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Intranasal Nanoparticle Vaccination Elicits a Persistent, Polyfunctional CD4 T Cell Response in the Murine Lung Specific for a Highly Conserved Influenza Virus Antigen That Is Sufficient To Mediate Protection from Influenza Virus Challenge.
Nelson SA, Dileepan T, Rasley A, Jenkins MK, Fischer NO, Sant AJ. Nelson SA, et al. Among authors: rasley a. J Virol. 2021 Jul 26;95(16):e0084121. doi: 10.1128/JVI.00841-21. Epub 2021 Jul 26. J Virol. 2021. PMID: 34076479 Free PMC article.
Our study revealed that intranasal vaccination elicits a polyfunctional subset of lung-localized CD4 T cells that persist long term. A subset of these lung CD4 T cells localize to the airway, where they can act as early responders following encounter with cognate antigen. …
Our study revealed that intranasal vaccination elicits a polyfunctional subset of lung-localized CD4 T cells that persist long term. …
Cell-free production of a functional oligomeric form of a Chlamydia major outer-membrane protein (MOMP) for vaccine development.
He W, Felderman M, Evans AC, Geng J, Homan D, Bourguet F, Fischer NO, Li Y, Lam KS, Noy A, Xing L, Cheng RH, Rasley A, Blanchette CD, Kamrud K, Wang N, Gouvis H, Peterson TC, Hubby B, Coleman MA. He W, et al. Among authors: rasley a. J Biol Chem. 2017 Sep 8;292(36):15121-15132. doi: 10.1074/jbc.M117.784561. Epub 2017 Jul 24. J Biol Chem. 2017. PMID: 28739800 Free PMC article.
Although most individuals infected with Chlamydia trachomatis are initially asymptomatic, symptoms can arise if left undiagnosed. Long-term infection can result in debilitating conditions such as pelvic inflammatory disease, infertility, and blindness. ...
Although most individuals infected with Chlamydia trachomatis are initially asymptomatic, symptoms can arise if left undiagnosed. Long-te …
Structure and function of REP34 implicates carboxypeptidase activity in Francisella tularensis host cell invasion.
Feld GK, El-Etr S, Corzett MH, Hunter MS, Belhocine K, Monack DM, Frank M, Segelke BW, Rasley A. Feld GK, et al. Among authors: rasley a. J Biol Chem. 2014 Oct 31;289(44):30668-30679. doi: 10.1074/jbc.M114.599381. Epub 2014 Sep 17. J Biol Chem. 2014. PMID: 25231992 Free PMC article.
Previously, we identified seven F. tularensis proteins that induce a rapid encystment phenotype (REP) in the free-living amoeba, Acanthamoeba castellanii. Encystment is essential to the pathogen's long term intracellular survival in the amoeba. Here, we characterize the ce …
Previously, we identified seven F. tularensis proteins that induce a rapid encystment phenotype (REP) in the free-living amoeba, Acanthamoeb …