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Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal.
Kuehnemann C, Hughes JB, Desprez PY, Melov S, Wiley CD, Campisi J. Kuehnemann C, et al. Aging Cell. 2023 Jan;22(1):e13750. doi: 10.1111/acel.13750. Epub 2022 Dec 20. Aging Cell. 2023. PMID: 36539941 Free PMC article.
Antiretroviral drugs have dramatically improved the prognosis of HIV-infected patients, with strikingly reduced morbidity and mortality. However, long-term use can be associated with signs of premature aging. Highly active antiretroviral therapy generally comprises two nuc …
Antiretroviral drugs have dramatically improved the prognosis of HIV-infected patients, with strikingly reduced morbidity and mortality. How …
Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.
Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J. Demaria M, et al. Cancer Discov. 2017 Feb;7(2):165-176. doi: 10.1158/2159-8290.CD-16-0241. Epub 2016 Dec 15. Cancer Discov. 2017. PMID: 27979832 Free PMC article.
Using a transgenic mouse that permits tracking and eliminating senescent cells, we show that therapy-induced senescent (TIS) cells persist and contribute to local and systemic inflammation. Eliminating TIS cells reduced several short- and long-term effects of the drugs, in …
Using a transgenic mouse that permits tracking and eliminating senescent cells, we show that therapy-induced senescent (TIS) cells persist a …
ATM suppresses SATB1-induced malignant progression in breast epithelial cells.
Ordinario E, Han HJ, Furuta S, Heiser LM, Jakkula LR, Rodier F, Spellman PT, Campisi J, Gray JW, Bissell MJ, Kohwi Y, Kohwi-Shigematsu T. Ordinario E, et al. PLoS One. 2012;7(12):e51786. doi: 10.1371/journal.pone.0051786. Epub 2012 Dec 10. PLoS One. 2012. PMID: 23251624 Free PMC article.
We found the reason for reduction to be phenotypic drift due to long-term cultivation of MCF10A. ATM knockdown in MCF10A-2 and two other non-malignant breast epithelial cell lines, 184A1 and 184B4, enabled SATB1 to induce malignant phenotypes similar to that observed for M …
We found the reason for reduction to be phenotypic drift due to long-term cultivation of MCF10A. ATM knockdown in MCF10A-2 and two ot …
GROα regulates human embryonic stem cell self-renewal or adoption of a neuronal fate.
Krtolica A, Larocque N, Genbacev O, Ilic D, Coppe JP, Patil CK, Zdravkovic T, McMaster M, Campisi J, Fisher SJ. Krtolica A, et al. Differentiation. 2011 Apr;81(4):222-32. doi: 10.1016/j.diff.2011.01.001. Epub 2011 Mar 10. Differentiation. 2011. PMID: 21396766 Free PMC article.
Previously we reported that feeders formed from human placental fibroblasts (hPFs) support derivation and long-term self-renewal of human embryonic stem cells (hESCs) under serum-free conditions. ...These data support our hypothesis that establishing and maintaining cell p …
Previously we reported that feeders formed from human placental fibroblasts (hPFs) support derivation and long-term self-renewal of h …
DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion.
Rodier F, Muñoz DP, Teachenor R, Chu V, Le O, Bhaumik D, Coppé JP, Campeau E, Beauséjour CM, Kim SH, Davalos AR, Campisi J. Rodier F, et al. J Cell Sci. 2011 Jan 1;124(Pt 1):68-81. doi: 10.1242/jcs.071340. Epub 2010 Nov 30. J Cell Sci. 2011. PMID: 21118958 Free PMC article.
To understand how persistent damage foci differ from transient foci that mark repairable DNA lesions, we identify sequential events that differentiate transient foci from persistent foci, which we term 'DNA segments with chromatin alterations reinforcing senescence' (DNA-S …
To understand how persistent damage foci differ from transient foci that mark repairable DNA lesions, we identify sequential events that dif …
p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cells.
Bazarov AV, Van Sluis M, Hines WC, Bassett E, Beliveau A, Campeau E, Mukhopadhyay R, Lee WJ, Melodyev S, Zaslavsky Y, Lee L, Rodier F, Chicas A, Lowe SW, Benhattar J, Ren B, Campisi J, Yaswen P. Bazarov AV, et al. Aging Cell. 2010 Oct;9(5):736-46. doi: 10.1111/j.1474-9726.2010.00599.x. Epub 2010 Jul 14. Aging Cell. 2010. PMID: 20569236 Free PMC article.
We show that transient expression of p16 stably represses the hTERT gene, encoding the catalytic subunit of telomerase, in both normal and malignant breast epithelial cells. Short-term p16 expression increases the amount of histone H3 trimethylated on lysine 27 (H3K27) bou …
We show that transient expression of p16 stably represses the hTERT gene, encoding the catalytic subunit of telomerase, in both normal and m …
Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status.
Le ON, Rodier F, Fontaine F, Coppe JP, Campisi J, DeGregori J, Laverdière C, Kokta V, Haddad E, Beauséjour CM. Le ON, et al. Aging Cell. 2010 Jun;9(3):398-409. doi: 10.1111/j.1474-9726.2010.00567.x. Epub 2010 Mar 13. Aging Cell. 2010. PMID: 20331441 Free PMC article.
We hypothesized that IR-induced senescence markers could persist long-term in vivo, possibly contributing to the permanent reduction in tissue functionality. ...Together, our results provide compelling evidence that exposure to IR induces long-term expression of sen …
We hypothesized that IR-induced senescence markers could persist long-term in vivo, possibly contributing to the permanent reduction …