Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel.
Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1182-7. doi: 10.1073/pnas.98.3.1182.
Proc Natl Acad Sci U S A. 2001.
PMID: 11252306
Free PMC article.
Defects in polycystin-2, a ubiquitous transmembrane glycoprotein of unknown function, is a major cause of autosomal dominant polycystic kidney disease (ADPKD), whose manifestation entails the development of fluid-filled cysts in target organs. Here, we demonstrate that polycystin …
Defects in polycystin-2, a ubiquitous transmembrane glycoprotein of unknown function, is a major cause of autosomal dominant polycystic kidn …