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The connexin 43 carboxyl terminal mimetic peptide αCT1 prompts differentiation of a collagen scar matrix in humans resembling unwounded skin.
Montgomery J, Richardson WJ, Marsh S, Rhett JM, Bustos F, Degen K, Ghatnekar GS, Grek CL, Jourdan LJ, Holmes JW, Gourdie RG. Montgomery J, et al. Among authors: rhett jm. FASEB J. 2021 Aug;35(8):e21762. doi: 10.1096/fj.202001881R. FASEB J. 2021. PMID: 34246197 Free PMC article. Clinical Trial.
In conclusion, alphaCT1 prompts decreased directionality of fibroblast movement and the generation of a 3D collagen matrix postwounding that is similar to unwounded skin-changes that correlate with long-term improvement in scar appearance....
In conclusion, alphaCT1 prompts decreased directionality of fibroblast movement and the generation of a 3D collagen matrix postwounding that …
Connexin-Based Therapeutics and Tissue Engineering Approaches to the Amelioration of Chronic Pancreatitis and Type I Diabetes: Construction and Characterization of a Novel Prevascularized Bioartificial Pancreas.
Rhett JM, Wang H, Bainbridge H, Song L, Yost MJ. Rhett JM, et al. J Diabetes Res. 2016;2016:7262680. doi: 10.1155/2016/7262680. Epub 2015 Dec 14. J Diabetes Res. 2016. PMID: 26788521 Free PMC article.
These results suggest that the prevascularized bioartificial pancreas is potentially a tool for improving long-term islet cell survival in vivo....
These results suggest that the prevascularized bioartificial pancreas is potentially a tool for improving long-term islet cell surviv …
Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1.
Rhett JM, Jourdan J, Gourdie RG. Rhett JM, et al. Mol Biol Cell. 2011 May;22(9):1516-28. doi: 10.1091/mbc.E10-06-0548. Epub 2011 Mar 16. Mol Biol Cell. 2011. PMID: 21411628 Free PMC article.
Immunoprecipitation and Duolink protein-protein interaction assays indicated that inhibition targets ZO-1 binding with Cx43 in GJs as well as connexons in an adjacent domain that we term the "perinexus." Consistent with GJ size increases being matched by decreases in conne …
Immunoprecipitation and Duolink protein-protein interaction assays indicated that inhibition targets ZO-1 binding with Cx43 in GJs as well a …