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Gaussian Mixture Models and Model Selection for [18F] Fluorodeoxyglucose Positron Emission Tomography Classification in Alzheimer's Disease.
Li R, Perneczky R, Yakushev I, Förster S, Kurz A, Drzezga A, Kramer S; Alzheimer’s Disease Neuroimaging Initiative. Li R, et al. PLoS One. 2015 Apr 28;10(4):e0122731. doi: 10.1371/journal.pone.0122731. eCollection 2014. PLoS One. 2015. PMID: 25919662 Free PMC article.
We present a method to discover discriminative brain metabolism patterns in [18F] fluorodeoxyglucose positron emission tomography (PET) scans, facilitating the clinical diagnosis of Alzheimer's disease. In the work, the term "pattern" stands for a certain brain region that …
We present a method to discover discriminative brain metabolism patterns in [18F] fluorodeoxyglucose positron emission tomography (PET) scan …
Intravenous immunoglobulins for Alzheimer's disease.
Puli L, Tanila H, Relkin N. Puli L, et al. Among authors: relkin n. Curr Alzheimer Res. 2014;11(7):626-36. doi: 10.2174/1567205011666140812113415. Curr Alzheimer Res. 2014. PMID: 25115546 Review.
In a double transgenic murine model of AD, intracerebral injection of IVIG causes suppression of Abeta fibril pathology whereas long term peripheral IVIG treatments causes elevation of total brain Abeta levels with no measurable impact on Abeta deposits or tendency for ind …
In a double transgenic murine model of AD, intracerebral injection of IVIG causes suppression of Abeta fibril pathology whereas long term …
Estimating long-term multivariate progression from short-term data.
Donohue MC, Jacqmin-Gadda H, Le Goff M, Thomas RG, Raman R, Gamst AC, Beckett LA, Jack CR Jr, Weiner MW, Dartigues JF, Aisen PS; Alzheimer's Disease Neuroimaging Initiative. Donohue MC, et al. Alzheimers Dement. 2014 Oct;10(5 Suppl):S400-10. doi: 10.1016/j.jalz.2013.10.003. Epub 2014 Mar 20. Alzheimers Dement. 2014. PMID: 24656849 Free PMC article.
We propose a general semiparametric model and iterative estimation procedure to estimate simultaneously the pathological timing and long-term growth curves. The resulting estimates of long-term progression are fine-tuned using cognitive trajectories derived from the …
We propose a general semiparametric model and iterative estimation procedure to estimate simultaneously the pathological timing and long- …
Influence of comorbidities in idiopathic normal pressure hydrocephalus - research and clinical care. A report of the ISHCSF task force on comorbidities in INPH.
Malm J, Graff-Radford NR, Ishikawa M, Kristensen B, Leinonen V, Mori E, Owler BK, Tullberg M, Williams MA, Relkin NR. Malm J, et al. Among authors: relkin nr. Fluids Barriers CNS. 2013 Jun 10;10(1):22. doi: 10.1186/2045-8118-10-22. Fluids Barriers CNS. 2013. PMID: 23758953 Free PMC article.
Future INPH research should focus on the contribution of comorbidity to overall morbidity, mortality and long-term outcomes....
Future INPH research should focus on the contribution of comorbidity to overall morbidity, mortality and long-term outcomes....
Disclosure of APOE genotype for risk of Alzheimer's disease.
Green RC, Roberts JS, Cupples LA, Relkin NR, Whitehouse PJ, Brown T, Eckert SL, Butson M, Sadovnick AD, Quaid KA, Chen C, Cook-Deegan R, Farrer LA; REVEAL Study Group. Green RC, et al. Among authors: relkin nr. N Engl J Med. 2009 Jul 16;361(3):245-54. doi: 10.1056/NEJMoa0809578. N Engl J Med. 2009. PMID: 19605829 Free PMC article. Clinical Trial.
CONCLUSIONS: The disclosure of APOE genotyping results to adult children of patients with Alzheimer's disease did not result in significant short-term psychological risks. Test-related distress was reduced among those who learned that they were APOE epsilon4-negative. ...
CONCLUSIONS: The disclosure of APOE genotyping results to adult children of patients with Alzheimer's disease did not result in significant …
Outcome of shunting in idiopathic normal-pressure hydrocephalus and the value of outcome assessment in shunted patients.
Klinge P, Marmarou A, Bergsneider M, Relkin N, Black PM. Klinge P, et al. Among authors: relkin n. Neurosurgery. 2005 Sep;57(3 Suppl):S40-52; discussion ii-v. doi: 10.1227/01.neu.0000168187.01077.2f. Neurosurgery. 2005. PMID: 16160428 Review.
CONCLUSION: Studies that have established fixed protocols for follow-up have shown that short- and long-term periods after shunting are determined by many factors. Whereas short-term results were more likely to be influenced by shunt-associated risks, long-term …
CONCLUSION: Studies that have established fixed protocols for follow-up have shown that short- and long-term periods after shunting a …