NGF steers microglia toward a neuroprotective phenotype.
Rizzi C, Tiberi A, Giustizieri M, Marrone MC, Gobbo F, Carucci NM, Meli G, Arisi I, D'Onofrio M, Marinelli S, Capsoni S, Cattaneo A.
Rizzi C, et al.
Glia. 2018 Jul;66(7):1395-1416. doi: 10.1002/glia.23312. Epub 2018 Feb 23.
Glia. 2018.
PMID: 29473218
Free PMC article.
Moreover, by acting specifically on microglia, NGF protects neurons from the Abeta-induced loss of dendritic spines and inhibition of long term potentiation. Finally, in an ex-vivo setup of acute brain slices, we observed a similar increase in Abeta engulfment by microglia …
Moreover, by acting specifically on microglia, NGF protects neurons from the Abeta-induced loss of dendritic spines and inhibition of long …