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Impact of long-term treatment of onchocerciasis with ivermectin in Kaduna State, Nigeria: first evidence of the potential for elimination in the operational area of the African Programme for Onchocerciasis Control.
Parasit Vectors. 2012 Feb 7;5:28. doi: 10.1186/1756-3305-5-28.
Parasit Vectors. 2012.
PMID: 22313631
Free PMC article.
BACKGROUND: Onchocerciasis can be effectively controlled as a public health problem by annual mass drug administration of ivermectin, but it was not known if ivermectin treatment in the long term would be able to achieve elimination of onchocerciasis infection and interrup …
BACKGROUND: Onchocerciasis can be effectively controlled as a public health problem by annual mass drug administration of ivermectin, but it …
The impact of five years of annual ivermectin treatment on skin microfilarial loads in the onchocerciasis focus of Asubende, Ghana.
Alley ES, Plaisier AP, Boatin BA, Dadzie KY, Remme J, Zerbo G, Samba EM.
Alley ES, et al. Among authors: remme j.
Trans R Soc Trop Med Hyg. 1994 Sep-Oct;88(5):581-4. doi: 10.1016/0035-9203(94)90172-4.
Trans R Soc Trop Med Hyg. 1994.
PMID: 7992347
The study further emphasizes that even a single treatment with ivermectin has a significant medium-term impact on microfilarial loads. Microfilarial counts barely increased after 14-16 months of treatment and stabilized around 55% of pre-treatment counts 2-4 years after a …
The study further emphasizes that even a single treatment with ivermectin has a significant medium-term impact on microfilarial loads …
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Changes in ocular onchocerciasis four and twelve months after community-based treatment with ivermectin in a holoendemic onchocerciasis focus.
Dadzie KY, Remme J, Alley ES, de Sole G.
Dadzie KY, et al. Among authors: remme j.
Trans R Soc Trop Med Hyg. 1990 Jan-Feb;84(1):103-8. doi: 10.1016/0035-9203(90)90395-u.
Trans R Soc Trop Med Hyg. 1990.
PMID: 2345906
In view of the substantial increase of ocular microfilarial loads after 12 months, 6-monthly treatment may be indicated in such highly endemic foci. However, long-term observation is needed to give a correct estimate of the full benefit to be derived from mass treatment wi …
In view of the substantial increase of ocular microfilarial loads after 12 months, 6-monthly treatment may be indicated in such highly endem …
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Large scale ivermectin distribution and its epidemiological consequences.
Remme J, De Sole G, Dadzie KY, Alley ES, Baker RH, Habbema JD, Plaisier AP, van Oortmarssen GJ, Samba EM.
Remme J, et al.
Acta Leiden. 1990;59(1-2):177-91.
Acta Leiden. 1990.
PMID: 2198750
Review.
A summary is presented of the major, latest results on the short-term epidemiological impact of large scale ivermectin treatment, as observed in eight community trials undertaken in the Onchocerciasis Control Programme in West Africa (OCP). ...Preliminary results of comput …
A summary is presented of the major, latest results on the short-term epidemiological impact of large scale ivermectin treatment, as …
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A community trial of ivermectin in the onchocerciasis focus of Asubende, Ghana. I. Effect on the microfilarial reservoir and the transmission of Onchocerca volvulus.
Remme J, Baker RH, De Sole G, Dadzie KY, Walsh JF, Adams MA, Alley ES, Avissey HS.
Remme J, et al.
Trop Med Parasitol. 1989 Sep;40(3):367-74.
Trop Med Parasitol. 1989.
PMID: 2617046
However, the remaining level of transmission was still unacceptably high and further studies are required to predict the long term impact of repeated mass treatment....
However, the remaining level of transmission was still unacceptably high and further studies are required to predict the long term im …
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