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Systemic Corticosteroids in the Management of Pediatric Cystic Fibrosis Pulmonary Exacerbations.
Davis CS, Faino AV, Onchiri F, Gibson RL, Merjaneh L, Ramsey BW, Rosenfeld M, Cogen JD. Davis CS, et al. Among authors: ramsey bw. Ann Am Thorac Soc. 2023 Jan;20(1):75-82. doi: 10.1513/AnnalsATS.202203-201OC. Ann Am Thorac Soc. 2023. PMID: 36044723
CF Foundation PEx guidelines note that a short course of systemic corticosteroids may offer benefit without contributing to long-term adverse effects. However, insufficient evidence exists to recommend systemic corticosteroids for PEx treatment. ...
CF Foundation PEx guidelines note that a short course of systemic corticosteroids may offer benefit without contributing to long-term …
Long-term azithromycin use is not associated with QT prolongation in children with cystic fibrosis.
Magaret AS, Salerno J, Deen JF, Kloster M, Mayer-Hamblett N, Ramsey BW, Nichols DP. Magaret AS, et al. Among authors: ramsey bw. J Cyst Fibros. 2021 Mar;20(2):e16-e18. doi: 10.1016/j.jcf.2020.11.005. Epub 2020 Nov 24. J Cyst Fibros. 2021. PMID: 33246911 Free PMC article.
Among 221 study participants with a median of 18 months follow-up, increased corrected QT interval (QTc) of 30 msec was rare, at 3.4 occurrences per 100 person-years; and incidence of QTc prolongation was no higher in the AZM arm than the placebo arm (1.8 versus 5.4 per 100 perso …
Among 221 study participants with a median of 18 months follow-up, increased corrected QT interval (QTc) of 30 msec was rare, at 3.4 occurre …
Impact of Sustained Eradication of New Pseudomonas aeruginosa Infection on Long-term Outcomes in Cystic Fibrosis.
Mayer-Hamblett N, Kloster M, Rosenfeld M, Gibson RL, Retsch-Bogart GZ, Emerson J, Thompson V, Ramsey BW. Mayer-Hamblett N, et al. Among authors: ramsey bw. Clin Infect Dis. 2015 Sep 1;61(5):707-15. doi: 10.1093/cid/civ377. Epub 2015 May 13. Clin Infect Dis. 2015. PMID: 25972024 Free PMC article. Clinical Trial.
A key question is whether children with newly acquired Pa infection who are able to achieve sustained eradication after early antipseudomonal therapy demonstrate improved long-term health outcomes compared with those who are unable to achieve a sustained microbiologic resp …
A key question is whether children with newly acquired Pa infection who are able to achieve sustained eradication after early antipseudomona …
Use of lung imaging studies as outcome measures for development of new therapies in cystic fibrosis.
Ramsey BW. Ramsey BW. Proc Am Thorac Soc. 2007 Aug 1;4(4):359-63. doi: 10.1513/pats.200611-183HT. Proc Am Thorac Soc. 2007. PMID: 17652502 Free PMC article. Review.
For postmarketing therapeutic use trials, CT scans could play an important role in defining long-term efficacy in subpopulations, such as infants and children. Further steps need to be taken to optimize imaging biomarkers. ...
For postmarketing therapeutic use trials, CT scans could play an important role in defining long-term efficacy in subpopulations, suc …
Respiratory adverse event profiles in cystic fibrosis placebo subjects in short- and long-term inhaled therapy trials.
Sucharew H, Goss CH, Millard SP, Ramsey BW; Cystic Fibrosis Therapeutics Development Network. Sucharew H, et al. Among authors: ramsey bw. Contemp Clin Trials. 2006 Dec;27(6):561-70. doi: 10.1016/j.cct.2006.06.001. Epub 2006 Jun 9. Contemp Clin Trials. 2006. PMID: 16875884
In long-term studies, respiratory AE rates were 1.7(1.6, 1.8)/person-month and 2.2(2.1, 2.3)/person-month in pediatric and adult subjects, respectively. ...Forced expiratory volume in one second (FEV(1)) percent of predicted and age in short-term studies, and FEV(1) …
In long-term studies, respiratory AE rates were 1.7(1.6, 1.8)/person-month and 2.2(2.1, 2.3)/person-month in pediatric and adult subj …
Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients.
Smith EE, Buckley DG, Wu Z, Saenphimmachak C, Hoffman LR, D'Argenio DA, Miller SI, Ramsey BW, Speert DP, Moskowitz SM, Burns JL, Kaul R, Olson MV. Smith EE, et al. Among authors: ramsey bw. Proc Natl Acad Sci U S A. 2006 May 30;103(22):8487-92. doi: 10.1073/pnas.0602138103. Epub 2006 May 10. Proc Natl Acad Sci U S A. 2006. PMID: 16687478 Free PMC article.
With the exception of intensively studied viral infections such as HIV/AIDs, little is known about the extent to which the clonal expansion that occurs during long-term infection by pathogens involves important genetic adaptations. ...
With the exception of intensively studied viral infections such as HIV/AIDs, little is known about the extent to which the clonal expansion …
Pseudomonas acquisition in young patients with cystic fibrosis: pathophysiology, diagnosis, and management.
Rosenfeld M, Ramsey BW, Gibson RL. Rosenfeld M, et al. Among authors: ramsey bw. Curr Opin Pulm Med. 2003 Nov;9(6):492-7. doi: 10.1097/00063198-200311000-00008. Curr Opin Pulm Med. 2003. PMID: 14534401 Review.
There is a critical need for further investigation of the clinical outcomes associated with early intervention, the long-term safety profile, and the optimal drug regimen....
There is a critical need for further investigation of the clinical outcomes associated with early intervention, the long-term safety …
Nutritional effects of long-term gastrostomy feedings in children with cystic fibrosis.
Rosenfeld M, Casey S, Pepe M, Ramsey BW. Rosenfeld M, et al. Among authors: ramsey bw. J Am Diet Assoc. 1999 Feb;99(2):191-4. doi: 10.1016/S0002-8223(99)00046-2. J Am Diet Assoc. 1999. PMID: 9972186
OBJECTIVE: To analyze the long-term nutritional effects of supplemental gastrostomy feedings in undernourished patients with cystic fibrosis. ...Gastrostomy feedings were well tolerated and associated with only minor complications. CONCLUSIONS: Long-term gastrostomy …
OBJECTIVE: To analyze the long-term nutritional effects of supplemental gastrostomy feedings in undernourished patients with cystic f …
Efficacy of aerosolized tobramycin in patients with cystic fibrosis.
Ramsey BW, Dorkin HL, Eisenberg JD, Gibson RL, Harwood IR, Kravitz RM, Schidlow DV, Wilmott RW, Astley SJ, McBurnie MA, et al. Ramsey BW, et al. N Engl J Med. 1993 Jun 17;328(24):1740-6. doi: 10.1056/NEJM199306173282403. N Engl J Med. 1993. PMID: 8497284 Free article. Clinical Trial.
The frequency of the emergence of tobramycin-resistant bacteria was similar during both tobramycin and placebo administration. CONCLUSIONS: The short-term aerosol administration of a high dose of tobramycin in patients with clinically stable cystic fibrosis is an efficacio …
The frequency of the emergence of tobramycin-resistant bacteria was similar during both tobramycin and placebo administration. CONCLUSIONS: …
11 results