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Retrieving fear memories, as time goes by….
Mol Psychiatry. 2016 Aug;21(8):1027-36. doi: 10.1038/mp.2016.78. Epub 2016 May 24.
Mol Psychiatry. 2016.
PMID: 27217148
Free PMC article.
Review.
A temporal shift in the circuits mediating retrieval of fear memory.
Do-Monte FH, Quiñones-Laracuente K, Quirk GJ.
Do-Monte FH, et al.
Nature. 2015 Mar 26;519(7544):460-3. doi: 10.1038/nature14030. Epub 2015 Jan 19.
Nature. 2015.
PMID: 25600268
Free PMC article.
Thus, the PVT may act as a crucial thalamic node recruited into cortico-amygdalar networks for retrieval and maintenance of long-term fear memories....
Thus, the PVT may act as a crucial thalamic node recruited into cortico-amygdalar networks for retrieval and maintenance of long-term …
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Systemic propranolol acts centrally to reduce conditioned fear in rats without impairing extinction.
Rodriguez-Romaguera J, Sotres-Bayon F, Mueller D, Quirk GJ.
Rodriguez-Romaguera J, et al.
Biol Psychiatry. 2009 May 15;65(10):887-92. doi: 10.1016/j.biopsych.2009.01.009. Epub 2009 Feb 26.
Biol Psychiatry. 2009.
PMID: 19246030
Free PMC article.
Reduced fear with intact extinction suggests a possible use for propranolol in reducing anxiety during extinction-based exposure therapies, without interfering with long-term clinical response....
Reduced fear with intact extinction suggests a possible use for propranolol in reducing anxiety during extinction-based exposure therapies, …
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Lesions of the basal amygdala block expression of conditioned fear but not extinction.
Anglada-Figueroa D, Quirk GJ.
Anglada-Figueroa D, et al.
J Neurosci. 2005 Oct 19;25(42):9680-5. doi: 10.1523/JNEUROSCI.2600-05.2005.
J Neurosci. 2005.
PMID: 16237172
Free PMC article.
Replicating previous studies, we found that rats given electrolytic BA lesions before training acquired conditioned fear normally. They also showed normal long-term retention and extinction of conditioned fear. Unexpectedly, BA lesions made after training completely blocke …
Replicating previous studies, we found that rats given electrolytic BA lesions before training acquired conditioned fear normally. They also …
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Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex.
Santini E, Ge H, Ren K, Peña de Ortiz S, Quirk GJ.
Santini E, et al.
J Neurosci. 2004 Jun 23;24(25):5704-10. doi: 10.1523/JNEUROSCI.0786-04.2004.
J Neurosci. 2004.
PMID: 15215292
Free PMC article.
Extinction of conditioned fear is thought to form a long-term memory of safety, but the neural mechanisms are poorly understood. ...
Extinction of conditioned fear is thought to form a long-term memory of safety, but the neural mechanisms are poorly understood. ...
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