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C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis.
Perrino MR, Ahmari N, Hall A, Jackson M, Na Y, Pundavela J, Szabo S, Woodruff TM, Dombi E, Kim MO, Köhl J, Wu J, Ratner N. Perrino MR, et al. Among authors: ratner n. Life Sci Alliance. 2024 Mar 8;7(5):e202302229. doi: 10.26508/lsa.202302229. Print 2024 May. Life Sci Alliance. 2024. PMID: 38458648 Free PMC article.
MEK inhibition recruited C5AR1 to the macrophage surface; short-term inhibition of C5aR elevated macrophage apoptosis and Schwann cell death, without affecting MEK-induced tumor shrinkage. ...
MEK inhibition recruited C5AR1 to the macrophage surface; short-term inhibition of C5aR elevated macrophage apoptosis and Schwann cel …
Language profiles in children with concussion.
Stockbridge MD, Newman RS, Zukowski A, Slawson KK, Doran A, Ratner NB. Stockbridge MD, et al. Among authors: ratner nb. Brain Inj. 2020 Mar 20;34(4):567-574. doi: 10.1080/02699052.2020.1725836. Epub 2020 Feb 12. Brain Inj. 2020. PMID: 32050797
iGEAK: an interactive gene expression analysis kit for seamless workflow using the R/shiny platform.
Choi K, Ratner N. Choi K, et al. Among authors: ratner n. BMC Genomics. 2019 Mar 6;20(1):177. doi: 10.1186/s12864-019-5548-x. BMC Genomics. 2019. PMID: 30841853 Free PMC article.
To avoid bottlenecks impeding seamless analysis processing, we have developed an Interactive Gene Expression Analysis Kit, we term iGEAK, focusing on usability and interactivity. iGEAK is designed to be a simple, intuitive, light-weight that contrasts with heavy-duty progr …
To avoid bottlenecks impeding seamless analysis processing, we have developed an Interactive Gene Expression Analysis Kit, we term iG …
Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future.
Reilly KM, Kim A, Blakely J, Ferner RE, Gutmann DH, Legius E, Miettinen MM, Randall RL, Ratner N, Jumbé NL, Bakker A, Viskochil D, Widemann BC, Stewart DR. Reilly KM, et al. Among authors: ratner n. J Natl Cancer Inst. 2017 Aug 1;109(8):djx124. doi: 10.1093/jnci/djx124. J Natl Cancer Inst. 2017. PMID: 29117388 Free PMC article. Review.
In 2016, an international meeting entitled "MPNST State of the Science: Outlining a Research Agenda for the Future" was convened to establish short- and long-term research priorities. Key recommendations included the: 1) development of standardized, cost-efficient fluorode …
In 2016, an international meeting entitled "MPNST State of the Science: Outlining a Research Agenda for the Future" was convened to establis …
Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation.
Currier MA, Sprague L, Rizvi TA, Nartker B, Chen CY, Wang PY, Hutzen BJ, Franczek MR, Patel AV, Chaney KE, Streby KA, Ecsedy JA, Conner J, Ratner N, Cripe TP. Currier MA, et al. Among authors: ratner n. Oncotarget. 2017 Mar 14;8(11):17412-17427. doi: 10.18632/oncotarget.14885. Oncotarget. 2017. PMID: 28147331 Free PMC article.
First, oncolytic herpes virus increased the sensitivity of uninfected cells to alisertib cytotoxicity, a process we term virus-induced therapeutic adjuvant (VITA). Second, alisertib increased peak virus production and slowed virus clearance from tumors, both likely a conse …
First, oncolytic herpes virus increased the sensitivity of uninfected cells to alisertib cytotoxicity, a process we term virus-induce …
Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas.
Dombi E, Baldwin A, Marcus LJ, Fisher MJ, Weiss B, Kim A, Whitcomb P, Martin S, Aschbacher-Smith LE, Rizvi TA, Wu J, Ershler R, Wolters P, Therrien J, Glod J, Belasco JB, Schorry E, Brofferio A, Starosta AJ, Gillespie A, Doyle AL, Ratner N, Widemann BC. Dombi E, et al. Among authors: ratner n. N Engl J Med. 2016 Dec 29;375(26):2550-2560. doi: 10.1056/NEJMoa1605943. N Engl J Med. 2016. PMID: 28029918 Free PMC article. Clinical Trial.
RESULTS: A total of 24 children (median age, 10.9 years; range, 3.0 to 18.5) with a median tumor volume of 1205 ml (range, 29 to 8744) received selumetinib. Patients were able to receive selumetinib on a long-term basis; the median number of cycles was 30 (range, 6 to 56). …
RESULTS: A total of 24 children (median age, 10.9 years; range, 3.0 to 18.5) with a median tumor volume of 1205 ml (range, 29 to 8744) recei …
Veridical and false recall in adults who stutter.
Byrd CT, Sheng L, Ratner NB, Gkalitsiou Z. Byrd CT, et al. Among authors: ratner nb. J Speech Lang Hear Res. 2015 Feb;58(1):28-42. doi: 10.1044/2014_JSLHR-S-13-0301. J Speech Lang Hear Res. 2015. PMID: 25321141
Comparative pathology of nerve sheath tumors in mouse models and humans.
Stemmer-Rachamimov AO, Louis DN, Nielsen GP, Antonescu CR, Borowsky AD, Bronson RT, Burns DK, Cervera P, McLaughlin ME, Reifenberger G, Schmale MC, MacCollin M, Chao RC, Cichowski K, Kalamarides M, Messerli SM, McClatchey AI, Niwa-Kawakita M, Ratner N, Reilly KM, Zhu Y, Giovannini M. Stemmer-Rachamimov AO, et al. Among authors: ratner n. Cancer Res. 2004 May 15;64(10):3718-24. doi: 10.1158/0008-5472.CAN-03-4079. Cancer Res. 2004. PMID: 15150133
Despite the progress made in our understanding of the biology of neurofibromatosis (NF), the long-term clinical outcome for affected patients has not changed significantly in the past decades, and both NF1 and NF2 are still associated with a significant morbidity and a dec …
Despite the progress made in our understanding of the biology of neurofibromatosis (NF), the long-term clinical outcome for affected …