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The connexin 43 carboxyl terminal mimetic peptide αCT1 prompts differentiation of a collagen scar matrix in humans resembling unwounded skin.
Montgomery J, Richardson WJ, Marsh S, Rhett JM, Bustos F, Degen K, Ghatnekar GS, Grek CL, Jourdan LJ, Holmes JW, Gourdie RG. Montgomery J, et al. FASEB J. 2021 Aug;35(8):e21762. doi: 10.1096/fj.202001881R. FASEB J. 2021. PMID: 34246197 Free PMC article. Clinical Trial.
In conclusion, alphaCT1 prompts decreased directionality of fibroblast movement and the generation of a 3D collagen matrix postwounding that is similar to unwounded skin-changes that correlate with long-term improvement in scar appearance....
In conclusion, alphaCT1 prompts decreased directionality of fibroblast movement and the generation of a 3D collagen matrix postwounding that …
Can heart function lost to disease be regenerated by therapeutic targeting of cardiac scar tissue?
Ongstad EL, Gourdie RG. Ongstad EL, et al. Semin Cell Dev Biol. 2016 Oct;58:41-54. doi: 10.1016/j.semcdb.2016.05.020. Epub 2016 May 24. Semin Cell Dev Biol. 2016. PMID: 27234380 Free PMC article. Review.
The intensive research focus on regeneration of myocardial tissues has, as of yet, only met with modest success, with no near-term prospect of improving standard-of-care for patients with heart disease. ...
The intensive research focus on regeneration of myocardial tissues has, as of yet, only met with modest success, with no near-term pr …
Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1.
Rhett JM, Jourdan J, Gourdie RG. Rhett JM, et al. Mol Biol Cell. 2011 May;22(9):1516-28. doi: 10.1091/mbc.E10-06-0548. Epub 2011 Mar 16. Mol Biol Cell. 2011. PMID: 21411628 Free PMC article.
Immunoprecipitation and Duolink protein-protein interaction assays indicated that inhibition targets ZO-1 binding with Cx43 in GJs as well as connexons in an adjacent domain that we term the "perinexus." Consistent with GJ size increases being matched by decreases in conne …
Immunoprecipitation and Duolink protein-protein interaction assays indicated that inhibition targets ZO-1 binding with Cx43 in GJs as well a …