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Systemic propranolol acts centrally to reduce conditioned fear in rats without impairing extinction.
Rodriguez-Romaguera J, Sotres-Bayon F, Mueller D, Quirk GJ. Rodriguez-Romaguera J, et al. Biol Psychiatry. 2009 May 15;65(10):887-92. doi: 10.1016/j.biopsych.2009.01.009. Epub 2009 Feb 26. Biol Psychiatry. 2009. PMID: 19246030 Free PMC article.
Reduced fear with intact extinction suggests a possible use for propranolol in reducing anxiety during extinction-based exposure therapies, without interfering with long-term clinical response....
Reduced fear with intact extinction suggests a possible use for propranolol in reducing anxiety during extinction-based exposure therapies, …
Memory for extinction of conditioned fear is long-lasting and persists following spontaneous recovery.
Quirk GJ. Quirk GJ. Learn Mem. 2002 Nov-Dec;9(6):402-7. doi: 10.1101/lm.49602. Learn Mem. 2002. PMID: 12464700 Free PMC article.
These data support the idea that conditioning and extinction of fear are learned by independent systems, each able to retain a long-term memory....
These data support the idea that conditioning and extinction of fear are learned by independent systems, each able to retain a long-term …
Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory.
Santini E, Muller RU, Quirk GJ. Santini E, et al. J Neurosci. 2001 Nov 15;21(22):9009-17. doi: 10.1523/JNEUROSCI.21-22-09009.2001. J Neurosci. 2001. PMID: 11698611 Free PMC article.
This suggests that an NMDA-independent form of plasticity supports short-term extinction memory, but NMDA receptors are required for consolidation processes leading to long-term extinction memory. ...
This suggests that an NMDA-independent form of plasticity supports short-term extinction memory, but NMDA receptors are required for …