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Cytokine Drizzle-The Rationale for Abandoning "Cytokine Storm".
Stolarski AE, Kim J, Zhang Q, Remick DG. Stolarski AE, et al. Among authors: remick dg. Shock. 2021 Nov 1;56(5):667-672. doi: 10.1097/SHK.0000000000001769. Shock. 2021. PMID: 34652339 Review.
Patients with autoimmune diseases have very low blood levels of cytokines (rheumatoid arthritis, IL-6 = 34 pg/mL; Crohn's disease, IL-6 = 5 pg/mL), yet respond dramatically to cytokine inhibitors. CONCLUSION: The misleading term "cytokine storm" implies increased blood lev …
Patients with autoimmune diseases have very low blood levels of cytokines (rheumatoid arthritis, IL-6 = 34 pg/mL; Crohn's disease, IL-6 = 5 …
Dissecting inflammatory complications in critically injured patients by within-patient gene expression changes: a longitudinal clinical genomics study.
Desai KH, Tan CS, Leek JT, Maier RV, Tompkins RG, Storey JD; Inflammation and the Host Response to Injury Large-Scale Collaborative Research Program. Desai KH, et al. PLoS Med. 2011 Sep;8(9):e1001093. doi: 10.1371/journal.pmed.1001093. Epub 2011 Sep 13. PLoS Med. 2011. PMID: 21931541 Free PMC article.
A quarter of the genome shows early expression changes associated with longer-term post-injury complications, captured by at least five dynamic co-expression modules of functionally related genes. In particular, early down-regulation of MHC-class II genes and up-regulation …
A quarter of the genome shows early expression changes associated with longer-term post-injury complications, captured by at least fi …
Inhibition of polymorphonuclear leukocyte-mediated graft damage synergizes with short-term costimulatory blockade to prevent cardiac allograft rejection.
El-Sawy T, Belperio JA, Strieter RM, Remick DG, Fairchild RL. El-Sawy T, et al. Among authors: remick dg. Circulation. 2005 Jul 19;112(3):320-31. doi: 10.1161/CIRCULATIONAHA.104.516708. Epub 2005 Jul 5. Circulation. 2005. PMID: 15998678
The influence of early PMN-mediated inflammation on the therapeutic efficacy of costimulatory blockade to prevent allograft rejection was tested. Short-term treatment of recipients with anti-CD154 mAb or CTLA-4 Ig induced modest prolongation of cardiac allograft survival. …
The influence of early PMN-mediated inflammation on the therapeutic efficacy of costimulatory blockade to prevent allograft rejection was te …
Under-resuscitation of near-lethal uncontrolled hemorrhage: effects on mortality and end-organ function at 72 hours.
Stern SA, Wang X, Mertz M, Chowanski ZP, Remick DG, Kim HM, Dronen SC. Stern SA, et al. Among authors: remick dg. Shock. 2001 Jan;15(1):16-23. doi: 10.1097/00024382-200115010-00003. Shock. 2001. PMID: 11198352
Laboratory studies of uncontrolled hemorrhage demonstrate that under resuscitation (UR) improves short-term survival, but at the expense of tissue perfusion. The long-term effects of UR have not been studied. ...
Laboratory studies of uncontrolled hemorrhage demonstrate that under resuscitation (UR) improves short-term survival, but at the expe …
Low molecular weight heparin is associated with greater cytokine production in a stimulated whole blood model.
Call DR, Remick DG. Call DR, et al. Among authors: remick dg. Shock. 1998 Sep;10(3):192-7. doi: 10.1097/00024382-199809000-00007. Shock. 1998. PMID: 9744647
Proinflammatory cytokines are produced in greater quantities with Fragmin anticoagulation, which may be a disadvantage for ischemic conditions (e.g., cardiac surgery) but advantageous for long-term treatment of thrombosis....
Proinflammatory cytokines are produced in greater quantities with Fragmin anticoagulation, which may be a disadvantage for ischemic conditio …
Intravascular plastic catheters. How they potentiate tumor necrosis factor release and exacerbate complications associated with sepsis.
Martin LF, Vary TC, Davis PK, Munger BL, Lynch JC, Spangler S, Remick DG. Martin LF, et al. Among authors: remick dg. Arch Surg. 1991 Sep;126(9):1087-93. doi: 10.1001/archsurg.1991.01410330041005. Arch Surg. 1991. PMID: 1929838
We tested the hypothesis that long-term intravascular cannulation exacerbates the harmful effects of an infectious challenge. ...
We tested the hypothesis that long-term intravascular cannulation exacerbates the harmful effects of an infectious challenge. ...