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Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy.
Gromeier M, Brown MC, Zhang G, Lin X, Chen Y, Wei Z, Beaubier N, Yan H, He Y, Desjardins A, Herndon JE 2nd, Varn FS, Verhaak RG, Zhao J, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Lipp ES, Nair SK, Khasraw M, Peters KB, Randazzo D, Sampson JH, McLendon RE, Bigner DD, Ashley DM. Gromeier M, et al. Among authors: randazzo d. Nat Commun. 2021 Jan 13;12(1):352. doi: 10.1038/s41467-020-20469-6. Nat Commun. 2021. PMID: 33441554 Free PMC article.
Several immunotherapy clinical trials in recurrent glioblastoma have reported long-term survival benefits in 10-20% of patients. Here we perform genomic analysis of tumor tissue from recurrent WHO grade IV glioblastoma patients acquired prior to immunotherapy intervention. …
Several immunotherapy clinical trials in recurrent glioblastoma have reported long-term survival benefits in 10-20% of patients. Here …
Pineal Region Glioblastoma, a Case Report and Literature Review.
Stowe HB, Miller CR, Wu J, Randazzo DM, Ju AW. Stowe HB, et al. Among authors: randazzo dm. Front Oncol. 2017 Jun 12;7:123. doi: 10.3389/fonc.2017.00123. eCollection 2017. Front Oncol. 2017. PMID: 28660172 Free PMC article.
CONCLUDING REMARKS: Although pineal region GBM is a rare disease entity with a generally poor prognosis, long-term survival is achievable for select patients. MGMT promoter methylation may potentially have prognostic value. ...
CONCLUDING REMARKS: Although pineal region GBM is a rare disease entity with a generally poor prognosis, long-term survival is achiev …
Legacy persistent organic pollutants including PBDEs in the trophic web of the Ross Sea (Antarctica).
Corsolini S, Ademollo N, Martellini T, Randazzo D, Vacchi M, Cincinelli A. Corsolini S, et al. Among authors: randazzo d. Chemosphere. 2017 Oct;185:699-708. doi: 10.1016/j.chemosphere.2017.07.054. Epub 2017 Jul 12. Chemosphere. 2017. PMID: 28732330
The average PBDEs was 0.19-1.35 pg/g wet wt in the key-species and one-two order of magnitude higher in the predators. Penguins and skuas from an area where a long-term field camp is located showed higher BDE concentrations. The sigmaDDTs was higher in the Antarctic toothf …
The average PBDEs was 0.19-1.35 pg/g wet wt in the key-species and one-two order of magnitude higher in the predators. Penguins and skuas fr …
Long-term environmental exposure to metals (Cu, Cd, Pb, Zn) activates the immune cell stress response in the common European sea star (Asterias rubens).
Matranga V, Pinsino A, Randazzo D, Giallongo A, Dubois P. Matranga V, et al. Among authors: randazzo d. Mar Environ Res. 2012 May;76:122-7. doi: 10.1016/j.marenvres.2011.09.008. Epub 2011 Sep 28. Mar Environ Res. 2012. PMID: 22000270
We show that levels of the heat shock cognate protein 70 (HSC70) in coelomocytes from A. rubens, which were collected during a field study in the Sorfjord (North Sea, SW coast of Norway) along a contamination gradient, are directly associated with the long-term accumulatio …
We show that levels of the heat shock cognate protein 70 (HSC70) in coelomocytes from A. rubens, which were collected during a field study i …