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Revisiting the outcome of adult wild-type Htt inactivation in the context of HTT-lowering strategies for Huntington's disease.
Regio S, Vachey G, Goñi E, Duarte F, Rybarikova M, Sipion M, Rey M, Huarte M, Déglon N. Regio S, et al. Among authors: rey m. Brain Commun. 2023 Dec 7;5(6):fcad344. doi: 10.1093/braincomms/fcad344. eCollection 2023. Brain Commun. 2023. PMID: 38116140 Free PMC article.
Here, we used the adeno-associated delivery system commonly used in CNS gene therapy programmes and the self-inactivating KamiCas9 gene-editing system to investigate the long-term consequences of wild-type mouse huntingtin inactivation in adult neurons and, thus, the feasi …
Here, we used the adeno-associated delivery system commonly used in CNS gene therapy programmes and the self-inactivating KamiCas9 gene-edit …
A first draft genome of holm oak (Quercus ilex subsp. ballota), the most representative species of the Mediterranean forest and the Spanish agrosylvopastoral ecosystem "dehesa".
Rey MD, Labella-Ortega M, Guerrero-Sánchez VM, Carleial R, Castillejo MÁ, Ruggieri V, Jorrín-Novo JV. Rey MD, et al. Front Mol Biosci. 2023 Oct 12;10:1242943. doi: 10.3389/fmolb.2023.1242943. eCollection 2023. Front Mol Biosci. 2023. PMID: 37905231 Free PMC article.
However, the holm oak and its related ecosystems are threatened by different factors, with oak decline syndrome and climate change being the most worrying in the short and medium term. Breeding programs informed by the selection of elite genotypes seem to be the most plaus …
However, the holm oak and its related ecosystems are threatened by different factors, with oak decline syndrome and climate change being the …
Interactions between interfaces dictate stimuli-responsive emulsion behaviour.
Rey M, Kolker J, Richards JA, Malhotra I, Glen TS, Li NYD, Laidlaw FHJ, Renggli D, Vermant J, Schofield AB, Fujii S, Löwen H, Clegg PS. Rey M, et al. Nat Commun. 2023 Oct 23;14(1):6723. doi: 10.1038/s41467-023-42379-z. Nat Commun. 2023. PMID: 37872193 Free PMC article.
Stimuli-responsive emulsions offer a dual advantage, combining long-term storage with controlled release triggered by external cues such as pH or temperature changes. ...The colloidal properties of the microgels provide the foundation for the long-term stability of …
Stimuli-responsive emulsions offer a dual advantage, combining long-term storage with controlled release triggered by external cues s …
Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery : An International Randomized Controlled Trial.
Marcucci M, Painter TW, Conen D, Lomivorotov V, Sessler DI, Chan MTV, Borges FK, Leslie K, Duceppe E, Martínez-Zapata MJ, Wang CY, Xavier D, Ofori SN, Wang MK, Efremov S, Landoni G, Kleinlugtenbelt YV, Szczeklik W, Schmartz D, Garg AX, Short TG, Wittmann M, Meyhoff CS, Amir M, Torres D, Patel A, Ruetzler K, Parlow JL, Tandon V, Fleischmann E, Polanczyk CA, Lamy A, Jayaram R, Astrakov SV, Wu WKK, Cheong CC, Ayad S, Kirov M, de Nadal M, Likhvantsev VV, Paniagua P, Aguado HJ, Maheshwari K, Whitlock RP, McGillion MH, Vincent J, Copland I, Balasubramanian K, Biccard BM, Srinathan S, Ismoilov S, Pettit S, Stillo D, Kurz A, Belley-Côté EP, Spence J, McIntyre WF, Bangdiwala SI, Guyatt G, Yusuf S, Devereaux PJ; POISE-3 Trial Investigators and Study Groups. Marcucci M, et al. Ann Intern Med. 2023 May;176(5):605-614. doi: 10.7326/M22-3157. Epub 2023 Apr 25. Ann Intern Med. 2023. PMID: 37094336 Clinical Trial.
PATIENTS: 7490 patients having noncardiac surgery who were at risk for vascular complications and were receiving 1 or more long-term antihypertensive medications. INTERVENTION: In the hypotension-avoidance strategy group, the intraoperative mean arterial pressure target wa …
PATIENTS: 7490 patients having noncardiac surgery who were at risk for vascular complications and were receiving 1 or more long-term …
Long-Term Memory Function Impairments following Sucrose Exposure in Juvenile versus Adult Rats.
