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The connexin 43 carboxyl terminal mimetic peptide αCT1 prompts differentiation of a collagen scar matrix in humans resembling unwounded skin.
FASEB J. 2021 Aug;35(8):e21762. doi: 10.1096/fj.202001881R.
FASEB J. 2021.
PMID: 34246197
Free PMC article.
Clinical Trial.
In conclusion, alphaCT1 prompts decreased directionality of fibroblast movement and the generation of a 3D collagen matrix postwounding that is similar to unwounded skin-changes that correlate with long-term improvement in scar appearance....
In conclusion, alphaCT1 prompts decreased directionality of fibroblast movement and the generation of a 3D collagen matrix postwounding that …
Connexin-Based Therapeutics and Tissue Engineering Approaches to the Amelioration of Chronic Pancreatitis and Type I Diabetes: Construction and Characterization of a Novel Prevascularized Bioartificial Pancreas.
Rhett JM, Wang H, Bainbridge H, Song L, Yost MJ.
Rhett JM, et al.
J Diabetes Res. 2016;2016:7262680. doi: 10.1155/2016/7262680. Epub 2015 Dec 14.
J Diabetes Res. 2016.
PMID: 26788521
Free PMC article.
These results suggest that the prevascularized bioartificial pancreas is potentially a tool for improving long-term islet cell survival in vivo....
These results suggest that the prevascularized bioartificial pancreas is potentially a tool for improving long-term islet cell surviv …
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Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1.
Rhett JM, Jourdan J, Gourdie RG.
Rhett JM, et al.
Mol Biol Cell. 2011 May;22(9):1516-28. doi: 10.1091/mbc.E10-06-0548. Epub 2011 Mar 16.
Mol Biol Cell. 2011.
PMID: 21411628
Free PMC article.
Immunoprecipitation and Duolink protein-protein interaction assays indicated that inhibition targets ZO-1 binding with Cx43 in GJs as well as connexons in an adjacent domain that we term the "perinexus." Consistent with GJ size increases being matched by decreases in conne …
Immunoprecipitation and Duolink protein-protein interaction assays indicated that inhibition targets ZO-1 binding with Cx43 in GJs as well a …
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