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2011 3
2012 2
2021 1
2024 0

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A therapeutic convection-enhanced macroencapsulation device for enhancing β cell viability and insulin secretion.
Yang K, O'Cearbhaill ED, Liu SS, Zhou A, Chitnis GD, Hamilos AE, Xu J, Verma MKS, Giraldo JA, Kudo Y, Lee EA, Lee Y, Pop R, Langer R, Melton DA, Greiner DL, Karp JM. Yang K, et al. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2101258118. doi: 10.1073/pnas.2101258118. Proc Natl Acad Sci U S A. 2021. PMID: 34504013 Free PMC article.
Finally, to address potential translational barriers, we outlined future steps necessary to optimize the ceMED design for long-term efficacy and clinical utility....
Finally, to address potential translational barriers, we outlined future steps necessary to optimize the ceMED design for long-term e …
A portable chemotaxis platform for short and long term analysis.
Xu C, Poh YK, Roes I, O'Cearbhaill ED, Matthiesen ME, Mu L, Yang SY, Miranda-Nieves D, Irimia D, Karp JM. Xu C, et al. PLoS One. 2012;7(9):e44995. doi: 10.1371/journal.pone.0044995. Epub 2012 Sep 17. PLoS One. 2012. PMID: 23028729 Free PMC article.
Specifically, we developed a standalone chemotaxis platform that has the same footprint as a multiwell plate and can generate well-defined, stable chemical gradients continuously for up to 7 days. Using this platform, we validated the short-term (24 hours) and long-term …
Specifically, we developed a standalone chemotaxis platform that has the same footprint as a multiwell plate and can generate well-defined, …
Tracking mesenchymal stem cells with iron oxide nanoparticle loaded poly(lactide-co-glycolide) microparticles.
Xu C, Miranda-Nieves D, Ankrum JA, Matthiesen ME, Phillips JA, Roes I, Wojtkiewicz GR, Juneja V, Kultima JR, Zhao W, Vemula PK, Lin CP, Nahrendorf M, Karp JM. Xu C, et al. Nano Lett. 2012 Aug 8;12(8):4131-9. doi: 10.1021/nl301658q. Epub 2012 Jul 12. Nano Lett. 2012. PMID: 22769232 Free PMC article.
Monitoring the location, distribution and long-term engraftment of administered cells is critical for demonstrating the success of a cell therapy. ...
Monitoring the location, distribution and long-term engraftment of administered cells is critical for demonstrating the success of a …
Nanoparticle-based monitoring of cell therapy.
Xu C, Mu L, Roes I, Miranda-Nieves D, Nahrendorf M, Ankrum JA, Zhao W, Karp JM. Xu C, et al. Nanotechnology. 2011 Dec 9;22(49):494001. doi: 10.1088/0957-4484/22/49/494001. Epub 2011 Nov 21. Nanotechnology. 2011. PMID: 22101191 Free PMC article. Review.
To develop effective cell therapy, the location, distribution and long-term persistence of transplanted cells must be evaluated. Nanoparticle (NP) based imaging technologies have the potential to track transplanted cells non-invasively. ...
To develop effective cell therapy, the location, distribution and long-term persistence of transplanted cells must be evaluated. Nano …
Sensing the cardiac environment: exploiting cues for regeneration.
Pereira MJ, Carvalho IF, Karp JM, Ferreira LS. Pereira MJ, et al. J Cardiovasc Transl Res. 2011 Oct;4(5):616-30. doi: 10.1007/s12265-011-9299-6. Epub 2011 Jul 7. J Cardiovasc Transl Res. 2011. PMID: 21735303 Free PMC article. Review.
Regarding stem cells, a growing body of data suggests that the short-term positive outcomes are mainly attributed to paracrine signaling mechanisms. ...To overcome this, the long-term controlled delivery of bioactive factors using biomaterials is a promising approac …
Regarding stem cells, a growing body of data suggests that the short-term positive outcomes are mainly attributed to paracrine signal …
Immobilized contrast-enhanced MRI: Gadolinium-based long-term MR contrast enhancement of the vein graft vessel wall.
Mitsouras D, Vemula PK, Yu P, Tao M, Nguyen BT, Campagna CM, Karp JM, Mulkern RV, Ozaki CK, Rybicki FJ. Mitsouras D, et al. Magn Reson Med. 2011 Jan;65(1):176-83. doi: 10.1002/mrm.22606. Magn Reson Med. 2011. PMID: 20859994 Free PMC article.
This efficiency can be realized as either increased contrast leading to more accurate delineation of vessel wall and lesion tissue boundaries, or, faster imaging without penalizing contrast-to-noise ratio, or a combination thereof. We demonstrate, for the first time, stable long- …
This efficiency can be realized as either increased contrast leading to more accurate delineation of vessel wall and lesion tissue boundarie …