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BAL Inflammatory Markers Can Predict Pulmonary Exacerbations in Children With Cystic Fibrosis.
Ishak A, Stick SM, Turkovic L, Ranganathan SC, King L, Harrison J, Sly PD, Caudri D, Schultz A; AREST CF. Ishak A, et al. Among authors: ranganathan sc. Chest. 2020 Dec;158(6):2314-2322. doi: 10.1016/j.chest.2020.06.044. Epub 2020 Jul 3. Chest. 2020. PMID: 32622821
Early identification of such exacerbations may facilitate early initiation of treatment, thereby potentially reducing long-term morbidity. RESEARCH QUESTION: Is it possible to predict pulmonary exacerbations in children with cystic fibrosis, using inflammatory markers obta …
Early identification of such exacerbations may facilitate early initiation of treatment, thereby potentially reducing long-term morbi …
Single-Cell Flow Cytometry Profiling of BAL in Children.
Shanthikumar S, Burton M, Saffery R, Ranganathan SC, Neeland MR. Shanthikumar S, et al. Among authors: ranganathan sc. Am J Respir Cell Mol Biol. 2020 Aug;63(2):152-159. doi: 10.1165/rcmb.2019-0453MA. Am J Respir Cell Mol Biol. 2020. PMID: 32207982
Childhood pulmonary diseases not only cause childhood morbidity and mortality but also can cause long-term pulmonary impairment. The clinical management of many childhood pulmonary diseases is hampered by a limited understanding of the underlying pathophysiological mechani …
Childhood pulmonary diseases not only cause childhood morbidity and mortality but also can cause long-term pulmonary impairment. The …
Structural determinants of long-term functional outcomes in young children with cystic fibrosis.
Turkovic L, Caudri D, Rosenow T, Breuer O, Murray C, Tiddens HAWM, Ramanauskas F, Ranganathan SC, Hall GL, Stick SM; AREST CF. Turkovic L, et al. Among authors: ranganathan sc. Eur Respir J. 2020 May 21;55(5):1900748. doi: 10.1183/13993003.00748-2019. Print 2020 May. Eur Respir J. 2020. PMID: 32139454 Free article.
DISCUSSION: Chest CT identifies children at an early age who have adverse long-term outcomes. The prevention of structural lung damage should be a goal of early intervention and can be usefully assessed with chest CT. In an era of therapeutics that might alter disease traj …
DISCUSSION: Chest CT identifies children at an early age who have adverse long-term outcomes. The prevention of structural lung damag …
Early Lung Disease in Infants and Preschool Children with Cystic Fibrosis. What Have We Learned and What Should We Do about It?
Ranganathan SC, Hall GL, Sly PD, Stick SM, Douglas TA; Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST-CF). Ranganathan SC, et al. Am J Respir Crit Care Med. 2017 Jun 15;195(12):1567-1575. doi: 10.1164/rccm.201606-1107CI. Am J Respir Crit Care Med. 2017. PMID: 27911585 Free PMC article. Review.
Early childhood represents a pivotal period amenable to intervention strategies that could delay or prevent the onset of lung damage and alter the longer-term clinical trajectory for individuals with CF. This review summarizes what we have learned about early lung disease …
Early childhood represents a pivotal period amenable to intervention strategies that could delay or prevent the onset of lung damage and alt …
Respiratory function during infancy in survivors of the INNOVO trial.
Hoo AF, Beardsmore CS, Castle RA, Ranganathan SC, Tomlin K, Field D, Elbourne D, Stocks J; INNOVO Trial Collaborating Group. Hoo AF, et al. Among authors: ranganathan sc. Pediatr Pulmonol. 2009 Feb;44(2):155-61. doi: 10.1002/ppul.20967. Pediatr Pulmonol. 2009. PMID: 19148936
RATIONALE: Despite encouraging reports suggesting that inhaled nitric oxide (iNO) appear to improve outcome in hypoxemic term and near term infants by improving oxygenation and reducing need for ECMO, the long-term benefits of iNO remain unclear. ...CONCLUSIO …
RATIONALE: Despite encouraging reports suggesting that inhaled nitric oxide (iNO) appear to improve outcome in hypoxemic term and nea …
Airway function in infants treated with inhaled nitric oxide for persistent pulmonary hypertension.
Hoskote AU, Castle RA, Hoo AF, Lum S, Ranganathan SC, Mok QQ, Stocks J. Hoskote AU, et al. Among authors: ranganathan sc. Pediatr Pulmonol. 2008 Mar;43(3):224-35. doi: 10.1002/ppul.20733. Pediatr Pulmonol. 2008. PMID: 18203182
Deferring ECMO with iNO in these neonates could potentially have long-term detrimental effects on lung function. We studied respiratory morbidity (defined as occurrence of respiratory infections requiring treatment, episodes of wheezing, and/or need for ongoing medications …
Deferring ECMO with iNO in these neonates could potentially have long-term detrimental effects on lung function. We studied respirato …
Clinical scoring systems in cystic fibrosis.
Hafen GM, Ranganathan SC, Robertson CF, Robinson PJ. Hafen GM, et al. Among authors: ranganathan sc. Pediatr Pulmonol. 2006 Jul;41(7):602-17. doi: 10.1002/ppul.20376. Pediatr Pulmonol. 2006. PMID: 16703586 Review.
Of the current scoring systems, the modified Shwachman score by Doershuk is perhaps most reliable for describing follow-up studies. Scores designed for acute changes and short-term evaluation were also developed. The modified Huang score may be useful in the prognostic eva …
Of the current scoring systems, the modified Shwachman score by Doershuk is perhaps most reliable for describing follow-up studies. Scores d …