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The evolving role of dendritic spines and memory: Interaction(s) with estradiol.
Frankfurt M, Luine V. Frankfurt M, et al. Horm Behav. 2015 Aug;74:28-36. doi: 10.1016/j.yhbeh.2015.05.004. Epub 2015 May 17. Horm Behav. 2015. PMID: 25993604 Free PMC article. Review.
The present paper reviews the literature on dendritic spine plasticity in mediating both short and long term memory, as well as the decreased memory that occurs with aging and Alzheimer's disease. ...
The present paper reviews the literature on dendritic spine plasticity in mediating both short and long term memory, as well as the d …
A p53-independent role of Mdm2 in estrogen-mediated activation of breast cancer cell proliferation.
Brekman A, Singh KE, Polotskaia A, Kundu N, Bargonetti J. Brekman A, et al. Breast Cancer Res. 2011 Jan 11;13(1):R3. doi: 10.1186/bcr2804. Breast Cancer Res. 2011. PMID: 21223569 Free PMC article.
We investigated if estrogen signaling in such breast cancers occurred through an Mdm2 mediated pathway with subsequent inactivation of p53. METHODS: We examined the effect of long-term 17beta-estradiol (E2) treatment (five days) on the p53-Mdm2 pathway in estrogen receptor …
We investigated if estrogen signaling in such breast cancers occurred through an Mdm2 mediated pathway with subsequent inactivation of p53. …
Sex-dependent changes in anxiety, memory, and monoamines following one week of stress.
Bowman RE, Micik R, Gautreaux C, Fernandez L, Luine VN. Bowman RE, et al. Physiol Behav. 2009 Apr 20;97(1):21-9. doi: 10.1016/j.physbeh.2009.01.012. Epub 2009 Jan 22. Physiol Behav. 2009. PMID: 19419681
Thus, these sexually dimorphic neurochemical changes following stress may underlie the behavioral differences. Current results show that short-term restraint elicits sex-dependent behavioral and neural changes different from those previously reported for longer term …
Thus, these sexually dimorphic neurochemical changes following stress may underlie the behavioral differences. Current results show that sho …
The role of translational research in addressing health disparities: a conceptual framework.
Fleming ES, Perkins J, Easa D, Conde JG, Baker RS, Southerland WM, Dottin R, Benabe JE, Ofili EO, Bond VC, McClure SA, Sayre MH, Beanan MJ, Norris KC. Fleming ES, et al. Ethn Dis. 2008 Spring;18(2 Suppl 2):S2-155-60. Ethn Dis. 2008. PMID: 18646340 Free PMC article.
Translational research has tremendous potential as a tool to reduce health disparities in the United States, but a lack of common understanding about the scope of this dynamic, multidisciplinary approach to research has limited its use. The term "translational research" is …
Translational research has tremendous potential as a tool to reduce health disparities in the United States, but a lack of common understand …
Chronic stress and neural function: accounting for sex and age.
Luine VN, Beck KD, Bowman RE, Frankfurt M, Maclusky NJ. Luine VN, et al. J Neuroendocrinol. 2007 Oct;19(10):743-51. doi: 10.1111/j.1365-2826.2007.01594.x. J Neuroendocrinol. 2007. PMID: 17850456 Review.
Cognitive responses to stress follow the temporally dependent pattern originally established by Selye (1) wherein short-term stressors elicit adaptive responses whereas continued stress (chronic) results in maladaptive changes--deleterious effects on physiological systems …
Cognitive responses to stress follow the temporally dependent pattern originally established by Selye (1) wherein short-term stressor …
Ral and Rho-dependent activation of phospholipase D in v-Raf-transformed cells.
Frankel P, Ramos M, Flom J, Bychenok S, Joseph T, Kerkhoff E, Rapp UR, Feig LA, Foster DA. Frankel P, et al. Biochem Biophys Res Commun. 1999 Feb 16;255(2):502-7. doi: 10.1006/bbrc.1999.0234. Biochem Biophys Res Commun. 1999. PMID: 10049738
The dependence upon Ral was particularly surprising since Ral is a downstream target of Ras, which is an upstream activator of Raf. Depleting cells of PKC by long term phorbol ester treatment actually increased PLD activity in v-Raf-transformed cells, indicating that v-Raf …
The dependence upon Ral was particularly surprising since Ral is a downstream target of Ras, which is an upstream activator of Raf. Depletin …