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C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation.
Manion J, Musser MA, Kuziel GA, Liu M, Shepherd A, Wang S, Lee PG, Zhao L, Zhang J, Marreddy RKR, Goldsmith JD, Yuan K, Hurdle JG, Gerhard R, Jin R, Rakoff-Nahoum S, Rao M, Dong M. Manion J, et al. Among authors: rakoff nahoum s. Nature. 2023 Oct;622(7983):611-618. doi: 10.1038/s41586-023-06607-2. Epub 2023 Sep 12. Nature. 2023. PMID: 37699522
Targeted delivery of the TcdB enzymatic domain, through fusion with a detoxified diphtheria toxin, into peptidergic sensory neurons that express exogeneous diphtheria toxin receptor (an approach we term toxogenetics) is sufficient to induce neurogenic inflammation and reca …
Targeted delivery of the TcdB enzymatic domain, through fusion with a detoxified diphtheria toxin, into peptidergic sensory neurons that exp …
Stress ulcer prophylaxis versus placebo-a blinded randomized control trial to evaluate the safety of two strategies in critically ill infants with congenital heart disease (SUPPRESS-CHD).
Mills KI, Albert BD, Bechard LJ, Duggan CP, Kaza A, Rakoff-Nahoum S, Vlamakis H, Sleeper LA, Newburger JW, Priebe GP, Mehta NM. Mills KI, et al. Among authors: rakoff nahoum s. Trials. 2020 Jun 29;21(1):590. doi: 10.1186/s13063-020-04513-w. Trials. 2020. PMID: 32600393 Free PMC article.
Registered 12 September 2018, https://clinicaltrials.gov/ct2/show/NCT03667703?term=SUPPRESS+CHD&draw=2&rank=1 . All WHO Trial Registration Data Set Criteria are met in this manuscript....
Registered 12 September 2018, https://clinicaltrials.gov/ct2/show/NCT03667703?term=SUPPRESS+CHD&draw=2&rank=1 . All WHO Trial …
Distribution and storage of inflammatory memory in barrier tissues.
Ordovas-Montanes J, Beyaz S, Rakoff-Nahoum S, Shalek AK. Ordovas-Montanes J, et al. Among authors: rakoff nahoum s. Nat Rev Immunol. 2020 May;20(5):308-320. doi: 10.1038/s41577-019-0263-z. Epub 2020 Feb 3. Nat Rev Immunol. 2020. PMID: 32015472 Free PMC article. Review.
To effectively inform future responses, these past experiences can be stored in cell types that are long-term residents or essential constituents of tissues. There is an emerging understanding that, in addition to antigen-specific immune cells, diverse haematopoietic, stro …
To effectively inform future responses, these past experiences can be stored in cell types that are long-term residents or essential …