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Retrieving fear memories, as time goes by….
Do Monte FH, Quirk GJ, Li B, Penzo MA. Do Monte FH, et al. Mol Psychiatry. 2016 Aug;21(8):1027-36. doi: 10.1038/mp.2016.78. Epub 2016 May 24. Mol Psychiatry. 2016. PMID: 27217148 Free PMC article. Review.
A temporal shift in the circuits mediating retrieval of fear memory.
Do-Monte FH, Quiñones-Laracuente K, Quirk GJ. Do-Monte FH, et al. Nature. 2015 Mar 26;519(7544):460-3. doi: 10.1038/nature14030. Epub 2015 Jan 19. Nature. 2015. PMID: 25600268 Free PMC article.
Thus, the PVT may act as a crucial thalamic node recruited into cortico-amygdalar networks for retrieval and maintenance of long-term fear memories....
Thus, the PVT may act as a crucial thalamic node recruited into cortico-amygdalar networks for retrieval and maintenance of long-term …
Systemic propranolol acts centrally to reduce conditioned fear in rats without impairing extinction.
Rodriguez-Romaguera J, Sotres-Bayon F, Mueller D, Quirk GJ. Rodriguez-Romaguera J, et al. Biol Psychiatry. 2009 May 15;65(10):887-92. doi: 10.1016/j.biopsych.2009.01.009. Epub 2009 Feb 26. Biol Psychiatry. 2009. PMID: 19246030 Free PMC article.
Reduced fear with intact extinction suggests a possible use for propranolol in reducing anxiety during extinction-based exposure therapies, without interfering with long-term clinical response....
Reduced fear with intact extinction suggests a possible use for propranolol in reducing anxiety during extinction-based exposure therapies, …
Lesions of the basal amygdala block expression of conditioned fear but not extinction.
Anglada-Figueroa D, Quirk GJ. Anglada-Figueroa D, et al. J Neurosci. 2005 Oct 19;25(42):9680-5. doi: 10.1523/JNEUROSCI.2600-05.2005. J Neurosci. 2005. PMID: 16237172 Free PMC article.
Replicating previous studies, we found that rats given electrolytic BA lesions before training acquired conditioned fear normally. They also showed normal long-term retention and extinction of conditioned fear. Unexpectedly, BA lesions made after training completely blocke …
Replicating previous studies, we found that rats given electrolytic BA lesions before training acquired conditioned fear normally. They also …
Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex.
Santini E, Ge H, Ren K, Peña de Ortiz S, Quirk GJ. Santini E, et al. J Neurosci. 2004 Jun 23;24(25):5704-10. doi: 10.1523/JNEUROSCI.0786-04.2004. J Neurosci. 2004. PMID: 15215292 Free PMC article.
Extinction of conditioned fear is thought to form a long-term memory of safety, but the neural mechanisms are poorly understood. ...
Extinction of conditioned fear is thought to form a long-term memory of safety, but the neural mechanisms are poorly understood. ...