Coirini H, Rey M, Gonzalez Deniselle MC, Kruse MS. Coirini H, et al. Among authors: rey m. Biomedicines. 2022 Oct 27;10(11):2723. doi: 10.3390/biomedicines10112723. Biomedicines. 2022. PMID: 36359243 Free PMC article.
Here, we evaluated whether high cognitive function is also affected by studying early sucrose consumption in object recognition memory (NOR). Male Sprague Dawley rats were tested for short-term, long-term, and consolidated NOR after 25 days of unlimited sucrose acce …
Here, we evaluated whether high cognitive function is also affected by studying early sucrose consumption in object recognition memory (NOR) …
Long-Term Decrease in Coloration: A Consequence of Climate Change?
López-Idiáquez D, Teplitsky C, Grégoire A, Fargevieille A, Del Rey M, de Franceschi C, Charmantier A, Doutrelant C. López-Idiáquez D, et al. Among authors: del rey m. Am Nat. 2022 Jul;200(1):32-47. doi: 10.1086/719655. Epub 2022 May 11. Am Nat. 2022. PMID: 35737990
Adherence to guidance for prioritizing higher risk groups for breast cancer screening during the COVID-19 pandemic in the Ontario Breast Screening Program: a descriptive study.
Chiarelli AM, Walker MJ, Espino-Hernandez G, Gray N, Salleh A, Adhihetty C, Gao J, Fienberg S, Rey MA, Rabeneck L. Chiarelli AM, et al. Among authors: rey ma. CMAJ Open. 2021 Dec 21;9(4):E1205-E1212. doi: 10.9778/cmajo.20200285. Print 2021 Oct-Dec. CMAJ Open. 2021. PMID: 34933878 Free PMC article.
INTERPRETATION: Prioritizing screening for those at higher risk for breast cancer may increase diagnostic yield and redirect resources to minimize potential long-term harms caused by the pandemic. This further supports the clinical utility of risk-stratified cancer screeni …
INTERPRETATION: Prioritizing screening for those at higher risk for breast cancer may increase diagnostic yield and redirect resources to mi …
TFAM-deficient mouse skin fibroblasts - an ex vivo model of mitochondrial dysfunction.
Del Rey MJ, Meroño C, Municio C, Usategui A, Mittelbrunn M, García-Consuegra I, Criado G, Pablos JL. Del Rey MJ, et al. Dis Model Mech. 2021 Aug 1;14(8):dmm048995. doi: 10.1242/dmm.048995. Epub 2021 Aug 25. Dis Model Mech. 2021. PMID: 34312668 Free PMC article.
Functionally, mito-stress and glycolysis-stress tests showed that mitochondrial dysfunction developed after long-term 4-OHT treatment in HP Cre(+) SK-FBs and was compensated by an increase in the glycolytic capacity. ...
Functionally, mito-stress and glycolysis-stress tests showed that mitochondrial dysfunction developed after long-term 4-OHT treatment …
Group Membership and Social and Personal Identities as Psychosocial Coping Resources to Psychological Consequences of the COVID-19 Confinement.
Alcover CM, Rodríguez F, Pastor Y, Thomas H, Rey M, Del Barrio JL. Alcover CM, et al. Among authors: rey m. Int J Environ Res Public Health. 2020 Oct 12;17(20):7413. doi: 10.3390/ijerph17207413. Int J Environ Res Public Health. 2020. PMID: 33053738 Free PMC article.
The confinement imposed by measures to deal with the COVID-19 pandemic may in the short and medium term have psychological and psychosocial consequences affecting the well-being and mental health of individuals. ...
The confinement imposed by measures to deal with the COVID-19 pandemic may in the short and medium term have psychological and psycho …
Efficacy and tolerability of a custom-made Narval mandibular repositioning device for the treatment of obstructive sleep apnea: ORCADES study 2-year follow-up data.
Attali V, Vecchierini MF, Collet JM, d'Ortho MP, Goutorbe F, Kerbrat JB, Leger D, Lavergne F, Monaca C, Monteyrol PJ, Morin L, Mullens E, Pigearias B, Martin F, Tordjman F, Khemliche H, Lerousseau L, Meurice JC; ORCADES investigators. Attali V, et al. Sleep Med. 2019 Nov;63:64-74. doi: 10.1016/j.sleep.2019.04.021. Epub 2019 Jun 12. Sleep Med. 2019. PMID: 31606651
The Orkney Complex Disease Study-ORCADES study is assessing the long-term efficacy and tolerability of MRD therapy in obstructive sleep apnoea syndrome (OSAS); two-year follow-up data are presented. ...
The Orkney Complex Disease Study-ORCADES study is assessing the long-term efficacy and tolerability of MRD therapy in obstructive sle …
41 results