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2013 1
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Page 1
High Frequency of Neuroimaging Abnormalities Among Pediatric Patients With Sepsis Who Undergo Neuroimaging.
Sandquist MK, Clee MS, Patel SK, Howard KA, Yunger T, Nagaraj UD, Jones BV, Fei L, Vadivelu S, Wong HR. Sandquist MK, et al. Pediatr Crit Care Med. 2017 Jul;18(7):607-613. doi: 10.1097/PCC.0000000000001173. Pediatr Crit Care Med. 2017. PMID: 28498230 Free PMC article.
CONCLUSIONS: The majority of pediatric patients with sepsis and concurrent or subsequent neuroimaging have abnormal neuroimaging findings. The implications of this high incidence for long-term neurologic outcomes and follow-up require further exploration....
CONCLUSIONS: The majority of pediatric patients with sepsis and concurrent or subsequent neuroimaging have abnormal neuroimaging findings. T …
Primary Outcome Measures in Pediatric Septic Shock Trials: A Systematic Review.
Menon K, McNally JD, Zimmerman JJ, Agus MS, O'Hearn K, Watson RS, Wong HR, Duffett M, Wypij D, Choong K. Menon K, et al. Pediatr Crit Care Med. 2017 Mar;18(3):e146-e154. doi: 10.1097/PCC.0000000000001078. Pediatr Crit Care Med. 2017. PMID: 28099233 Free PMC article. Review.
CONCLUSIONS: Our review found that use of mortality alone as a primary outcome in pediatric septic shock trials was associated with significant limitations and that long-term patient-centered outcomes were not used in this setting. Composite outcomes incorporating mortalit …
CONCLUSIONS: Our review found that use of mortality alone as a primary outcome in pediatric septic shock trials was associated with signific …
Time for a neonatal-specific consensus definition for sepsis.
Wynn JL, Wong HR, Shanley TP, Bizzarro MJ, Saiman L, Polin RA. Wynn JL, et al. Pediatr Crit Care Med. 2014 Jul;15(6):523-8. doi: 10.1097/PCC.0000000000000157. Pediatr Crit Care Med. 2014. PMID: 24751791 Free PMC article. Review.
OBJECTIVE: To review the accuracy of the pediatric consensus definition of sepsis in term neonates and to determine the definition of neonatal sepsis used. ...Thus, specific consensus definitions for both term and preterm neonates are needed. Such definitions are cr …
OBJECTIVE: To review the accuracy of the pediatric consensus definition of sepsis in term neonates and to determine the definition of …
Combined zinc supplementation with proinsulin C-peptide treatment decreases the inflammatory response and mortality in murine polymicrobial sepsis.
Slinko S, Piraino G, Hake PW, Ledford JR, O'Connor M, Lahni P, Solan PD, Wong HR, Zingarelli B. Slinko S, et al. Shock. 2014 Apr;41(4):292-300. doi: 10.1097/SHK.0000000000000127. Shock. 2014. PMID: 24430544 Free PMC article.
These beneficial effects were associated with restored lung nuclear expression of PPARgamma and reduction of phosphorylated extracellular signal-regulated kinases 1 and 2 and nuclear factor kappaB activities in comparison to vehicle or single treatment protocols. Our data demonst …
These beneficial effects were associated with restored lung nuclear expression of PPARgamma and reduction of phosphorylated extracellular si …
Pediatric sepsis: challenges and adjunctive therapies.
Hanna W, Wong HR. Hanna W, et al. Crit Care Clin. 2013 Apr;29(2):203-22. doi: 10.1016/j.ccc.2012.11.003. Epub 2013 Jan 3. Crit Care Clin. 2013. PMID: 23537672 Free PMC article. Review.
This review provides an appraisal of adjunctive therapies for sepsis and highlights opportunities for meeting selected challenges in the field. Future clinical studies should address long-term and functional outcomes as well as acute outcomes. Potential adjunctive therapie …
This review provides an appraisal of adjunctive therapies for sepsis and highlights opportunities for meeting selected challenges in the fie …