Transcriptional firing represses bactericidal activity in cystic fibrosis airway neutrophils.
Cell Rep Med. 2021 Apr 8;2(4):100239. doi: 10.1016/j.xcrm.2021.100239. eCollection 2021 Apr 20.
Cell Rep Med. 2021.
PMID: 33948572
Free PMC article.
Treatment by the RNA polymerase II and III inhibitor alpha-amanitin restores the expression of key antimicrobial genes and increases the bactericidal capacity of CF airway neutrophils in vitro and in short-term sputum cultures ex vivo. Broadly, our findings show that neutr …
Treatment by the RNA polymerase II and III inhibitor alpha-amanitin restores the expression of key antimicrobial genes and increases the bac …