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Non-synonymous, synonymous, and non-coding nucleotide variants contribute to recurrently altered biological processes during retinoblastoma progression.
Stachelek K, Harutyunyan N, Lee S, Beck A, Kim J, Xu L, Berry JL, Nagiel A, Reynolds CP, Murphree AL, Lee TC, Aparicio JG, Cobrinik D. Stachelek K, et al. Among authors: reynolds cp. Genes Chromosomes Cancer. 2023 May;62(5):275-289. doi: 10.1002/gcc.23120. Epub 2023 Jan 5. Genes Chromosomes Cancer. 2023. PMID: 36550020 Free PMC article.
Importantly, non-coding and synonymous variants increased the enrichment significance of each over-represented biological process term. To assess the effects of such mutations, we examined the consequences of a 3' UTR variant of PCGF3 (a BCOR-binding component of Polycomb …
Importantly, non-coding and synonymous variants increased the enrichment significance of each over-represented biological process term …
Pharmacokinetic modeling of an induction regimen for in vivo combined testing of novel drugs against pediatric acute lymphoblastic leukemia xenografts.
Szymanska B, Wilczynska-Kalak U, Kang MH, Liem NL, Carol H, Boehm I, Groepper D, Reynolds CP, Stewart CF, Lock RB. Szymanska B, et al. Among authors: reynolds cp. PLoS One. 2012;7(3):e33894. doi: 10.1371/journal.pone.0033894. Epub 2012 Mar 29. PLoS One. 2012. PMID: 22479469 Free PMC article.
The median progression delay of xenografts derived from long-term surviving patients was 2-fold greater than that of xenografts derived from patients who died of their disease. ...
The median progression delay of xenografts derived from long-term surviving patients was 2-fold greater than that of xenografts deriv …
Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children's oncology group study.
Matthay KK, Reynolds CP, Seeger RC, Shimada H, Adkins ES, Haas-Kogan D, Gerbing RB, London WB, Villablanca JG. Matthay KK, et al. Among authors: reynolds cp. J Clin Oncol. 2009 Mar 1;27(7):1007-13. doi: 10.1200/JCO.2007.13.8925. Epub 2009 Jan 26. J Clin Oncol. 2009. PMID: 19171716 Free PMC article. Clinical Trial.
PURPOSE We assessed the long-term outcome of patients enrolled on CCG-3891, a high-risk neuroblastoma study in which patients were randomly assigned to undergo autologous purged bone marrow transplantation (ABMT) or to receive chemotherapy, and subsequent treatment with 13 …
PURPOSE We assessed the long-term outcome of patients enrolled on CCG-3891, a high-risk neuroblastoma study in which patients were ra …
Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma.
Song L, Ara T, Wu HW, Woo CW, Reynolds CP, Seeger RC, DeClerck YA, Thiele CJ, Sposto R, Metelitsa LS. Song L, et al. Among authors: reynolds cp. J Clin Invest. 2007 Sep;117(9):2702-12. doi: 10.1172/JCI30751. J Clin Invest. 2007. PMID: 17710228 Free PMC article.
We and others have previously demonstrated positive associations between NKT cell presence in primary tumors and long-term survival in distinct human cancers. However, the mechanism by which aggressive tumors avoid infiltration with NKT and other T cells remains poorly und …
We and others have previously demonstrated positive associations between NKT cell presence in primary tumors and long-term survival i …
A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations.
Frgala T, Kalous O, Proffitt RT, Reynolds CP. Frgala T, et al. Among authors: reynolds cp. Mol Cancer Ther. 2007 Mar;6(3):886-97. doi: 10.1158/1535-7163.MCT-04-0331. Mol Cancer Ther. 2007. PMID: 17363483
Cytotoxicity of deferoxamine for neuroblastoma cell lines measured by the DIMSCAN assay achieved dose-response curves similar to data obtained by manual trypan blue counts or colony formation in soft agar but with a wider dynamic range. Long-term cultures documented the cl …
Cytotoxicity of deferoxamine for neuroblastoma cell lines measured by the DIMSCAN assay achieved dose-response curves similar to data obtain …
Bone marrow transplantation for poor prognosis neuroblastoma.
Seeger RC, Moss TJ, Feig SA, Lenarsky C, Selch M, Ramsay N, Harris R, Wells J, Sather H, Reynolds CP. Seeger RC, et al. Among authors: reynolds cp. Prog Clin Biol Res. 1988;271:203-13. Prog Clin Biol Res. 1988. PMID: 3043448
., VAMP-TBI), if given relatively soon after diagnosis and before development of progressive disease, improves long-term survival for patients with advanced neuroblastoma. Although this particular therapy is not useful for those who already have developed progressive disea …
., VAMP-TBI), if given relatively soon after diagnosis and before development of progressive disease, improves long-term survival for …