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2011 | 1 |
2016 | 1 |
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The connexin 43 carboxyl terminal mimetic peptide αCT1 prompts differentiation of a collagen scar matrix in humans resembling unwounded skin.
FASEB J. 2021 Aug;35(8):e21762. doi: 10.1096/fj.202001881R.
FASEB J. 2021.
PMID: 34246197
Free PMC article.
Clinical Trial.
In conclusion, alphaCT1 prompts decreased directionality of fibroblast movement and the generation of a 3D collagen matrix postwounding that is similar to unwounded skin-changes that correlate with long-term improvement in scar appearance....
In conclusion, alphaCT1 prompts decreased directionality of fibroblast movement and the generation of a 3D collagen matrix postwounding that …
Can heart function lost to disease be regenerated by therapeutic targeting of cardiac scar tissue?
Ongstad EL, Gourdie RG.
Ongstad EL, et al.
Semin Cell Dev Biol. 2016 Oct;58:41-54. doi: 10.1016/j.semcdb.2016.05.020. Epub 2016 May 24.
Semin Cell Dev Biol. 2016.
PMID: 27234380
Free PMC article.
Review.
The intensive research focus on regeneration of myocardial tissues has, as of yet, only met with modest success, with no near-term prospect of improving standard-of-care for patients with heart disease. ...
The intensive research focus on regeneration of myocardial tissues has, as of yet, only met with modest success, with no near-term pr …
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Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1.
Rhett JM, Jourdan J, Gourdie RG.
Rhett JM, et al.
Mol Biol Cell. 2011 May;22(9):1516-28. doi: 10.1091/mbc.E10-06-0548. Epub 2011 Mar 16.
Mol Biol Cell. 2011.
PMID: 21411628
Free PMC article.
Immunoprecipitation and Duolink protein-protein interaction assays indicated that inhibition targets ZO-1 binding with Cx43 in GJs as well as connexons in an adjacent domain that we term the "perinexus." Consistent with GJ size increases being matched by decreases in conne …
Immunoprecipitation and Duolink protein-protein interaction assays indicated that inhibition targets ZO-1 binding with Cx43 in GJs as well a …
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