risk factors.
West SE, Zeng L, Lee BL, Kosorok MR, Laxova A, Rock MJ, Splaingard MJ, Farrell PM. West SE, et al. Among authors: rock mj. JAMA. 2002 Jun 12;287(22):2958-67. doi: 10.1001/jama.287.22.2958. JAMA. 2002. PMID: 12052125
Once P aeruginosa infection is established, eradication may be impossible, and progressive lung disease often aggravates morbidity and mortality risks. The ability to diagnose CF by genetic testing at birth makes it possible to determine the temporal sequence of events tha …
Once P aeruginosa infection is established, eradication may be impossible, and progressive lung disease often aggravates morbidity and morta …
Aerosol delivery and safety of recombinant human deoxyribonuclease in young children with cystic fibrosis: a bronchoscopic study. Pulmozyme Pediatric Broncoscopy Study Group.
Wagener JS, Rock MJ, McCubbin MM, Hamilton SD, Johnson CA, Ahrens RC. Wagener JS, et al. Among authors: rock mj. J Pediatr. 1998 Oct;133(4):486-91. doi: 10.1016/s0022-3476(98)70055-1. J Pediatr. 1998. PMID: 9787685 Clinical Trial.
The purpose of this study was to assess the delivery to the lungs and the short-term safety of recombinant human deoxyribonuclease (rhDNase, Pulmozyme) in children with cystic fibrosis younger than 5 years of age compared with older children. ...During this time adverse ev …
The purpose of this study was to assess the delivery to the lungs and the short-term safety of recombinant human deoxyribonuclease (r …
Effects of long-term increases in plasma ANP on angiotensin II-induced hypertension.
Granger JP, Blaine EH, Stacy DL, La Rock MJ. Granger JP, et al. Among authors: la rock mj. Am J Physiol. 1990 May;258(5 Pt 2):H1427-31. doi: 10.1152/ajpheart.1990.258.5.H1427. Am J Physiol. 1990. PMID: 2140020
These data indicate that long-term increases in circulating levels of ANP have minimal chronic hypotensive effects in dogs with ANG II hypertension. In addition, the results from this study suggest that physiological increases in plasma ANP do not exhibit long-term …
These data indicate that long-term increases in circulating levels of ANP have minimal chronic hypotensive effects in dogs with ANG I …
Use of ketamine in asthmatic children to treat respiratory failure refractory to conventional therapy.
Rock MJ, Reyes de la Rocha S, L'Hommedieu CS, Truemper E. Rock MJ, et al. Crit Care Med. 1986 May;14(5):514-6. doi: 10.1097/00003246-198605000-00019. Crit Care Med. 1986. PMID: 3698618
Except for increased secretions during the infusion, our patients showed no immediate or long-term sequelae from ketamine therapy. However, ketamine should only be used for asthmatics whose respiratory failure does not respond to conventional management and mechanical vent …
Except for increased secretions during the infusion, our patients showed no immediate or long-term sequelae from ketamine therapy. Ho …