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Sex-specific effects of in vitro fertilization on adult metabolic outcomes and hepatic transcriptome and proteome in mouse.
Narapareddy L, Rhon-Calderon EA, Vrooman LA, Baeza J, Nguyen DK, Mesaros C, Lan Y, Garcia BA, Schultz RM, Bartolomei MS. Narapareddy L, et al. FASEB J. 2021 Apr;35(4):e21523. doi: 10.1096/fj.202002744R. FASEB J. 2021. PMID: 33734487 Free PMC article.
Although in vitro fertilization (IVF) is associated with adverse perinatal outcomes, there is increasing concern about the long-term and sex-specific health implications. Augmenting our IVF mouse model to longitudinally investigate metabolic outcomes in offspring from opti …
Although in vitro fertilization (IVF) is associated with adverse perinatal outcomes, there is increasing concern about the long-term …
Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability.
Nelson DM, Jaber-Hijazi F, Cole JJ, Robertson NA, Pawlikowski JS, Norris KT, Criscione SW, Pchelintsev NA, Piscitello D, Stong N, Rai TS, McBryan T, Otte GL, Nixon C, Clark W, Riethman H, Wu H, Schotta G, Garcia BA, Neretti N, Baird DM, Berger SL, Adams PD. Nelson DM, et al. Genome Biol. 2016 Jul 25;17(1):158. doi: 10.1186/s13059-016-1017-x. Genome Biol. 2016. PMID: 27457071 Free PMC article.
Rather, we speculate that H4K20me3 plays a role in heterochromatinization and stabilization of the epigenome and genome of pre-malignant, oncogene-expressing senescent cells, thereby suppressing epigenetic and genetic instability and contributing to long-term senescence-me …
Rather, we speculate that H4K20me3 plays a role in heterochromatinization and stabilization of the epigenome and genome of pre-malignant, on …
Monitoring Cellular Phosphorylation Signaling Pathways into Chromatin and Down to the Gene Level.
Han Y, Yuan ZF, Molden RC, Garcia BA. Han Y, et al. Mol Cell Proteomics. 2016 Mar;15(3):834-53. doi: 10.1074/mcp.M115.053421. Epub 2015 Nov 5. Mol Cell Proteomics. 2016. PMID: 26543102 Free PMC article.
Here, we describe the optimization and comparison of methods based on thiophosphorylation affinity enrichment, which can be utilized to monitor phosphorylation signaling into chromatin by isolation of phosphoprotein containing nucleosomes, a method we term phosphorylation- …
Here, we describe the optimization and comparison of methods based on thiophosphorylation affinity enrichment, which can be utilized to moni …