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A randomised controlled trial in preterm infants comparing prophylactic with selective "less invasive surfactant administration" (pro.LISA).
Göpel W, Rausch TK, Mitschdörfer B, Mader S, Herting E, König IR, Stichtenoth G; pro.LISA study group. Göpel W, et al. Among authors: rausch tk. Trials. 2023 Sep 26;24(1):612. doi: 10.1186/s13063-023-07603-7. Trials. 2023. PMID: 37752593 Free PMC article. Clinical Trial.
Secondary endpoints include additional lung function parameters, endurance, motor development, intelligence, and sensitivity for infectious lung diseases. Short-term safety assessment will be done after completed enrolment (n = 698) and discharge of all infants. This safet …
Secondary endpoints include additional lung function parameters, endurance, motor development, intelligence, and sensitivity for infectious …
Observational study on the neonatal outcome during the COVID-19 pandemic in Germany.
Lau M, Kraus V, Schulze AF, Rausch TK, Krüger M, Göpel W. Lau M, et al. Among authors: rausch tk. Acta Paediatr. 2023 Sep;112(9):1892-1897. doi: 10.1111/apa.16873. Epub 2023 Jun 16. Acta Paediatr. 2023. PMID: 37306278
AIM: We aimed to determine stillbirth, preterm birth, perinatal complications, and the developmental outcome of children born preterm during the COVID-19 pandemic in Germany. METHODS: National data from the perinatal survey of preterm and term infants born in 2017-2 …
AIM: We aimed to determine stillbirth, preterm birth, perinatal complications, and the developmental outcome of children born preterm …
Recurrent Late-Onset Sepsis in Extremely Low Birth Weight Infants Is Associated with Motor Deficits in Early School Age.
Humberg A, Fortmann MI, Spiegler J, Rausch TK, Siller B, Silwedel C, Marissen J, Herting E, Göpel W, Härtel C; German Neonatal Network (GNN). Humberg A, et al. Among authors: rausch tk. Neonatology. 2022;119(6):695-702. doi: 10.1159/000525709. Epub 2022 Nov 3. Neonatology. 2022. PMID: 36327925
INTRODUCTION: Sepsis is regarded as a risk factor for brain injury in preterm infants. We herein hypothesize that extremely low birth weight infants (ELBWI, birth weight <1,000 g) having survived recurrent blood culture-proven late-onset sepsis (LOS) episodes are …
INTRODUCTION: Sepsis is regarded as a risk factor for brain injury in preterm infants. We herein hypothesize that extremely low birth …
Association of ApoE Genotypes and Recovery From Intracerebral Hemorrhage in Very Low Birth Weight Infants.
Humberg A, Dzietko M, Schulz S, Felderhoff-Müser U, Hüning B, Stein A, Fortmann MI, Marissen J, Rausch TK, Herting E, Härtel C, Göpel W; German Neonatal Network (GNN). Humberg A, et al. Among authors: rausch tk. Stroke. 2022 Feb;53(2):514-522. doi: 10.1161/STROKEAHA.120.033432. Epub 2021 Oct 8. Stroke. 2022. PMID: 34619984
METHODS: In this multicenter observational cohort study, very low birth weight (<1500 g, <32 weeks gestational age) children were studied for cerebral palsy (CP) after ultrasound diagnosed ICH stratified by APOE genotype. ...CONCLUSIONS: APOE-epsilon4 carriers have a …
METHODS: In this multicenter observational cohort study, very low birth weight (<1500 g, <32 weeks gestational age) children we …
Neonatal Outcome After Preeclampsia and HELLP Syndrome: A Population-Based Cohort Study in Germany.
Bossung V, Fortmann MI, Fusch C, Rausch T, Herting E, Swoboda I, Rody A, Härtel C, Göpel W, Humberg A. Bossung V, et al. Among authors: rausch t. Front Pediatr. 2020 Oct 12;8:579293. doi: 10.3389/fped.2020.579293. eCollection 2020. Front Pediatr. 2020. PMID: 33154958 Free PMC article.
Aim: To analyze short term outcomes of very low birth weight infants (VLBWI) born preterm after maternal preeclampsia and HELLP syndrome within the German Neonatal Network. ...Conclusions: The indication for preterm birth has an impact on neonatal outcome in …
Aim: To analyze short term outcomes of very low birth weight infants (VLBWI) born preterm after maternal preeclampsia and HELL …
Increased Regulatory T Cells Precede the Development of Bronchopulmonary Dysplasia in Preterm Infants.
Pagel J, Twisselmann N, Rausch TK, Waschina S, Hartz A, Steinbeis M, Olbertz J, Nagel K, Steinmetz A, Faust K, Demmert M, Göpel W, Herting E, Rupp J, Härtel C. Pagel J, et al. Among authors: rausch tk. Front Immunol. 2020 Sep 30;11:565257. doi: 10.3389/fimmu.2020.565257. eCollection 2020. Front Immunol. 2020. PMID: 33101284 Free PMC article.
The suppressive function of Tregs on CD4+CD25- T cells was compared in preterm, term and adult blood. We observed that extreme prematurity was associated with increased Treg frequencies which peaked in the second week of life. ...Tregs of preterm neonates had a higher immu …
The suppressive function of Tregs on CD4+CD25- T cells was compared in preterm, term and adult blood. We observed that extreme premat …
Vancomycin-induced ototoxicity in very-low-birthweight infants.
Marissen J, Fortmann I, Humberg A, Rausch TK, Simon A, Stein A, Schaible T, Eichhorn J, Wintgens J, Roll C, Heitmann F, Herting E, Göpel W, Härtel C. Marissen J, et al. Among authors: rausch tk. J Antimicrob Chemother. 2020 Aug 1;75(8):2291-2298. doi: 10.1093/jac/dkaa156. J Antimicrob Chemother. 2020. PMID: 32464660
CONCLUSIONS: Vancomycin exposure in VLBWI is associated with an increased, dose-dependent risk of pathological hearing test results at discharge and at 5 years of age. Prospective studies on long-term hearing impairment are needed....
CONCLUSIONS: Vancomycin exposure in VLBWI is associated with an increased, dose-dependent risk of pathological hearing test results at disch …
Surgical necrotizing enterocolitis but not spontaneous intestinal perforation is associated with adverse neurological outcome at school age.
Humberg A, Spiegler J, Fortmann MI, Zemlin M, Marissen J, Swoboda I, Rausch TK, Herting E, Göpel W, Härtel C; German Neonatal Network (GNN). Humberg A, et al. Among authors: rausch tk. Sci Rep. 2020 Feb 11;10(1):2373. doi: 10.1038/s41598-020-58761-6. Sci Rep. 2020. PMID: 32047169 Free PMC article.
Gastrointestinal complications during the neonatal period, i.e. necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP), are associated with adverse short-term outcome in very-low-birthweight infants (VLBWI, <1500 g birth weight). ...
Gastrointestinal complications during the neonatal period, i.e. necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP) …
The NSL complex maintains nuclear architecture stability via lamin A/C acetylation.
Karoutas A, Szymanski W, Rausch T, Guhathakurta S, Rog-Zielinska EA, Peyronnet R, Seyfferth J, Chen HR, de Leeuw R, Herquel B, Kimura H, Mittler G, Kohl P, Medalia O, Korbel JO, Akhtar A. Karoutas A, et al. Among authors: rausch t. Nat Cell Biol. 2019 Oct;21(10):1248-1260. doi: 10.1038/s41556-019-0397-z. Epub 2019 Oct 1. Nat Cell Biol. 2019. PMID: 31576060
We found that nuclear abnormalities include EZH2-dependent histone H3 Lys 27 trimethylation and loss of nascent transcription. We term this altered epigenetic landscape "heterochromatin enrichment in nuclear abnormalities" (HENA). ...
We found that nuclear abnormalities include EZH2-dependent histone H3 Lys 27 trimethylation and loss of nascent transcription. We term …
Prevalence of Congenital CMV Infection and Antiviral Therapy in Very-Low-Birth-Weight Infants: Observations of the German Neonatal Network.
Humberg A, Leienbach V, Fortmann MI, Rausch TK, Buxmann H, Müller A, Herting E, Härtel C, Göpel W. Humberg A, et al. Among authors: rausch tk. Klin Padiatr. 2018 Sep;230(5):257-262. doi: 10.1055/a-0598-4748. Epub 2018 Apr 18. Klin Padiatr. 2018. PMID: 29669381 English.
BACKGROUND: To determine the prevalence of congenital CMV infection (cCMV) in very-low-birth-weight infants (VLBWI) and to evaluate epidemiological characteristics of VLBWI with antiviral therapy (AT). ...VLBWI with AT and negative PCR had significantly reduced mean bir …
BACKGROUND: To determine the prevalence of congenital CMV infection (cCMV) in very-low-birth-weight infants (VLBWI) and to evaluate e …
14 results